Data Sheet 1_Global trends in esophageal cancer: sex and age disparities in health inequalities from 1990 to 2021, with projections to 2050.pdf by Ying Liu (18461)

“…</p>Conclusion<p>Although projections indicate a decreasing trend, health inequalities have intensified. …”

Table 6_Global trends in esophageal cancer: sex and age disparities in health inequalities from 1990 to 2021, with projections to 2050.docx by Ying Liu (18461)

“…</p>Conclusion<p>Although projections indicate a decreasing trend, health inequalities have intensified. …”

Table 1_Integrated physiological and transcriptomic analyses elucidate the molecular mechanisms of exogenous melatonin-mediated salt tolerance in pomegranate (Punica granatum L.).x... by Yuanling Yang (22524785)

“…In contrast, 400 μM MT treatment effectively mitigated oxidative damage by coordinated activation of superoxide dismutase (SOD,+14.3%), peroxidase (POD,+21.7%), and catalase (CAT,+11.7%) activities, thereby stabilizing membrane integrity. Furthermore, MT significantly alleviated photoinhibition: F_V/F_M increased by 39%, Y_II and qP rose, and NPQ decreased compared to salt-stressed plants, reflecting enhanced protection of the PSII reaction center and optimized light energy allocation. …”

Yeast strains used in this study. by Hilary T. Brewis (11798006)

“…Furthermore, as H2A.Z mutants only display significant growth defects in genotoxic stress conditions, a more substantive role for H2A.Z in gene expression may only be uncovered after exposure to cellular stress. …”

Association between the difference in estimated GFR based on cystatin C versus creatinine in coronary artery diseases by Zechen Liu (9200014)

“…When eGFR_diff was treated as a continuous variable, a statistically significant trend toward a lower risk of CAD as eGFR_diff increased (HR 0.982, 95% CI 0.981-0.982). …”

Image1_Characterization of GABAergic marker expression in prefrontal cortex in dexamethasone induced depression/anxiety model.jpeg by Ling Hu (374570)

“…Furthermore, DEX treatment reduced the expression levels of a GABA-synthesizing enzyme (GAD67), Reelin, calcium-binding proteins (parvalbumin and calretinin) and neuropeptides co-expressed in GABAergic neurons (somatostatin, neuropeptide Y and vasoactive intestinal peptide) in the PFC were reduced after 21 days of DEX treatment; these reductions were accompanied by decreases in brain size and cerebral cortex thickness.…”

Data Sheet 1_Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System Xc−/GPX4 pathway.csv by Jiejie Hu (6190622)

“…Protein–protein interaction (PPI) analysis combined with molecular complex detection (MCODE) identified six hub genes, namely, Ddit3, Atf3, Sesn2, Trib3, Ppp1r15a, and Gadd45a. Spearman’s correlation analysis revealed a significant correlation between the hub genes and ferroptosis-related DEGs. …”

Table1_GLYCINE betaine and seaweed-based biostimulants improved leaf water status and enhanced photosynthetic activity in sweet cherry trees.docx by Sílvia Afonso (20456483)

“…Biostimulants, especially EM, demonstrated a significant positive effect (p ≤ 0.001) on total phenolic content, with increases of approximately 25% to 50% in treated leaves. …”

Data Sheet 1_Global impact of Occupational Noise-Induced Hearing Loss (ONIHL): trends, gender disparities, and future projections: 1990–2036.docx by Dandan Liu (303719)

“…In 2021, the YLDs rate decreased as the Socio-Demographic Index (SDI) increased across 224 countries, indicating a concentration of the burden in countries with a medium SDI. …”

Supplementary Figure S2 from Targeting AXL Inhibits the Growth and Metastasis of Prostate Cancer in Bone by Chun-Lung Chiu (20972235)

“…Human PCa cells marked by Ku70 were significantly decreased after 30 days of treatment by intraperitoneal injection with batiraxcept (20 mg/kg/QOD, n = 8–9, docetaxel (10 mg/kg/QW, n = 9) or the combination of batiraxcept (20 mg/kg/QOD, n = 9) and docetaxel (10 mg/kg/QW, n = 9) compared to vehicle controls (n = 8,10). …”

Supplementary Material for: Exosomal TIMP4 from myocardial cell relieves heart failure by influencing Th17/Treg Balance by figshare admin karger (2628495)

“…Results: Analysis of the GSE196656 dataset revealed significant upregulation of TIMP4 in heart failure. …”

DataSheet2_Screening of active components of melastoma dodecandrum lour. against diabetic osteoporosis using cell membrane chromatography-mass spectrometry.pdf by Xiaoqin Zhang (517854)

“…Cell experiments further validated the activity of the characteristic component isovitexin.</p>Results<p>MD significantly improved cell viability in AGEs-damaged osteoblasts, enhanced ALP, SOD, CAT, and GPx activities, reduced MDA levels, increased OCN and RUNX2 protein expression, and decreased TNF-α mRNA and RAGE protein expression. …”

Table2_Predicting candidate miRNAs for targeting begomovirus to induce sequence-specific gene silencing in chilli plants.xlsx by Vineeta Pandey (10043698)

“…Chilli cultivars infected with begomovirus have suffered significant decreases in biomass output, negatively impacting their economic characteristics. …”

Image 3_IL-33 signaling is dispensable for the IL-10-induced enhancement of mast cell responses during food allergy.jpeg by Dylan Krajewski (5881880)

“…IL-10-depleted WT mice exhibited a significant attenuation in MC-mediated responses to OVA challenge. …”

Divergent gene expression in <i>D. sechellia.</i> by Daehan Lee (5043377)

“…<p><b>(A)</b> Histogram of the frequency of <i>D. sechellia</i>-specific DEGs across 94 cell types, arranged by decreasing DEG number. …”

Table_3_Functional Characterization of Olfactory Proteins Involved in Chemoreception of Galeruca daurica.DOCX by Ling Li (38566)

“…The EAG response of G. daurica females to 2-hexenal was significantly decreased in dsRNA-OBP15-injected treatment compared to the control, and the dsRNA-CSP5-treated females significantly reduced EAG response to eight tested host volatiles (1,3-dithiane, 2-hexenal, methyl benzoate, dimethyl trisulfide, myrcene, hexanal, 1,3,5-cycloheptatriene, and p-xylene). …”

Supplementary file 1_Disproportionality analysis of taste disorders using the FDA adverse event reporting system and Japanese adverse drug event report databases.docx by Yoji Kyotani (599686)

“…The hazard for clarithromycin remained constant throughout administration, while the hazards for the other drugs decreased over time. Logistic regression analysis confirmed significant associations between the drugs and taste disorders, even after adjusting for age and sex. …”

Image8_Integrating anoikis and ErbB signaling insights with machine learning and single-cell analysis for predicting prognosis and immune-targeted therapy outcomes in hepatocellula... by Huipeng Fang (12587509)

“…Background<p>Hepatocellular carcinoma (HCC) poses a significant global health challenge due to its poor prognosis and limited therapeutic modalities. …”

Table 1_Inner engineering is associated with perceived improvements in relationship quality, interpersonal connections, and interpersonal compassion.docx by Nashaw Jafari (20467640)

“…Linear mixed-effects models were used to analyze the survey data, with p-values of < 0.05 considered statistically significant.</p>Results<p>From the baseline to the 6-week follow-up after the program, the participants reported experiencing more positive qualities (p < 0.001, ηp2 = 0.12) and fewer negative qualities (p = 0.001, ηp2 = 0.08) in their relationships, increased interpersonal mindfulness (p < 0.001, ηp2 = 0.30), decreased stress levels (p < 0.001, ηp2 = 0.27), enhanced compassion for others (p < 0.001, ηp2 = 0.17), and overall personal wellbeing (p < 0.001, ηp2 = 0.25).…”

Image9_Integrating anoikis and ErbB signaling insights with machine learning and single-cell analysis for predicting prognosis and immune-targeted therapy outcomes in hepatocellula... by Huipeng Fang (12587509)

“…Background<p>Hepatocellular carcinoma (HCC) poses a significant global health challenge due to its poor prognosis and limited therapeutic modalities. …”