Image 2_L1, a 3,3′-diindolylmethane-derivative, induced ER stress-mediated apoptosis and suppressed growth through the FLI1/AKT pathway in erythroleukemia HEL cells.tif حسب Yi Kuang (1873354)

"…Moreover, FLI1 is a crucial target for mediating cell differentiation, apoptosis, inflammation and displays abnormal expression in HEL cells. Here, we showed that the protein expression levels of FLI1 and AKT/p-AKT decreased with L1 treatment and that the RNA expressions of their downstream genes GATA1, TFRC, GYPA, CDKN1A and CDKN1B were also regulated by L1.…"

Table 8_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.xlsx حسب Xiaofeng Li (342614)

"…Pharmacogenomic analysis identified vinblastine with differential sensitivity, providing actionable targets for RS-stratified therapy.</p>Conclusion<p>We elucidated the significant impact of crotonylation on the ovarian cancer microenvironment and prognosis. …"

Table 9_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.xlsx حسب Xiaofeng Li (342614)

"…Pharmacogenomic analysis identified vinblastine with differential sensitivity, providing actionable targets for RS-stratified therapy.</p>Conclusion<p>We elucidated the significant impact of crotonylation on the ovarian cancer microenvironment and prognosis. …"

Table 7_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.csv حسب Xiaofeng Li (342614)

"…Pharmacogenomic analysis identified vinblastine with differential sensitivity, providing actionable targets for RS-stratified therapy.</p>Conclusion<p>We elucidated the significant impact of crotonylation on the ovarian cancer microenvironment and prognosis. …"

Table 3_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.csv حسب Xiaofeng Li (342614)

"…Pharmacogenomic analysis identified vinblastine with differential sensitivity, providing actionable targets for RS-stratified therapy.</p>Conclusion<p>We elucidated the significant impact of crotonylation on the ovarian cancer microenvironment and prognosis. …"

Image 1_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.jpeg حسب Xiaofeng Li (342614)

"…Pharmacogenomic analysis identified vinblastine with differential sensitivity, providing actionable targets for RS-stratified therapy.</p>Conclusion<p>We elucidated the significant impact of crotonylation on the ovarian cancer microenvironment and prognosis. …"

Image 2_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.tif حسب Xiaofeng Li (342614)

"…Pharmacogenomic analysis identified vinblastine with differential sensitivity, providing actionable targets for RS-stratified therapy.</p>Conclusion<p>We elucidated the significant impact of crotonylation on the ovarian cancer microenvironment and prognosis. …"

Table 2_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.csv حسب Xiaofeng Li (342614)

"…Pharmacogenomic analysis identified vinblastine with differential sensitivity, providing actionable targets for RS-stratified therapy.</p>Conclusion<p>We elucidated the significant impact of crotonylation on the ovarian cancer microenvironment and prognosis. …"

Image 3_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.tif حسب Xiaofeng Li (342614)

"…Pharmacogenomic analysis identified vinblastine with differential sensitivity, providing actionable targets for RS-stratified therapy.</p>Conclusion<p>We elucidated the significant impact of crotonylation on the ovarian cancer microenvironment and prognosis. …"

Table 5_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.csv حسب Xiaofeng Li (342614)

"…Pharmacogenomic analysis identified vinblastine with differential sensitivity, providing actionable targets for RS-stratified therapy.</p>Conclusion<p>We elucidated the significant impact of crotonylation on the ovarian cancer microenvironment and prognosis. …"

Table 4_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.xlsx حسب Xiaofeng Li (342614)

"…Pharmacogenomic analysis identified vinblastine with differential sensitivity, providing actionable targets for RS-stratified therapy.</p>Conclusion<p>We elucidated the significant impact of crotonylation on the ovarian cancer microenvironment and prognosis. …"

Image 4_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.tif حسب Xiaofeng Li (342614)

"…Pharmacogenomic analysis identified vinblastine with differential sensitivity, providing actionable targets for RS-stratified therapy.</p>Conclusion<p>We elucidated the significant impact of crotonylation on the ovarian cancer microenvironment and prognosis. …"

Table 6_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.csv حسب Xiaofeng Li (342614)

"…Pharmacogenomic analysis identified vinblastine with differential sensitivity, providing actionable targets for RS-stratified therapy.</p>Conclusion<p>We elucidated the significant impact of crotonylation on the ovarian cancer microenvironment and prognosis. …"

Table 1_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.xlsx حسب Xiaofeng Li (342614)

"…Pharmacogenomic analysis identified vinblastine with differential sensitivity, providing actionable targets for RS-stratified therapy.</p>Conclusion<p>We elucidated the significant impact of crotonylation on the ovarian cancer microenvironment and prognosis. …"

Data Sheet 1_Reduced circulating regulatory T cells in primary Sjögren’s syndrome: the contribution of enhanced apoptosis and impaired survival.docx حسب Yanlin Wang (110566)

"…We identified 187 upregulated and 674 downregulated DEGs in sorted Tregs from pSS patients, including five apoptotic pathway hub genes (XIAP, CASP3, CASP10, NFKBIA, and PMAIP1)-a finding consistent with increased Treg apoptosis in pSS. …"

Low temperature reduces byssus adhesion of highly invasive golden mussels: Influencing mechanisms and antifouling implications حسب Miaolian Zhang (21974951)

"…Finally, it includes integrated DEG and DEM data from co-enrichment pathway analyses, revealing coordinated biological pathways significantly altered under low-temperature conditions. …"

Data Sheet 1_Effects of Th1/Th17 and Th2 cytokines on lipid metabolism in differentiated keratinocytes.zip حسب Alessia Cavallo (13036581)

"…Th1/ Th17 downregulated the ELOVL3 gene, which is implicated in the FAs elongation, while the mRNA levels of ABCA12 and HMGCR, genes involved in lipids transport and cholesterol synthesis, respectively, were decreased with both cytokine mixtures. DEGS1 and DEGS2, key enzymes in the ceramide synthesis, were downregulated and upregulated in the Th1/Th17 and Th2 environments, respectively. …"

Data Sheet 1_Integrated transcriptome and co-expression network analysis revealed the molecular mechanism of cold tolerance in japonica rice at booting stage.zip حسب Jiaqi Wang (369548)

"…</p>Results<p>The results demonstrated that cold stress significantly decreased yield traits, particularly seed-setting rate—a reliable cold tolerance indicator. …"

Image 1_A four-gene signature identified by integrated transcriptomic analysis for differential diagnosis and prognosis of uterine smooth muscle tumors.pdf حسب Huiyi Hu (11226995)

"…</p>Methods<p>We analyzed RNA-seq datasets from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) using GEO2R, Limma, and Weighted Gene Co-expression Network Analysis (WGCNA) to identify differentially expressed genes (DEGs) in ULMS and ULM. …"

Supplementary file 1_Transcriptome-wide N6-methyladenosinem modifications analysis of chicken cecum in responding to Campylobacter jejuni inoculation.zip حسب Yanan Zhao (3132906)

"…</p>Results<p>In the S group, the level of proinflammatory cytokines (IL-8, IL-1β, IL-18, TNF-α, IL-17A) and global RNA methylation were significantly decreased (P < 0.05). A total of 30,427 and 30,367 m⁶A peaks were identified in R and S groups, which were primarily located in 3'UTR and CDS regions. …"