Discovery of MKP10241, a Novel Small Molecule Targeting the GPR119/Incretin Axis to Treat Metabolic Disorders by Santosh Kumar Rai (22382996)

“…We have developed a potent GPR119 agonist, MKP10241, which has elevated cyclic adenosine monophosphate (cAMP) levels in the GPR119 expressing cell line and reduced blood glucose levels and HbA1c in acute models and a chronic diabetic mouse model. …”

Table 1_The prevalence and correlates of falls in adults with attention-deficit/hyperactivity disorder: cross-sectional study.docx by Maraheb M. Alkhalidi (22389535)

Table 1_Circulating microRNA signatures as potential biomarkers differentiating diabetic, prediabetic, and healthy individuals.docx by Hanifa J. Abu-Toamih Atamni (22555724)

“…Correlation analyses highlighted miRNAs associated with glucose/HbA1c, alongside relationships among vitamin D status, glycemia, and platelet function.…”

Data Sheet 1_Wooden breast myopathy is characterized by satellite cell dysfunction and syndecan-4 shedding.pdf by Lucie Pejšková (20467025)

Table 1_Effects of supplemental feeding of Chinese herbal mixtures to perinatal sows on reproductive performance, immunity, and breast milk quality of sows.docx by Xuelei Duan (19650700)

“…Supplemental feeding of 2 kg/t and/or 3 kg/t QZGSP significantly elevated levels of IL-4, IL-10, IgG, and IgA in sow serum while reduced levels of TNF-α and IL-1β in sow serum. …”

Table 1_Effects of perinatal nutrition supplementation and early weaning on serum biochemistry, metabolomics, and reproduction in yaks.docx by Kaiyuan Shang (20453966)

“…The serum levels of metabolic regulatory hormones, including insulin, leptin, and insulin-like growth factor I were significantly increased, and glucagon was significantly reduced in the SF and SW groups than in the GF group at −15 and 30 d. …”

Image 1_Myo-inositol improves developmental competence and reduces oxidative stress in porcine parthenogenetic embryos.tif by Ali Jawad (1728757)

“…Furthermore, immunofluorescence results indicated that 20 mM Myo-Ins significantly increased HO-1 expression in blastocysts compared to the control group.…”

Table 1_Myo-inositol improves developmental competence and reduces oxidative stress in porcine parthenogenetic embryos.docx by Ali Jawad (1728757)

“…Furthermore, immunofluorescence results indicated that 20 mM Myo-Ins significantly increased HO-1 expression in blastocysts compared to the control group.…”

Supplementary file 1_Down-regulation of colon mucin production induced by Eimeria pragensis infection in mice.pdf by Yulia Dwi Setia (21590591)

“…Maximal parasite accumulation in the proximal colon was observed at 8 dpi in histological examination as well as qPCR. Colon length was significantly shortened at 3 dpi. Goblet cell area significantly reduced at 8 dpi (p < 0.05). …”

Image 1_Augmentation of bone formation by sympathectomy in rats as evaluated by [99mTc]Tc-MDP.png by Zili Cai (15238729)

“…</p>Materials and methods<p>Twenty rats were randomly assigned to a superior cervical ganglionectomy (SCGx) group (n = 10) or a sham-operated control group (n = 10). …”

Table 1_Association between sedentary behavior, physical activity, and osteoarthritis: results from NHANES 2007–2020 and Mendelian randomization analysis.xls by Jiangqin He (18852987)

“…MR analysis indicated that genetically inferred SB was associated with a higher likelihood of OA (IVW OR 1.20, 95% CI 1.13–1.28), while increased PA was inversely associated with OA risk (IVW OR 0.85, 95% CI 0.73–0.98).…”

Table 1_The development of the neurosurgery workforce in Austria over the past quarter century: is more always better?.xlsx by Mario Mischkulnig (11659318)

“…Regional disparities were pronounced, with Salzburg reaching 6.51 neurosurgeons per 100,000 while Burgenland registered its first only in 2012 and still shows the nationwide lowest density of 1.00 per 100,000.</p>Conclusion<p>Austria has experienced rapid workforce growth without a parallel rise in neurosurgical case volume, resulting in declining operative exposure per surgeon. …”

Supplementary file 1_Akkermansia muciniphila alleviates cognitive impairment and neuroinflammation induced by blunt chest trauma.docx by Lin Liu (74495)

“…AKK also modulated the expression of metabolites linked to neuroinflammation and cognitive function, upregulated BDNF and TrkB, and decreased IBA1, suggesting it enhances cognitive function by modulating neuroinflammation and the BDNF/TrkB signaling pathway.…”

Data Sheet 1_Experimental study on the correlation between pore evolution characteristics and seepage flow of loaded lignite.xlsx by Xi Zhang (83736)

“…The aggregation of water image signals reflects the distribution area of pores that dominate seepage. (3) Under uniaxial compression, the pore change rate S_i slightly decreased. The pore change rate S_i of medium pores and macropores showed a positive correlation with axial pressure, which is consistent with the total pore change trend. …”

Image 2_Practical utility of meropenem therapeutic drug monitoring: a systematic review of evidence for clinical application.pdf by Yi-Chang Zhao (14080107)

“…Adverse reactions showed a non-significant reduction (RR = 0.65; 95% CI: 0.38–1.11). …”

Table 1_Burden of esophageal cancer in global, regional and national regions from 1990 to 2021 and its projection until 2050: results from the GBD study 2021.docx by Chengcheng Zhang (725743)

“…DALYs totaled 12,999,264, corresponding to an estimated annual percentage change (EAPC) of a 1.73% decrease in the age-standardized DALYs rate. …”

Table_1_RETRACTED: miR-335 Targets LRRK2 and Mitigates Inflammation in Parkinson’s Disease.DOCX by Sara R. Oliveira (10972152)

Data Sheet 1_HDL from 36-h fasted participants potently promotes efflux of cholesteryl ester from activated microglia.zip by Joanne K. Agus (12889409)

“…In exploring differences among HDL parameters from postprandial, overnight fasted, and 36-h fasted individuals, we observed that plasma HDL-cholesterol and apolipoprotein A-I concentrations remained unchanged. However, nuclear magnetic resonance (NMR) analysis revealed reduced total HDL particle count, a decrease in the smallest HDL particles (HDL1, 7.4 nm diameter), and an increase in the largest HDL particles (HDL7, 12 nm) after the 36-h fast. …”

Supplementary file 1_Age-period-cohort analysis of syphilis epidemics in Eastern China, China, 2005–2024.docx by Zheyuan Ding (4281394)

“…The cohort effect shows that the risk decreased in later birth cohorts, with the highest reported incidence risk in the birth cohort of 1960–1964 (RR = 1.30; 95% CI: 1.08, 1.57) and the lowest risk in the birth cohort of 2020–2024 (RR = 0.00; 95% CI: 0.00, 0.18).…”

Data Sheet 1_Changes in cortical brain activity after active break in preschoolers: MOVI-HIIT study.pdf by María Valdivieso-González (22225891)

“…</p>Results<p>EEG data revealing significant increases in Theta, Alpha1, and Alpha2 bands, suggesting enhanced relaxation, attentiveness, and readiness to learn. …”