Image 2_Integrative multi-omics analysis and experimental validation identify molecular subtypes, prognostic signature, and CA9 as a therapeutic target in oral squamous cell carcin... by Yun Zhao (48978)

“…In vitro experiments validated CA9 as a promising therapeutic target, with its knockdown significantly inhibiting OSCC cell proliferation and migration.…”

Table 2_Integrative multi-omics analysis and experimental validation identify molecular subtypes, prognostic signature, and CA9 as a therapeutic target in oral squamous cell carcin... by Yun Zhao (48978)

“…In vitro experiments validated CA9 as a promising therapeutic target, with its knockdown significantly inhibiting OSCC cell proliferation and migration.…”

Image 3_Integrative multi-omics analysis and experimental validation identify molecular subtypes, prognostic signature, and CA9 as a therapeutic target in oral squamous cell carcin... by Yun Zhao (48978)

“…In vitro experiments validated CA9 as a promising therapeutic target, with its knockdown significantly inhibiting OSCC cell proliferation and migration.…”

Fos does not interact with Jun but homodimerizes post axotomy. by Gibarni Mahata (19486154)

“…(C) Representative images of FosCC-JunVN BiFC in Class I sensory neurons at the basal state, 6 and 24 hpi. …”

Data Sheet 1_Analysis of temporal and spatial changes in the global burden of hypertensive heart disease based on data from the Global Burden of Disease study database and future p... by Guoliang Gao (2910503)

“…The incidence in females was marginally greater than that in males, yet there were comparable decreases in deaths and DALYs for both sexes. There was a notable increase in prevalence in regions with high SDIs, whereas areas with low SDIs experienced greater disease burdens. …”

Data Sheet 1_Assessing ecological environmental quality and conservation effectiveness in the World’s largest urban green heart using the remote sensing ecological index (RSEI) and... by Chongbo Wu (22135075)

“…The findings reveal that: (1) The RSEI demonstrated an average annual growth rate of 0.0038 years^-1 over 31 years, with significant increases during 1990–2013 (0.0045 years^-1) and 2013–2020 (0.0089 years^-1). (2) Comparing pre- and post-GH policy implementation periods (1990–2013 vs. 2013–2020), areas showing EEQ improvement increased from 77.15% to 89.69%, while areas with stable and decreased EEQ declined from 22.36% to 10.17%. (3) GH policy demonstrates substantial positive conservation effects, with both GH and the 3 km buffer zone exhibiting EEQ improvements. …”

Inclusion and exclusion table. by Tong-jie Yang (20939652)

“…</p><p> Conclusion </p><p>(1) HU can effectively contribute to the evaluation of bone and soft tissue densities in the proximal femur, and reflect local stress changes. (2) In ONFH patients, bone density does not decrease in the necrotic area of the femoral head before collapse. …”

Included studies. by Tong-jie Yang (20939652)

“…</p><p> Conclusion </p><p>(1) HU can effectively contribute to the evaluation of bone and soft tissue densities in the proximal femur, and reflect local stress changes. (2) In ONFH patients, bone density does not decrease in the necrotic area of the femoral head before collapse. …”

Inclusion and exclusion criteria. by Tong-jie Yang (20939652)

“…</p><p> Conclusion </p><p>(1) HU can effectively contribute to the evaluation of bone and soft tissue densities in the proximal femur, and reflect local stress changes. (2) In ONFH patients, bone density does not decrease in the necrotic area of the femoral head before collapse. …”

Forest plots comparing demographic factors within SARS-CoV-2 variant waves. by Rebecca M. Cantu (19787070)

“…Confidence intervals that do not cross 1 on the x-axis are considered significant, with higher numbers associated with increased chances for hospitalization and lower numbers with decreased chances for hospitalization.…”

Data Sheet 1_Red mite (Panonychus citri) attack amplifies citrus rootstock-driven responses in physiological and biochemical traits, VOC emission, and expression of defence-related... by Tommy Rioja (22179742)

“…Photosynthetic pigments declined across all combinations after infestation, while soluble sugars and flavonoids decreased in susceptible rootstocks. VOC profiles shifted both qualitatively and quantitatively in a rootstock-dependent manner. …”

Data Sheet 1_Galangin ameliorates PTU-induced vitiligo in zebrafish and B16F10 cells by increasing melanogenesis through activation of the p38/JNK MAPK pathway.pdf by Zulipikaer Wusiman (20852138)

“…In addition, transcriptome analysis indicated that GA likely acts through the mitogen-activated protein kinase (MAPK) signaling pathway. GA has a strong binding affinity for important targets.GA significantly increased the expression of genes such as mapk8b, mapk14a, mapk3, mitf, tyr, tyrp1b, tyrp1a, dct, and oca2, and decreased the expression of genes such as expression of genes such as raf1 and egfr. …”

Effect of miR-7974 mimic transfection on proliferation of MDA-MB-453 cells together with changes in protein and gene expression levels of LC3B. by Stralina Eneh (21213312)

“…<b>(C)</b> The gene expression levels of <i>LC3B</i> were decreased 72h after miR-7974 transfection of MBA-MB-453 cells compared to the negative control/cells-only samples. …”

Table 1_Hemerocallis citrina Baroni leaf total phenol alleviates depressive-like behaviors via modulating “microbiota-gut-brain” axis in chronic unpredictable mild stress -induced... by Yanping Wang (275956)

“…It also decreased the inflammatory factor (TNF-α and IL-1β) in the brain, as well as corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and corticosterone (CORT) in serum and brain. …”

Table1_Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer’s d... by Huijing Ren (19986303)

“…The results demonstrated that the combined administration of these 4 components (CPGB) had superior mitigating effects on AD cell model, as evidenced by the reduced pro-inflammatory cytokine production and decreased deposition of Aβ protein. Further in vivo and in vitro experiments confirmed that varying doses of CPGB formula effectively ameliorated STZ-induced cognitive deficits, as shown by NOR, MWM, and EMP tests, as well as pathological changes in hippocampal tissues and a 3-dimensional brain neurovascular unit (3D-NVU) model, including decreased deposition of Aβ protein and formation of plaques. …”

Comparison of the trend of people’s perceptions and the climatic trends (social data: Quantitative data: Household survey (n = 660); qualitative data: Focus group discussions (n =... by Parbati Phuyal (8687400)

“…Brackets indicate only a small trend (climate = one or a few significant indices, temporal shift = no significant trend). …”

Table 1_Dietary quercetagetin attenuates H2O2-induced oxidative damage and preserves meat quality in broilers by modulating redox status and Nrf2/ferroptosis signaling pathway.docx by Wenyue Hu (799025)

“…Compared with the control group, the mRNA expressions of glutathione peroxidase (GSH-Px), NAD(P)H quinone dehydrogenase 1 (NQO1), catalase (CAT), nuclear factor erythroid 2-related factor 2 (Nrf2), transferrin receptor protein 1 (TFR1), and ferritin heavy chain 1 (FTH1) in the breast muscle were decreased (p < 0.05). …”

Image1_Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer’s d... by Huijing Ren (19986303)

“…The results demonstrated that the combined administration of these 4 components (CPGB) had superior mitigating effects on AD cell model, as evidenced by the reduced pro-inflammatory cytokine production and decreased deposition of Aβ protein. Further in vivo and in vitro experiments confirmed that varying doses of CPGB formula effectively ameliorated STZ-induced cognitive deficits, as shown by NOR, MWM, and EMP tests, as well as pathological changes in hippocampal tissues and a 3-dimensional brain neurovascular unit (3D-NVU) model, including decreased deposition of Aβ protein and formation of plaques. …”

Supplementary file 1_Shaoyao gancao decoction induces autophagy by modulating miR-21 and inhibiting the AKT/mTOR signaling pathway in adenomyosis-derived ectopic endometrial stroma... by Huijie Lai (22696685)

“…</p>Results<p>In ectopic endometria of AM, there was a significant increase in miR-21 mRNA expression as well as heightened activity within the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway. …”

Table 1_Assessing the effects of the COVID-19 pandemic on new ART initiation and viral load access among children and adolescents living with HIV in West Africa: an interrupted tim... by Yao Rodion Konu (9617259)

“…There were no significant trends in the number of ART initiations during the pandemic, except in Ghana (IRR: 1.146 [1.073–1.224]). …”