6:2 Chlorinated Polyfluoroalkyl Ether Sulfonate (F-53B) Induces Aging and Parkinson’s Disease-like Disorders in <i>C. elegans</i> at Low Concentrations by Hui Li (32376)

“…Such oxidative stress led to notable mitochondrial damage as gene expression related to mitochondrial morphology and function including <i>pink1, pdr-1, fis1</i>, and <i>djr</i> was significantly suppressed in all exposure groups, which could contribute to the aging and PD-like disorders observed above as ROS and mitochondrial dysfunction were well demonstrated to be important inducers for aging and PD. …”

6:2 Chlorinated Polyfluoroalkyl Ether Sulfonate (F-53B) Induces Aging and Parkinson’s Disease-like Disorders in <i>C. elegans</i> at Low Concentrations by Hui Li (32376)

“…Such oxidative stress led to notable mitochondrial damage as gene expression related to mitochondrial morphology and function including <i>pink1, pdr-1, fis1</i>, and <i>djr</i> was significantly suppressed in all exposure groups, which could contribute to the aging and PD-like disorders observed above as ROS and mitochondrial dysfunction were well demonstrated to be important inducers for aging and PD. …”

6:2 Chlorinated Polyfluoroalkyl Ether Sulfonate (F-53B) Induces Aging and Parkinson’s Disease-like Disorders in <i>C. elegans</i> at Low Concentrations by Hui Li (32376)

“…Such oxidative stress led to notable mitochondrial damage as gene expression related to mitochondrial morphology and function including <i>pink1, pdr-1, fis1</i>, and <i>djr</i> was significantly suppressed in all exposure groups, which could contribute to the aging and PD-like disorders observed above as ROS and mitochondrial dysfunction were well demonstrated to be important inducers for aging and PD. …”

Summary of miRNAs sequencing data quality. by Zhaowen Tan (12283502)

“…After training, total RNA was extracted from the left ventricular myocardium of rats in the SHR-SED group and the BFRT group, miRNAs were sequenced, followed by GO enrichment and KEGG pathway analyses, and the differentially expressed miRNAs were subsequently validated via qRT‒PCR.</p><p>Results</p><p>1) Hemodynamic tests revealed that the blood pressure of SHRs in the BFRT decreased significantly and that the blood pressure level of SHRs in the BFRT decreased more significantly than that of the simple resistance training groups did (P < 0.05). 2) Cardiac function tests revealed that the EF, FS, and MV E/A of SHRs in the BFRT significantly increased, whereas the HR, IVSd, IVSs, LVIDd, LIVDs, LVPWd, LVPWs and LV mass significantly decreased (P < 0.05). 3) Transcriptome sequencing revealed 9 differentially expressed miRNAs in the BFRT group compared with the SHR-SED group (2 miRNAs were significantly upregulated, and 7 miRNAs were significantly downregulated), with P < 0.05 and |log2FoldChange| ≥ 1 used as the criteria for differential significance. …”

The miRNA target genes. by Zhaowen Tan (12283502)

“…After training, total RNA was extracted from the left ventricular myocardium of rats in the SHR-SED group and the BFRT group, miRNAs were sequenced, followed by GO enrichment and KEGG pathway analyses, and the differentially expressed miRNAs were subsequently validated via qRT‒PCR.</p><p>Results</p><p>1) Hemodynamic tests revealed that the blood pressure of SHRs in the BFRT decreased significantly and that the blood pressure level of SHRs in the BFRT decreased more significantly than that of the simple resistance training groups did (P < 0.05). 2) Cardiac function tests revealed that the EF, FS, and MV E/A of SHRs in the BFRT significantly increased, whereas the HR, IVSd, IVSs, LVIDd, LIVDs, LVPWd, LVPWs and LV mass significantly decreased (P < 0.05). 3) Transcriptome sequencing revealed 9 differentially expressed miRNAs in the BFRT group compared with the SHR-SED group (2 miRNAs were significantly upregulated, and 7 miRNAs were significantly downregulated), with P < 0.05 and |log2FoldChange| ≥ 1 used as the criteria for differential significance. …”

Differential miRNA target gene pathway enrichment bubble map. by Zhaowen Tan (12283502)

Distinct effects on calcium channel activation of <i>CACNA1I</i> disease-associated amino acid substitutions A398E/V and M1425V/I. by Yousra El Ghaleb (22075892)

Semiannual analysis of monthly use of sterile blood transfer devices. by Miki Doi (15347878)

Semiannual analysis of monthly use of skin disinfection swab sets in the hospital. by Miki Doi (15347878)

Changes in the monthly contamination rate (per set) in blood culture (BC). by Miki Doi (15347878)

Water level changes in the foresight scenarios. by Zihao Duan (17403792)

“…Compared to 1930, the water level decreased by 2.6 m by 2023, with 1935 marking the onset of a significant downward trend. …”

Water level changes in the Caspian Sea. by Zihao Duan (17403792)

“…Compared to 1930, the water level decreased by 2.6 m by 2023, with 1935 marking the onset of a significant downward trend. …”

Methods used to extract shoreline changes. by Zihao Duan (17403792)

“…Compared to 1930, the water level decreased by 2.6 m by 2023, with 1935 marking the onset of a significant downward trend. …”

Morlet wavelet power spectrum of the sea level. by Zihao Duan (17403792)

“…Compared to 1930, the water level decreased by 2.6 m by 2023, with 1935 marking the onset of a significant downward trend. …”

Coastal area changes during the period 1985–2023. by Zihao Duan (17403792)

“…Compared to 1930, the water level decreased by 2.6 m by 2023, with 1935 marking the onset of a significant downward trend. …”

Genomic downregulation of TGF β1 production in monocytes obtained after RZV administration. Panel A. The heatmap shows 16 genes on the y axis whose accessibility significantly changed between Days 0 and 90 after vaccination (FDR p < 0.1) in 8 participants shown on the x axis. Note decreased accessibility of the <i>TGFβ1</i> gene. Panel B.... by Michael J. Johnson (5818168)

“…Note decreased accessibility of the <i>TGFβ1</i> gene. Panel B. …”

Co-infected cells express both KSHV and EBV genes <i>in vitro</i> necessary for their survival and growth. by Mitchell Hayes (5334887)

BMISES_Data_Part1. by Krystal Hunter (6820052)

Blocking IFNAR leads to enhancement of IL-1β and IL-17 production. by Madhusoodhanan Suresh Kumar Meena Kumari (20896666)

Gsdmd deficiency reduces myeloid cell recruitment to the liver during schistosome infection. by Madhusoodhanan Suresh Kumar Meena Kumari (20896666)