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Cyclization Decoded: Engineering Amylomaltase for Efficient α‑Glucan Transformations
Published 2025“…Enzyme kinetics results suggest that the improvement in enzyme performance largely stems from the decrease in enzyme–substrate affinity along the substrate transfer pathway. …”
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Patients outcome.
Published 2025“…Reliance on temporal-artery biopsy fell (17% vs 91%; p < 0.01), owing to a four-fold rise in diagnostic MRI use. Mean total medical costs decreased by €814 per patient (€3672 ± 2861 vs €4486 ± 3193), although this difference did not reach statistical significance (p = 0.23).…”
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Minimal data set.
Published 2025“…Twenty-two differential metabolites (VIP ≥ 1) were identified using untargeted metabolomics. 3 primary metabolites, namely mannose, pyruvate, and shikimic acid, together with 2 secondary metabolites, phenylalanine and mevalonic acid, were observed to decrease. 17 secondary metabolites, including Schisandrin A, Schisandrin B, Schisandrin C, Gomisin D, Gomisin G, Gomisin H, Benzoylgomisin H, Benzoylgomisin O,Angeloylgomisin P, Catechin, Isorhamnetin, Luteolin, Cinnamic acid, Hydroxycinnamic acid, Hexahydrocurcumin, Coniferyl alcohol, Phenylalanine, Terpinolene and Mevalonic acid, exhibited increases in their levels by 10.64, 1.84, 1.40, 1.64, 4.46, 8.18, 1.72, 10.20, 2.08, 1.27, 1.57, 1.18, 2.01, 1.12, 1.88, 1.15, and 3.17-fold, respectively. …”
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Fragmentation patterns for Schisandrin A.
Published 2025“…Twenty-two differential metabolites (VIP ≥ 1) were identified using untargeted metabolomics. 3 primary metabolites, namely mannose, pyruvate, and shikimic acid, together with 2 secondary metabolites, phenylalanine and mevalonic acid, were observed to decrease. 17 secondary metabolites, including Schisandrin A, Schisandrin B, Schisandrin C, Gomisin D, Gomisin G, Gomisin H, Benzoylgomisin H, Benzoylgomisin O,Angeloylgomisin P, Catechin, Isorhamnetin, Luteolin, Cinnamic acid, Hydroxycinnamic acid, Hexahydrocurcumin, Coniferyl alcohol, Phenylalanine, Terpinolene and Mevalonic acid, exhibited increases in their levels by 10.64, 1.84, 1.40, 1.64, 4.46, 8.18, 1.72, 10.20, 2.08, 1.27, 1.57, 1.18, 2.01, 1.12, 1.88, 1.15, and 3.17-fold, respectively. …”
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Chemical structure of a lignan.
Published 2025“…Twenty-two differential metabolites (VIP ≥ 1) were identified using untargeted metabolomics. 3 primary metabolites, namely mannose, pyruvate, and shikimic acid, together with 2 secondary metabolites, phenylalanine and mevalonic acid, were observed to decrease. 17 secondary metabolites, including Schisandrin A, Schisandrin B, Schisandrin C, Gomisin D, Gomisin G, Gomisin H, Benzoylgomisin H, Benzoylgomisin O,Angeloylgomisin P, Catechin, Isorhamnetin, Luteolin, Cinnamic acid, Hydroxycinnamic acid, Hexahydrocurcumin, Coniferyl alcohol, Phenylalanine, Terpinolene and Mevalonic acid, exhibited increases in their levels by 10.64, 1.84, 1.40, 1.64, 4.46, 8.18, 1.72, 10.20, 2.08, 1.27, 1.57, 1.18, 2.01, 1.12, 1.88, 1.15, and 3.17-fold, respectively. …”
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Development of a User-Friendly Dynamic Culture System for Decellularized Scaffold-Based Tissue Engineering
Published 2025“…Compared to static controls, constructs cultured in our platform exhibited a > 5-fold increase in proliferating (Ki67+) cells and a 32-fold decrease in apoptotic (TUNEL+) cells. …”
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Table 1_Dynamic decline in estimated glomerular filtration rate associated with in-hospital mortality risk in acute ischemic stroke patients after endovascular therapy: evidence fr...
Published 2025“…Patients who died exhibited a progressive decline in eGFR (P < 0.05), while survivors showed a modest increase (P < 0.01). After comprehensive adjustment for confounders, each 1 mL/min/1.73 m<sup>2</sup> decrease in day-3 eGFR was associated with a 3% increase in mortality risk (P < 0.001); moderate-to-severe renal dysfunction (eGFR < 60 mL/min/1.73 m<sup>2</sup>) on day 3 was associated with a 4.3-fold increased risk of death (P < 0.001). …”
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Supplementary file 1_Drug utilization study of antiparkinsonian medication in Romania during 25 years.pdf
Published 2025“…</p>Results<p>The utilization of antiparkinsonian medication increased considerably (6-folds) in Romania during the 25 years, from 1.03 DDD/TID in 1998 to 6.22 DDD/TID in 2022. …”
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Table 1_Examining the mediating function of SIRI in the association between LC9 and chronic obstructive pulmonary disease.docx
Published 2025“…When multiple covariates were taken into account, logistic regression analysis showed that a 28% decrease in the prevalence of COPD was linked to every 10-point increase in LC9 (OR = 0.72, 95% CI: 0.67, 0.77), while a 1.17-fold increase in the prevalence of COPD was linked to each unit increase in SIRI (OR = 1.17, 95% CI: 1.10, 1.25). …”
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Table 1_Comparative study of endophytic bacterial strains from non-host crops for enhancing plant growth and managing early blight in tomato.docx
Published 2024“…Field trials confirmed the glasshouse findings, showing reduced early blight and improved growth parameters in tomato where the ST + SD + FS combination emerged as the most effective treatment for all endophytes showing 1.06–1.88 fold increase in fruit yield per plant and 28.92–32.52% decrease in PDI compared to untreated control. …”
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DataSheet1_RETRACTED: Ophthalmic Combination of SurR9-C84A and Trichostatin-A Targeting Molecular Pathogenesis of Alkali Burn.DOCX
Published 2025“…An insult with 0.5 N NaOH for 1 min led to neutrophils infiltration and formation of large vacuoles in the stroma. Treatments with TSA and SurR9-C84A for 40 min led to improvement in the conjunctival and corneal tissue integrity, marked by an increase in clathrin, and claudin expressions. …”
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Supplementary Tables S1 and S2
Published 2025“…However, both plasma-free and plasma-containing buffer induced small but significant increases in secretion of several cytokines over the sample collection period. …”
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COMPOSITIONS AND METHODS FOR TREATMENT OF NEUROLOGICAL DISEASE
Published 2024“…In some preferred embodiments, these have been designed using dehydroascorbic acid, ascorbic acid and amino acids as carriers that result in a significant increase in brain MMF concentration and mitochondrial biogenesis activity. …”
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Data Sheet 1_Anchoring from shipping as a disturbance agent to temperate rocky reef fish: marked shifts observed in trophic and taxonomic guilds.pdf
Published 2025“…Abundance measures were largely driven by the shoaling zooplanktivore; Atypichthys strigatus, with near four-fold increases of this trophic group on anchored reefs. …”