Supplementary Material for: Hypothyroidism promotes microglia M1 polarization by inhibiting BDNF-promoted PI3K-Akt signaling pathway by Zhan Y. (4157410)

“…In BV2 cells, LPS treatment decreased expression of BDNF, IL-10, and Arg1, while BDNF overexpression (BDNF-OE) significantly reversed the inflammation-induced by LPS by repressing iNOS and TNF-α, while increasing IL-10 and Arg1. …”

Image 8_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…Household PM2.5 significantly affected ischemic stroke burdens in low Socio-demographic indices (SDI) regions, whereas ambient PM2.5 had a greater impact in middle, high-middle, and high SDI regions. …”

Table 1_Nanocarrier-mediated RNAi of CYP9E2 and CYB5R enhance susceptibility of invasive tomato pest, Tuta absoluta to cyantraniliprole.docx by Farman Ullah (783297)

“…Notably, nanocarrier-encapsulated dsRNA targeting CYB5R and CYP9E2 genes significantly reduced their expression levels. Further, the activity of cytochrome P450 was substantially decreased after the knockdown of the CYB5R and CYP92 genes. …”

Table 5_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.xlsx by Yunyan Lu (10699005)

“…Household PM2.5 significantly affected ischemic stroke burdens in low Socio-demographic indices (SDI) regions, whereas ambient PM2.5 had a greater impact in middle, high-middle, and high SDI regions. …”

Table 10_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.xlsx by Yunyan Lu (10699005)

“…Household PM2.5 significantly affected ischemic stroke burdens in low Socio-demographic indices (SDI) regions, whereas ambient PM2.5 had a greater impact in middle, high-middle, and high SDI regions. …”

Image 3_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…Household PM2.5 significantly affected ischemic stroke burdens in low Socio-demographic indices (SDI) regions, whereas ambient PM2.5 had a greater impact in middle, high-middle, and high SDI regions. …”

Image 5_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…Household PM2.5 significantly affected ischemic stroke burdens in low Socio-demographic indices (SDI) regions, whereas ambient PM2.5 had a greater impact in middle, high-middle, and high SDI regions. …”

Image 4_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…Household PM2.5 significantly affected ischemic stroke burdens in low Socio-demographic indices (SDI) regions, whereas ambient PM2.5 had a greater impact in middle, high-middle, and high SDI regions. …”

Image 12_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…Household PM2.5 significantly affected ischemic stroke burdens in low Socio-demographic indices (SDI) regions, whereas ambient PM2.5 had a greater impact in middle, high-middle, and high SDI regions. …”

Table 1_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.xlsx by Yunyan Lu (10699005)

“…Household PM2.5 significantly affected ischemic stroke burdens in low Socio-demographic indices (SDI) regions, whereas ambient PM2.5 had a greater impact in middle, high-middle, and high SDI regions. …”

Table 3_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.xlsx by Yunyan Lu (10699005)

“…Household PM2.5 significantly affected ischemic stroke burdens in low Socio-demographic indices (SDI) regions, whereas ambient PM2.5 had a greater impact in middle, high-middle, and high SDI regions. …”

Image 10_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…Household PM2.5 significantly affected ischemic stroke burdens in low Socio-demographic indices (SDI) regions, whereas ambient PM2.5 had a greater impact in middle, high-middle, and high SDI regions. …”

Table 2_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.xlsx by Yunyan Lu (10699005)

“…Household PM2.5 significantly affected ischemic stroke burdens in low Socio-demographic indices (SDI) regions, whereas ambient PM2.5 had a greater impact in middle, high-middle, and high SDI regions. …”

Image 11_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…Household PM2.5 significantly affected ischemic stroke burdens in low Socio-demographic indices (SDI) regions, whereas ambient PM2.5 had a greater impact in middle, high-middle, and high SDI regions. …”

Image 1_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…Household PM2.5 significantly affected ischemic stroke burdens in low Socio-demographic indices (SDI) regions, whereas ambient PM2.5 had a greater impact in middle, high-middle, and high SDI regions. …”

Table 8_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.xlsx by Yunyan Lu (10699005)

“…Household PM2.5 significantly affected ischemic stroke burdens in low Socio-demographic indices (SDI) regions, whereas ambient PM2.5 had a greater impact in middle, high-middle, and high SDI regions. …”

Table 6_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.xlsx by Yunyan Lu (10699005)

“…Household PM2.5 significantly affected ischemic stroke burdens in low Socio-demographic indices (SDI) regions, whereas ambient PM2.5 had a greater impact in middle, high-middle, and high SDI regions. …”

Image 13_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…Household PM2.5 significantly affected ischemic stroke burdens in low Socio-demographic indices (SDI) regions, whereas ambient PM2.5 had a greater impact in middle, high-middle, and high SDI regions. …”

Image 7_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…Household PM2.5 significantly affected ischemic stroke burdens in low Socio-demographic indices (SDI) regions, whereas ambient PM2.5 had a greater impact in middle, high-middle, and high SDI regions. …”

Image 9_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…Household PM2.5 significantly affected ischemic stroke burdens in low Socio-demographic indices (SDI) regions, whereas ambient PM2.5 had a greater impact in middle, high-middle, and high SDI regions. …”