Effects of T5-1 and T5-12 on TAS2R5 expression during protein synthesis inhibition. by Donghwa Kim (252081)

RICTOR regulates UGCG expression via transcription factor Zinc Finger X-linked (ZFX). by Mohammad Nafees Ansari (22232505)

“…<b>(J, K)</b> Immunoblots (J) and their quantification (mean ± SEM, <i>n</i> = 3) (K) show upregulation and downregulation of UGCG upon overexpression and silencing of ZFX in MCF-7_ZFX^OE and MCF-7_ZFX^SL cells. <b>(L, M)</b> Fold change (mean ± SEM, <i>n</i> = 5) in ceramides (L) and glucosylceramides (M) confirms a decrease in ceramides and an increase in glucosylceramides in MCF-7_ZFX^OE cells. …”

Ydj1 acetylation alters interactions with client proteins. by Siddhi Omkar (12413434)

“…Interactors are colored according to change in interaction as follows: green (significant increase), red (significant decrease), or purple (no significant change) 6KQ/6KR. …”

Ydj1 acetylation impacts multiple aspects of translation. by Siddhi Omkar (12413434)

Table 1_Fibromyalgia diagnosis from a multi-omics approach: a gut feeling.pdf by Elena Durán-González (17438448)

“…After the raw data analysis, proteins with statistically significant differential abundance and a fold change over 1.2 (20% increase in fibromyalgia compared with control samples) or under 0.8 (20% decrease in fibromyalgia compared with control samples) in fibromyalgia were selected. …”

C2CD3 regulates spatial organization of centriole architecture. by Eloïse Bertiaux (5309927)

C2CD3 is crucial for the localization of the LDR and DISCO complexes. by Eloïse Bertiaux (5309927)

Predicted chronic activation of the cardiomyocyte signaling network during VO. by Johane H. Bracamonte (12883844)

Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α₁‑Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents by Chaoquan Tian (21009122)

“…The potency of compound <b>10</b> against ANO1 was comparable to that of <b>Tam</b> (IC₅₀: 4.57 vs 7.22 μM), but its selectivity over α₁-AR was significantly improved. Compared with <b>Tam</b>, the potency of compound <b>10</b> against α_1A-, α_1B-, and α_1D-AR decreased by 118-fold, 642-fold, and 10,000-fold, respectively. …”

Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α₁‑Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents by Chaoquan Tian (21009122)

“…The potency of compound <b>10</b> against ANO1 was comparable to that of <b>Tam</b> (IC₅₀: 4.57 vs 7.22 μM), but its selectivity over α₁-AR was significantly improved. Compared with <b>Tam</b>, the potency of compound <b>10</b> against α_1A-, α_1B-, and α_1D-AR decreased by 118-fold, 642-fold, and 10,000-fold, respectively. …”

Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α₁‑Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents by Chaoquan Tian (21009122)

“…The potency of compound <b>10</b> against ANO1 was comparable to that of <b>Tam</b> (IC₅₀: 4.57 vs 7.22 μM), but its selectivity over α₁-AR was significantly improved. Compared with <b>Tam</b>, the potency of compound <b>10</b> against α_1A-, α_1B-, and α_1D-AR decreased by 118-fold, 642-fold, and 10,000-fold, respectively. …”

Differences in pTSS profiles between pre- and full-term pregnancies. by Zhiwei Guo (335819)

MDSC inhibition was correlated with Trp metabolism in 17ZR101-infected lungs. by Qi Xu (134661)

“…Fold change > 1.2 and FDR-adjusted P-value < 0.05 considered significant. …”

Primer pairs for RT-qPCR. by Yoichi Kurokawa (22290520)

“…Conversely, exposure to endogenous prooxidants (dopamine and adrenaline), certain food-derived polyphenols (chrysin and 3-<i><i>O</i></i>-methylquercetin), or 1,2-naphthoquinone led to a significant decrease (<0.5-fold) in Rmst expression. …”

RT-qPCR data tables. by Yoichi Kurokawa (22290520)

“…Conversely, exposure to endogenous prooxidants (dopamine and adrenaline), certain food-derived polyphenols (chrysin and 3-<i><i>O</i></i>-methylquercetin), or 1,2-naphthoquinone led to a significant decrease (<0.5-fold) in Rmst expression. …”

Minimal data set. by Zhaoping Meng (4875040)

“…Twenty-two differential metabolites (VIP ≥ 1) were identified using untargeted metabolomics. 3 primary metabolites, namely mannose, pyruvate, and shikimic acid, together with 2 secondary metabolites, phenylalanine and mevalonic acid, were observed to decrease. 17 secondary metabolites, including Schisandrin A, Schisandrin B, Schisandrin C, Gomisin D, Gomisin G, Gomisin H, Benzoylgomisin H, Benzoylgomisin O,Angeloylgomisin P, Catechin, Isorhamnetin, Luteolin, Cinnamic acid, Hydroxycinnamic acid, Hexahydrocurcumin, Coniferyl alcohol, Phenylalanine, Terpinolene and Mevalonic acid, exhibited increases in their levels by 10.64, 1.84, 1.40, 1.64, 4.46, 8.18, 1.72, 10.20, 2.08, 1.27, 1.57, 1.18, 2.01, 1.12, 1.88, 1.15, and 3.17-fold, respectively. …”

Changes in volume, mass, and end-diastolic strain during experimental MR in dogs. by Johane H. Bracamonte (12883844)

Validation of model predictions of growth during infusion of hypertrophic agonists with and without receptor blockers. by Johane H. Bracamonte (12883844)

“…By contrast, the model prediction of nearly equal likelihood that ERA increases or decreases NE-induced growth appears to contradict a significant reported decrease in the only available experimental study [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref121" target="_blank">121</a>]. …”

Key biological processes and genes are identified in TGF-β1-induced fibrosis via transcriptome analysis. by Dong-Hee Han (140305)

“…<p>After treatment with 1 and 5 ng/mL TGF-β1 for 48 h, mRNA transcriptome analysis was performed. <b>(A)</b> Differentially expressed genes (DEGs; ≥2 folds, ≥7 normalized data value) significantly altered by TGF-β1 treatment were depicted by a Venn diagram. …”

Care quality. by Youssef Hbid (18803761)

“…Stroke multidisciplinary access increased during the first lockdown but decreased in subsequent periods. Access to thrombectomy sequentially increased across time periods; by 40% during first lockdown (adjusted Odd-Ratio: 1.4; 95% CI:1.24–1.58), second lockdown (aOR: 1.77; 1.66–1.92), and 2-folds post-lockdown (aOR: 2.03; 1.92–2.15). …”