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12581
Image 3_Transcutaneous auricular vagus nerve stimulation alleviates inflammation-induced depression by modulating peripheral-central inflammatory cytokines and the NF-κB pathway in...
Published 2025“…Serum analysis revealed that pro-inflammatory cytokines (e.g., IL-1β, TNF-α, MCP-1, IL-18, MIP-1α, and MIP-3α) were markedly elevated, while anti-inflammatory cytokines IL-4 and IL-10 were significantly reduced in the model group. taVNS intervention reversed these changes. …”
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12582
HDX profile changes of βarr2 upon co-incubation with C7pp2.
Published 2025“…Differences smaller than 0.2 Da were not considered significant. The data underlying the graphs shown in the figure can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003312#pbio.3003312.s009" target="_blank">S1 Data</a>.…”
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12583
Figure 4 from Functional Profiling of p53 and RB Cell Cycle Regulatory Proficiency Suggests Mechanism-Driven Molecular Stratification in Endometrial Carcinoma
Published 2025“…<b>B,</b> HEC1B and ARK1 cells were treated with vehicle (DMSO) or a dose curve of the CDK1 inhibitor (CDK1i) Ro-3306 for 16 hours. …”
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12584
Prolonged sitting time and all-cause mortality: the mediating and predictive role of kidney function markers
Published 2025“…There was a significant increase in the levels of blood urea nitrogen (BUN), creatinine, uric acid, osmolality, and UACR with extended daily sitting time, while eGFR significantly decreased. …”
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12585
Neurochemical identity of dFB<sup>23E10</sup>Ո<sup>84C10</sup> neurons.
Published 2025“…<b>(D)</b> Representative confocal stack of a female <i>84C10-AD; Gad1-DBD>UAS-mCD8GFP</i>. …”
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12586
ZNF503-AS2 had predictive value for chemotherapy and immunotherapy in glioma.
Published 2024“…NS, not statistically significant; * <i>P</i> < 0.05; ** <i>P</i> < 0.01; *** <i>P</i> < 0.001.…”
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12587
Improved antidiabetic potential of quercetin-loaded chitosan–lecithin nanoparticles for effective glycaemic control
Published 2025“…</p> <p>The optimised QTN/LCHS-NP formulation exhibited 79.72% �, diameter of 130.1 nm, and a ZP of 23.46 mV. <i>In vitro</i> release studies showed a biphasic pattern, with an initial burst release followed by a sustained release of 86.10% over 24 h. …”
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12588
Association between Lyn tyrosine kinase and renal injury in patients with systemic lupus erythematosus
Published 2025“…ROC curve analysis suggested Lyn as a reliable predictor for SLE, LN, and lupus activity, with histopathological examination revealing that decreased Lyn expression correlated negatively with the renal pathology index (<i>r</i> = −0.8016, <i>p</i> = 0.0016).…”
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12589
Supplementary Material for: Impacts of air pollution on dynamic lung function in asthma patients: the modifying effect of phenotype susceptibility and possible relationship with ai...
Published 2025“…Induced sputum from these subjects was collected and analyzed for the microbiome composition and associations between microbiome and lung function indices. Results We found that a 10 μg/m3 increase in PM2.5 was associated with decreases 0.79% in FEF25-75 (95% CI: 0.31 ~ 3.25), a range of decreases of 0.76%~0.83% PEF, 1.58%~1.93% for FEF25 and 1.79%~2.31% for FEF50 in the morning or evening on different lag days. …”
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12590
Heterogeneity dynamics: influencing rock type responses to overburden pressure, Permian–Triassic of the Persian Gulf
Published 2025“…Findings showed limestone’s frequent rock type changes under reservoir pressure <i>via</i> the Winland method, while dolomite samples showed significant alterations using the flow zone indicator method. …”
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12591
The global disability-adjusted life years (DALYs) for asthma attributable to nitrogen dioxide pollution from 1990 to 2021 and predicted the trends from 2022 to 2050
Published 2025“…</p> <p>The global age-standardized DALYs rate (ASDALYs) decreased from 4.80 [95%<i>UI</i>: −4.29 to 17.75] in 1990 to 2.48 [95%<i>UI</i>: −2.26 to 10.30] in 2021. …”
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12592
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12593
Microbiome-host genetic association.
Published 2025“…Core microbiome and correlation analysis at the phylum and genus levels identified significant microbiota. Specifically, the abundance of genera such as <i>Pseudomonas</i> and <i>Akkermansia</i> decreased, while <i>Ruminococcus</i> and <i>Allistipes</i> increased, as determined by statistical and machine learning approaches. …”
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12594
Summary description of the samples.
Published 2025“…Core microbiome and correlation analysis at the phylum and genus levels identified significant microbiota. Specifically, the abundance of genera such as <i>Pseudomonas</i> and <i>Akkermansia</i> decreased, while <i>Ruminococcus</i> and <i>Allistipes</i> increased, as determined by statistical and machine learning approaches. …”
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12595
Azole drugs have differential efficacy in varied models of immunosuppression in larval zebrafish hosts
Published 2025“…Repeated daily imaging of whole live larvae treated with posaconazole demonstrates that posaconazole treatment can prevent germination of <i>A. fumigatus</i> spores inside infected hosts but that this drug does not significantly combat fungal hyphal growth post-germination.…”
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12596
CCDC66 localizes to the axoneme and regulates primary cilium stability but not cilia formation in IMCD3 cells.
Published 2025“…Ciliary vesicle ectocytosis or fragments were categorized based on the size of the released EVs, vesicle < 500 nm and fragment > 500 nm, and plotted as a bar plot. (<i>p</i> values of Welch’s <i>t</i> test, **<i>p</i> = 0.0074, ***<i>p</i> = 0.0007, ns = not significant). …”
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12597
CRISPR/Cas9-mediated editing of barley lipoxygenase genes promotes grain fatty acid accumulation and storability
Published 2025“…Notably, the total LOX activity in mature grains decreased by 36–42% in <i>loxC1</i> mutants and by 94% in <i>loxAloxC1</i> mutants, with no significant change observed in <i>loxB</i> mutants. …”
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12598
DataSheet2_Mineral nutrition for Cannabis sativa in the vegetative stage using response surface analysis.docx
Published 2024“…N × K interaction had a significant effect on leaf mass and stem mass. …”
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12599
CLAD_sequence_files
Published 2025“…</b>BALF metabolomes varied by underlying disease state, with AATD LT recipients being particularly distinctive (PERMANOVA, <i>p</i>= 0.001, F= 3.91). We also found a significant association with the final CLAD severity score (RF variance explained = 11.08%, PERMANOVA, <i>p</i>=0.001), especially those with underlying CF. …”
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12600
Osseointegration of an innovative functionally gradient biomimetic scaffold based on Voronoi-Tessellation for the design of orthopaedic implants
Published 2025“…<p>The geometry and pore size of porous structures have a significant impact on osseointegration in orthopaedic implant design. …”