Data Sheet 1_Cordycepin attenuates NLRP3/Caspase-1/GSDMD-mediated LPS-induced macrophage pyroptosis.pdf by Zige Liu (20724752)

“…The results demonstrated that cordycepin exhibits strong binding affinity for NLRP3, Caspase-1, and GSDMD. Cordycepin pre-treatment significantly reduced ROS levels and XO activity, inhibited the expression of NLRP3, cleaved-Caspase-1, and cleaved-GSDMD, and decreased pyroptosis-associated inflammatory cytokines IL-1β and IL-18, along with Caspase-1 activity. …”

Data Sheet 1_Role of RGS17 in cisplatin-induced cochlear inflammation and ototoxicity via caspase-3 activation.zip by Raheem F. H. Al Aameri (14951800)

“…One of its significant side effects is ototoxicity, especially when high doses are required. …”

<b>Mass, Residency Duration, and Previous Experience Shape Post-Escalation but Not Pre-Escalation Outcomes in Experimental Territorial Contests of Atlantic Mudskippers (</b><b><i>P... by Michael Smith (21714377)

“…We investigated predictors of dyadic contest outcomes in the Atlantic mudskipper (<i>Periophthalmus barbarus</i>) using a modified resident-intruder design that physically separated the contestants before physical contact, allowing separate investigation of pre-escalation (resident’s decision to engage) and post-escalation (contest resolution) complementary outcomes. …”

Data Sheet 1_Efficacy and safety of anlotinib combined with 125I seed implantation for iodine-refractory thyroid cancer.docx by Zhijun Chen (254277)

“…Background and objective<p>Radioiodine-refractory differentiated thyroid cancer (RAIR-DTC) remains challenging to treat due to a lack of effective therapies. This study aimed to evaluate the efficacy and safety of combining anlotinib with iodine-125 (¹²⁵I) seed implantation in patients with RAIR-DTC.…”

Data Sheet 2_BNIP3-mediated mitophagy aggravates placental injury in preeclampsia via NLRP1 inflammasome.pdf by Man Zhao (314232)

“…Furthermore, silencing BNIP3 leads to a significant reduction in mitochondrial damage and mtROS production. …”

The Type I JAKinib, ruxolitinib, promotes pJAK1 and pJAK2 phosphorylation in MSCs from salivary glands. by Ilya Gurevic (1326786)

“…(E-G) were performed with replicates (n = 6; 3 SjD and 3 control) of our treatment conditions on the right with a representative western on the left; (E) pJAK1 proportion increased in a dose-dependent manner with increasing ruxolitnib; (F) pJAK2 proportion increased as ruxolitinib dose increased; (G) pSTAT1 decreased in a dose response relationship with increasing ruxolitinib. …”

Supplementary Material for: Feedback from human instructors is superior to guidance by a virtual reality simulator when learning flexible bronchoscopy – a randomized controlled tri... by figshare admin karger (2628495)

“…[Results] All three groups showed an improvement in SP, DC, PT and NASA-TLX during their 12 procedures (P<.05), without a decrease in performance three weeks later (P>0.05). …”

Table1_Assessing physical fitness adaptations in collegiate male soccer players through training load parameters: a two-arm randomized study on combined small-sided games and runni... by YanXiu Quan (19645810)

“…Although there were positive trends in variables such as RSA and 30-15IFT, these changes were modest and not statistically significant. The results suggest that while the combined SSGs and HIIT approach shows potential, its impact on physical fitness over a 4-week period is limited, with some variables, like CMJ, even showing decreases.…”

Localization and expression of cell-to-cell connection proteins in bma-miRNA transfected and NC hLECs. by Hailey Johnson (18217167)

“…(<b>I</b><b>–</b><b>K)</b> ITGB1 (red) expression appears similar across treatment groups (I – NC, J – bma-miR-5864, and K – bma-mir-86), with mildly decreased expression observed in parasite miRNA-treated cells (J, K). …”

Image 2_One-year post lockdown trajectories of mental health and impact of COVID-19 lockdown-related factors.jpeg by Mathilde Mongeau (20864315)

“…</p>Results<p>Our analysis revealed a significant decrease in the proportion of individuals experiencing poor mental health (elevated GAD-7 or PHQ-9 > 4) from lockdown period to 1 month and 6 months post-lockdown. …”

Figure 7 from KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma by Elisabet Figuerola-Bou (22618659)

“…<p>KDM6B KO decreases tumor growth. <b>A,</b> Colony formation assay of KDM6B KO cells (sgRNA#1 and sgRNA#2) compared with parental and sgCTRL A-673 cells. …”

Data Sheet 1_Tcirg1 deficiency delays osteoarthritis progression by impairing lysosome acidification and peripheral accumulation in osteoclasts.docx by Rui Sun (177521)

“…“T-cell immune regulator 1” (Tcirg1), which encodes the a3 subunit of the V-ATPase, has been demonstrated to inhibit the formation of large osteoclasts by reducing intracellular calcium oscillations. …”

Supplementary file 1_Comparison of the ruminal microbiome responses of temperate and tropically adapted beef steers to dietary supplementation with monensin.docx by Ross L. Thorn (22688840)

“…A total of 10 steers each of the Angus, Brahman, and F1 (Angus × Brahman) breed types were fed forage ± a monensin ionophore supplement. …”

Assessing Quality of Referrals to a Community-Based Chronic Pain Clinic by Angela Mailis (19960223)

“…Half of the non-resubmitted referrals could have been accepted if the referring provider had sent in the missing information.</p> <p>A significant number of referrals to our pain clinic (primarily from PCPs) are rejected for mainly avoidable reasons. …”

Enteropathogen detection and fCal levels. by Muhammad Rehan (406524)

“…Select enteric pathogens, including <i><i>Shigella</i></i>, commonly cause disease in high-burden settings; targeted treatment of these pathogens could decrease morbidity and mortality. …”

Table 1_Research on the effect of LAMP1 in the development and progression of ccRCC and its potential mechanism with LC3C-mediated autophagy.docx by Xiongbao Wang (12508462)

“…Background<p>Lysomembrane-associated protein 1 (LAMP1), known to exhibit differential expression in various tumor types and play a crucial role in the development of tumors. …”

Data Sheet 1_Research on the effect of LAMP1 in the development and progression of ccRCC and its potential mechanism with LC3C-mediated autophagy.docx by Xiongbao Wang (12508462)

“…Background<p>Lysomembrane-associated protein 1 (LAMP1), known to exhibit differential expression in various tumor types and play a crucial role in the development of tumors. …”

Beta cell function derived from routine clinical measures reports and predicts treatment response to immunotherapy in recent-onset type 1 diabetes. by Michelle So (400874)

“…A 6.2% decrease in Beta2 score at week 12 predicted significant improvement in HbA1c (-0.6% or -6 mmol/mol) and insulin use (-0.26 units/kg/day) in combined data from the rituximab, abatacept and anti-thymocyte globulin trials.…”

Data Sheet 1_Serum VEGF and ANGPT1 as angiogenesis markers may predict the outcomes of older adults with hip fractures.xlsx by Yuan Yao (31223)

“…Kaplan–Meier survival analysis revealed that low levels of VEGF and ANGPT1 were significantly associated with decreased survival probability. …”

Data Sheet 1_Effects of Th1/Th17 and Th2 cytokines on lipid metabolism in differentiated keratinocytes.zip by Alessia Cavallo (13036581)

“…Th2 cytokines caused a generalized decrement of free FAs, including long-chain ones. …”