Engineering and Functional Expression of the Type III Secretion System in <i>Xenorhabdus</i>: Enhancing Insecticidal Efficacy and Expanding T3SE Libraries by Xiyin Huang (11528200)

“…In <i>Helicoverpa armigera</i> models, the engineered strain induced severe intestinal damage by suppressing antimicrobial peptide expression and demonstrated improved colonization and biocontrol efficacy (LC₅₀ decreased by 3.7-fold). Crucially, the TT01 derived T3SS mediated delivery of XopAa novel effector exhibiting YopJ-family homology and characteristic T3SS effector featuresinto host cells. …”

Engineering and Functional Expression of the Type III Secretion System in <i>Xenorhabdus</i>: Enhancing Insecticidal Efficacy and Expanding T3SE Libraries by Xiyin Huang (11528200)

“…In <i>Helicoverpa armigera</i> models, the engineered strain induced severe intestinal damage by suppressing antimicrobial peptide expression and demonstrated improved colonization and biocontrol efficacy (LC₅₀ decreased by 3.7-fold). Crucially, the TT01 derived T3SS mediated delivery of XopAa novel effector exhibiting YopJ-family homology and characteristic T3SS effector featuresinto host cells. …”

Engineering and Functional Expression of the Type III Secretion System in <i>Xenorhabdus</i>: Enhancing Insecticidal Efficacy and Expanding T3SE Libraries by Xiyin Huang (11528200)

“…In <i>Helicoverpa armigera</i> models, the engineered strain induced severe intestinal damage by suppressing antimicrobial peptide expression and demonstrated improved colonization and biocontrol efficacy (LC₅₀ decreased by 3.7-fold). Crucially, the TT01 derived T3SS mediated delivery of XopAa novel effector exhibiting YopJ-family homology and characteristic T3SS effector featuresinto host cells. …”

Engineering and Functional Expression of the Type III Secretion System in <i>Xenorhabdus</i>: Enhancing Insecticidal Efficacy and Expanding T3SE Libraries by Xiyin Huang (11528200)

“…In <i>Helicoverpa armigera</i> models, the engineered strain induced severe intestinal damage by suppressing antimicrobial peptide expression and demonstrated improved colonization and biocontrol efficacy (LC₅₀ decreased by 3.7-fold). Crucially, the TT01 derived T3SS mediated delivery of XopAa novel effector exhibiting YopJ-family homology and characteristic T3SS effector featuresinto host cells. …”

Engineering and Functional Expression of the Type III Secretion System in <i>Xenorhabdus</i>: Enhancing Insecticidal Efficacy and Expanding T3SE Libraries by Xiyin Huang (11528200)

“…In <i>Helicoverpa armigera</i> models, the engineered strain induced severe intestinal damage by suppressing antimicrobial peptide expression and demonstrated improved colonization and biocontrol efficacy (LC₅₀ decreased by 3.7-fold). Crucially, the TT01 derived T3SS mediated delivery of XopAa novel effector exhibiting YopJ-family homology and characteristic T3SS effector featuresinto host cells. …”

IFN-responsive and anti-viral pathways are induced in γδ T cells post-HIV-1 acquisition. by Gina L. Griffith (20649097)

Structure of the OHC model. by Yihan Liao (13807348)

Osteogenic Potential and Long-Term Enzymatic Biodegradation of PHB-based Scaffolds with Composite Magnetic Nanofillers in a Magnetic Field by Lada E. Shlapakova (13200592)

“…Six-month biodegradation caused a reduction in surface potential (1.5-fold) and in a vertical piezoresponse (3.5-fold) of the Fe₃O₄–GO scaffold because of a decrease in the PHB β-phase content. …”

Untargeted Urinary Proteomics Uncovers Nephroprotective and Systemic Adaptations after Obesity Surgery-Induced Weight Loss by Pedro R. Pereira (6016460)

“…Among the 2347 identified proteins, 1016 depicted a significantly different abundance postsurgery (<i>p</i> < 0.05). …”

Tissue-specific expression of splice variants diversifying the LR2 region of Calcineurin A/TAX-6 in <i>C. elegans.</i> by Martina Rudgalvyte (22320301)

Cascade Nanozyme-Loaded Sprayable Hydrogels for Fibroblast Rejuvenation and Diabetic Wound Regeneration by Xinyi Zhang (36040)

“…Under oxidative and hyperglycemic culture conditions, we validated the zcg mechanism of blocking the AGEs-ROS cycle, restoring fibroblast mitochondrial membrane potential, and subsequently suppressing cellular senescence. In a bacterial-infected diabetic rat skin wound model, the zcgG group demonstrated substantially reduced inflammatory levels, a 68% decrease in AGEs, and a 1.9-fold increase in collagen deposition compared to blank controls. …”

Alteration of Ubiquitination in the Brain of ENOPH1 Knockout Mice after Early Ischemic Stroke by Yike Wu (20982007)

“…Hence, the present study explored changes in the ubiquitinomic in early ischemic brain tissues between wildtype and ENOPH1 knockout mice using a comprehensive quantitative analysis. Our results showed that 4000 ubiquitination-modified sites in 1613 proteins were quantified, with 772 ubiquitinated sites in 464 proteins significantly decreasing or increasing after ENOPH1 knockout (fold change >1.5 or <1/1.5, <i>p</i> < 0.05). …”

Alteration of Ubiquitination in the Brain of ENOPH1 Knockout Mice after Early Ischemic Stroke by Yike Wu (20982007)

“…Hence, the present study explored changes in the ubiquitinomic in early ischemic brain tissues between wildtype and ENOPH1 knockout mice using a comprehensive quantitative analysis. Our results showed that 4000 ubiquitination-modified sites in 1613 proteins were quantified, with 772 ubiquitinated sites in 464 proteins significantly decreasing or increasing after ENOPH1 knockout (fold change >1.5 or <1/1.5, <i>p</i> < 0.05). …”

Volcano plot showing the results of the RESP contrast for the peripheral blood mononuclear cell (PBMC) samples at 34 days post-infection (dpi). by Gillian P. McHugo (8965919)

“…<p>Each data point represents a gene with the position on the <i><i>x</i></i>- and <i><i>y</i></i>-axes indicating the log₂ fold change and -log₁₀<i><i>P</i></i><sub>adj.…”

Forest plots comparing demographic factors within SARS-CoV-2 variant waves. by Rebecca M. Cantu (19787070)

Effect of overexpressing <i>CEBPB</i> and <i>GFI-1</i> on <i>SOST</i> expression. by Avneesh Chopra (20927514)

“…Increased LAP2 expression correlated with weakly reduced <i>SOST</i> expression (1.89-fold reduction, P <  0.01), and an increase in LIP expression showed a very slightly decreased <i>SOST</i> expression level (1.2-fold reduction, P <  0.05) (<b>right panel</b>). …”

Short-Ranged United-Atom Model for Efficient Simulations of Glycerol and Its Aqueous Mixtures by Prabir Khatua (1738339)

“…When combined with mW water, SR-UA glycerol successfully reproduces key features of glycerol–water mixtures, including the decrease in the temperature of maximum density and the dynamical crossover, in agreement with AA simulations across a range of temperatures and concentrations. …”

Related to Fig 2. by Mohammad Nafees Ansari (22232505)

“…(<b>E</b>) Altered glucosylceramide/ceramide ratio reveals a decrease in glucosylceramides in BT-474_RICTOR^SH cells compared to BT-474 cells. …”

RICTOR silencing inhibits cell proliferation via UGCG regulation. by Mohammad Nafees Ansari (22232505)

“…(<b>E</b>) Heat map representing normalized absolute quantitation of ceramides and glucosylceramides in MCF-7_RICTOR^SH and MCF-7 cells. (<b>F</b>) Fold change (mean ± SEM, <i>n</i> = 5) in different sphingolipid species reveals an increase in ceramides and a decrease in glucosylceramides in MCF-7_RICTOR^SH cells compared to MCF-7 cells. …”

Related to Fig 1. by Mohammad Nafees Ansari (22232505)

“…(<b>E</b>–<b>H</b>) Absolute quantification (mean ± SEM, <i>n</i> = 3–4) of GM3 (E), GD3 (F), GM2 (G), and GM1 (H) gangliosides shows an increase in GD3 and GM2 gangliosides and a decrease in GM3 and GM1 gangliosides in BT-474_UGCG^OE cells compared to BT-474 cells. …”