Supplementary Material for: Preliminary efficacy, tolerability, and safety analysis of Darolutamide for metastatic castration‑resistant prostate cancer: a single-center, open-label... by Yu J. (3610580)

“…The median time to PSA50 in the Darolutamide group was 1.5 months (95%CI 0.2619- 0.9545), significantly lower than that in the placebo group (3.0 months [95%CI 1.048- 3.818], p= 0.0259); The median time to PSA90 in the experimental group was 4 months (95%CI 0.3094- 1.437), 2 months shorter than that in the placebo group (6.0 months [95%CI 0.6961- 3.232]).With the median follow-up of 6 months, , the median decrease in serum PSA was -81.8% (range -60.4 to -99.9%) in the Darolutamide group and -69.4% (range -50.3 to -89.6%) in the placebo group. …”

<b>Efficacy of </b><b>GLP-1-based Therapies on</b><b> </b><b>Metabolic Dysfunction-Associated Steatotic</b><b> Liver Disease and </b><b>Metabolic Dysfunction-Associated</b><b> Stea... by Yahao Wang (21291242)

“…GLP-1RAs treatment significantly decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) andγ-glutamyl transferase (GGT) compared with control. …”

<b>Contrasting strategies, shared risk: 12-yr nitrogen addition compromises hydraulic safety in young and mature trees via distinct pathways</b> by Shijie Ning (17757825)

“…However, this apparent adaptive response was accompanied by a significant increase in xylem vulnerability to embolism as reflected by the stimulated percentage loss of hydraulic conductivity, indicating a potential trade-off between greater root carbon investment and hydraulic safety. …”

Data from: Decade-long bird trends in China: Stable species richness but increasing biotic homogenization by Jiekun He (20964269)

“…Taxonomic multiple-site beta diversity decreased over time (P < 0.01), indicating a trend towards biotic homogenization. …”

Data Sheet 2_Red mite (Panonychus citri) attack amplifies citrus rootstock-driven responses in physiological and biochemical traits, VOC emission, and expression of defence-related... by Tommy Rioja (22179742)

“…‘Macrophylla’ exhibited limited changes, whereas ‘C35’ displayed high MDA content and PITY1 induction, suggesting greater oxidative stress. Photosynthetic pigments declined across all combinations after infestation, while soluble sugars and flavonoids decreased in susceptible rootstocks. …”

Antioxidants gene expressions in two tissues suspected to be involved in Decompression Sickness (DCS) triggering, in DCS resistant rats_Data by Emmanuel Dugrenot (18447504)

“…At the opposite, in the liver, we observed a decreased expression in both group of genes (except for <i>Pgc1α</i>), related to a selection effect.…”

<b>Impact of Magnitude and Duration of Soil Warming on Bacterial Communities and Nitrogen Cycling in the Rhizosphere and Bulk Soil of Subarctic Grasslands</b> by Arun Kumar Devarajan (21358373)

“…The results revealed that bacterial abundances showed significant warming thresholds at lower temperature increases in the rhizospheres (+0.83℃ in GN, +1.34℃ in GO) compared to bulk soils (+1.42℃ in GN; no threshold detected in GO), with abundances declining below these thresholds, indicating greater warming sensitivity of rhizosphere communities. …”

Table1_Assessment of the potential for carbon sink enhancement in the overlapping ecological project areas of China.docx by Xiaojuan Xu (765611)

“…In contrast, the carbon sinks did not significantly increase in regions with two or three ecological projects. (2) As the number of ecological projects increased, the impact of human activities on the carbon sinks gradually decreased. …”

Supplementary Material for: Light exposure on alertness after wake-up in healthy men: Comparing dim, bright, red and blue light by Mekschrat L. (19669585)

“…However, dim vs. bright light and RT did not interact (p = .758). Chronotype was a significant covariate in the interaction of dim vs. bright light and subjective sleepiness (p = .008). …”

Data Sheet 1_Red mite (Panonychus citri) attack amplifies citrus rootstock-driven responses in physiological and biochemical traits, VOC emission, and expression of defence-related... by Tommy Rioja (22179742)

“…‘Macrophylla’ exhibited limited changes, whereas ‘C35’ displayed high MDA content and PITY1 induction, suggesting greater oxidative stress. Photosynthetic pigments declined across all combinations after infestation, while soluble sugars and flavonoids decreased in susceptible rootstocks. …”

Data Sheet 1_Prevalence of kidney stones based on metabolic health and weight criteria: reports from the national health and nutrition examination survey 2007-2018 data analysis.pd... by Xijie Ding (21583937)

“…After full adjustment, compared to participants with MHN, the MHO and MUO groups exhibited significantly greater risks of kidney stones (MHO: OR = 2.10, 95% CI:1.47–2.98, P < 0.001; MUO: OR = 1.98, 95% CI:1.45–2.67, P < 0.001). …”

Table 1_Sex disparities in the risk of intracranial aneurysm rupture: a case–control study.docx by Dong Shen (485693)

“…In the subgroups based on the covariates used in this study, we only identified statistically significant interaction between sex and age. Although ruptured IAs were most common in males and females aged 50–59 and 60–69 years, respectively, risk of IA rupture peaked at ages 30 and 30–50 years in females and males, respectively, and decreased with age in both sexes.…”

Table 1_Intergenerational education mobility in India: nonlinearity and the Great Gatsby Curve.docx by P. K. V. Kishan (19744606)

“…</p>Results<p>Our analysis reveals a high degree of intergenerational persistence in education, although this persistence has decreased over time. Employing quantile regressions, we observe significant nonlinearities in the relationship between fathers’ and sons’ educational outcomes across the educational distribution. …”

Data Sheet 1_Citywide community-based colorectal cancer screening in urban Shanghai: age and sex variations in risk mitigation from 1973 to 2020.docx by Mengyin Wu (8778272)

“…However, elderly mortality decreased significantly (APC: 1.47% to −3.03%, P < 0.001).…”

Table 2_Global, regional and national patterns and gender disparity of intraocular foreign bodies from 1990 to 2021.doc by Yi Shan (160293)

“…</p>Results<p>The total all-age prevalence and DALYs due to IOFBs rose by 41.9 and 35.5%, respectively, from 1990 to 2021, and the age-standardized prevalence and DALYs rates decreased by 15.2 and 19.6%. The IOFBs burden was greater among middle-aged and older adult men, especially in 45–49 years. …”

Growth and physiological response of Yulu <i>Hippophae rhamnoides</i> to drought stress and its omics analysis by Haipeng Chen (7228403)

“…In T1 and T2, the differential genes were significantly enriched in the plant hormone signal transduction pathway, but there was no significant enrichment in the protein expression profile. …”

Table 1_Physical and chemical characteristics of pyrogenic carbon from peatland vegetation fires differ across burn severities.xlsx by Oscar J. Kennedy-Blundell (20506349)

“…O/C and H/C ratios decreased with increasing severity. FTIR showed that distinct spectra were produced between severity groups, reflecting increased sample aromaticity with burn severity.…”

Data Sheet 1_Probiotic administration correlated with reduced diarrheal incidence and improved gut microbiota diversity in young goats.pdf by Mohamed Osman Abdalrahem Essa (21562583)

“…</p>Results<p>Healthy groups exhibited significantly greater species richness and diversity compared to the diarrheal group (p < 0.01). …”

Table 1_Global, regional and national patterns and gender disparity of intraocular foreign bodies from 1990 to 2021.doc by Yi Shan (160293)

“…</p>Results<p>The total all-age prevalence and DALYs due to IOFBs rose by 41.9 and 35.5%, respectively, from 1990 to 2021, and the age-standardized prevalence and DALYs rates decreased by 15.2 and 19.6%. The IOFBs burden was greater among middle-aged and older adult men, especially in 45–49 years. …”

Data Sheet 1_New prognostic features and personalized treatment strategies of mitochondrial related genes in colorectal cancer patients.docx by Qizheng Xu (21077153)

“…Key mitochondrial genes, including SUCLG2, ACACB, OSBPL1A, and TRAP1, have been identified as significant prognostic markers in CRC. The expression of ACACB and OSBPL1A progressively increased, while SUCLG2 and TRAP1 expression decreased in patients. …”