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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
gene increased » center increased (Expand Search), rate increased (Expand Search), use increased (Expand Search)
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20361
Table 1_Mirodenafil improves cognitive function by reducing microglial activation and blood–brain barrier permeability in ApoE4 KI mice.pdf
Published 2025“…Introduction<p>Alzheimer’s disease (AD) has significant public health concerns in the aging society. …”
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20362
Image 3_OCNDS core features are conserved across variants, with loop-region mutations driving greater symptom burden.jpg
Published 2025“…Introduction<p>Okur-Chung Neurodevelopmental Syndrome (OCNDS) is an ultra-rare genetic disorder caused by de novo mutations in the CSNK2A1 gene, which encodes the catalytic subunit of protein kinase CK2α. …”
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20363
Supplementary file 1_OCNDS core features are conserved across variants, with loop-region mutations driving greater symptom burden.docx
Published 2025“…Introduction<p>Okur-Chung Neurodevelopmental Syndrome (OCNDS) is an ultra-rare genetic disorder caused by de novo mutations in the CSNK2A1 gene, which encodes the catalytic subunit of protein kinase CK2α. …”
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20364
Data Sheet 1_Water-sediment regulation drives stage-specific microbial shifts and network complexity in the Yellow River reservoir-river continuum.docx
Published 2025“…<p>High-turbidity rivers, exemplified by the Yellow River, face significant ecological risks due to anthropogenic water-sediment regulation (WSR), which disrupts sedimentary habitats and biogeochemical cycles. …”
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20365
Table 1_Predicting immune-related adverse events in patients with melanoma: the role of interleukin-7 rs16906115 polymorphism and lymphocyte dynamics.docx
Published 2025“…Subgroup analyses revealed a significant increase in risk across endocrine, non-cutaneous, multiple, low-grade, and early onset (<3 months) irAEs. …”
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20366
Image 2_Breaking the heterogeneity barrier: a robust prognostic signature for survival stratification and immune profiling in triple-negative breast cancer.jpeg
Published 2025“…Therapeutic vulnerability profiling identified six targeted agents showing increased efficacy in high-risk patients. Dysregulation of signature genes was demonstrated in two TNBC cell lines.…”
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20367
Image1_Human adipose mesenchymal stem cell-derived exosomes alleviate fibrosis by restraining ferroptosis in keloids.TIF
Published 2025“…ADSC-Exos effectively suppressed keloid fibrosis progression and increased GSH and GPX4 gene expression. Additionally, the use of Erastin limits the effect of ADSC-Exos in keloids. …”
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20368
Image 1_A prognostic framework integrating endoplasmic reticulum stress dynamics reveals clinical stratification and differential prognostic attributes in osteosarcoma patients.tif
Published 2025“…We developed a robust ER stress model comprising ten ER stress-associated genes specifically tailored for osteosarcoma patients. …”
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20369
Data Sheet 1_Identifying fecal microbiota signatures of colorectal cancer in a Vietnamese cohort.pdf
Published 2024“…The total community DNA of microorganisms was extracted from the fecal samples and analyzed for microbiota composition using Illumina MiSeq amplicon sequencing targeting the V3–V4 region of the 16S rRNA gene.</p>Results<p>We identified a significant difference in the overall fecal microbiota composition between CRC patients and healthy controls, and we detected several CRC-associated microbial signatures in fecal samples of Vietnamese patients with CRC, which overlapped with signatures from other countries and meta-analyses. …”
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20370
Table 1_Dual benefits of Bacillus velezensis LJ-19: contact-dependent biocontrol of Fusarium wilt and growth promotion in cucumber.docx
Published 2025“…Pot experiments demonstrated that LJ-19 treatment significant increased the stem thickness, fresh weight, leaf area, and overall biomass in cucumber. …”
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20371
Table 1_A novel vasculogenic mimicry-related nomogram predicts prognosis in hepatocellular carcinoma.docx
Published 2025“…The predictive significance of the related gene signature was confirmed in the GSE14520 cohort. …”
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20372
Data Sheet 1_Complement and coagulation cascade cross-talk in endometriosis and the potential of Janus Kinase inhibitors—a network meta-analysis.xlsx
Published 2025“…</p>Results<p>EEM compared to EH upregulated CCL21 and downregulated BIRC3, CEL, and LEFTY1 genes (|log<sub>2</sub>FC| > 0.5, p < 0.05). EL showed increased expression of complement and serpin genes (EL vs. …”
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20373
Table 1_Bioinformatics analysis reveals novel tumor antigens and immune subtypes of skin cutaneous melanoma contributing to mRNA vaccine development.xlsx
Published 2025“…</p>Results<p>We discovered five tumor antigens (P2RY6, PLA2G2D, RBM47, SEL1L3, and SPIB) that are significantly increased and mutated, which correlate with the survival of patients and the presence of immune cells that present these antigens. …”
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20374
Data Sheet 1_Bioinformatics analysis reveals novel tumor antigens and immune subtypes of skin cutaneous melanoma contributing to mRNA vaccine development.docx
Published 2025“…</p>Results<p>We discovered five tumor antigens (P2RY6, PLA2G2D, RBM47, SEL1L3, and SPIB) that are significantly increased and mutated, which correlate with the survival of patients and the presence of immune cells that present these antigens. …”
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20375
Image 2_A novel vasculogenic mimicry-related nomogram predicts prognosis in hepatocellular carcinoma.tif
Published 2025“…The predictive significance of the related gene signature was confirmed in the GSE14520 cohort. …”
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20376
Table 2_Bioinformatics analysis reveals novel tumor antigens and immune subtypes of skin cutaneous melanoma contributing to mRNA vaccine development.xlsx
Published 2025“…</p>Results<p>We discovered five tumor antigens (P2RY6, PLA2G2D, RBM47, SEL1L3, and SPIB) that are significantly increased and mutated, which correlate with the survival of patients and the presence of immune cells that present these antigens. …”
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20377
Table 1_Complement and coagulation cascade cross-talk in endometriosis and the potential of Janus Kinase inhibitors—a network meta-analysis.docx
Published 2025“…</p>Results<p>EEM compared to EH upregulated CCL21 and downregulated BIRC3, CEL, and LEFTY1 genes (|log<sub>2</sub>FC| > 0.5, p < 0.05). EL showed increased expression of complement and serpin genes (EL vs. …”
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20378
An IS element-driven antisense RNA attenuates the expression of serotype 2 fimbriae and the cytotoxicity of <i>Bordetella pertussis</i>
Published 2025“…Interestingly, the mutant that does not produce Rfi2 displayed significantly increased cytotoxicity towards human macrophages compared to the parental strain. …”
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20379
Image 1_A novel vasculogenic mimicry-related nomogram predicts prognosis in hepatocellular carcinoma.tif
Published 2025“…The predictive significance of the related gene signature was confirmed in the GSE14520 cohort. …”
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20380
Data Sheet 1_Establishment of human periodontal ligament cell lines with ALPL mutations to mimic dental aspects of hypophosphatasia.pdf
Published 2025“…Introduction<p>Besides skeletal symptoms, dental abnormalities are a typical feature of the rare inherited disorder hypophosphatasia (HPP), which is caused by loss of function mutations in the ALPL gene (alkaline phosphatase, biomineralization associated) coding for tissue-nonspecific alkaline phosphatase (TNAP). …”