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12821
Video 3_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4
Published 2025“…Multi-omics analysis revealed that TPC2 KO disrupted amino acid metabolism, glycolysis, and protein translation, resulting in reduced ERK1/2 expression and impaired MAPK signalling. These metabolic and signalling alterations were associated with decreased tumour proliferation and increased MHC-I surface expression.…”
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12822
Video 7_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4
Published 2025“…Multi-omics analysis revealed that TPC2 KO disrupted amino acid metabolism, glycolysis, and protein translation, resulting in reduced ERK1/2 expression and impaired MAPK signalling. These metabolic and signalling alterations were associated with decreased tumour proliferation and increased MHC-I surface expression.…”
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12823
Reduced Aqueous Retinol Binding Protein 3 Concentration is Associated with Diabetic Macular Edema and Progression of Diabetic Retinopathy
Published 2024“…Aqueous RBP3 decreased from a median of 2.1nM [IQR 0.8-3.4nM] in eyes with no DR to 1.5nM [0.8-3.8nM] in eyes with mild-moderate NPDR (P=0.047). …”
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12824
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12825
Supporting data for “Androgen receptor modulates chemotherapy response in breast cancer”
Published 2025“…TRIM37 overexpression decreased palbociclib sensitivity, while its knockdown enhanced sensitivity and attenuated the effect of AR on RB1 levels and drug response, establishing TRIM37 as a novel E3 ligase that bound RB1 via its MATH and C-terminal domains.…”
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12826
Land use intensity classes standard.
Published 2025“…The habitat quality shows a spatial distribution pattern of “high in the surrounding areas and low in the central areas”, and autocorrelation analysis shows that county-level units have significant spatial agglomeration effects. …”
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12827
Data Sheet 3_Pandan–vanilla rotation mitigates Fusarium wilt disease in vanilla: insights from rhizosphere microbial community shifts.xlsx
Published 2025“…Soil pH was identified as a significant factor influencing microbial community assembly. …”
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12828
Land use transfer matrix 1990-2020 (km<sup>2</sup>).
Published 2025“…The habitat quality shows a spatial distribution pattern of “high in the surrounding areas and low in the central areas”, and autocorrelation analysis shows that county-level units have significant spatial agglomeration effects. …”
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12829
Study area habitat quality LISA clustering map.
Published 2025“…The habitat quality shows a spatial distribution pattern of “high in the surrounding areas and low in the central areas”, and autocorrelation analysis shows that county-level units have significant spatial agglomeration effects. …”
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12830
Spato-temporal changes in land use types.
Published 2025“…The habitat quality shows a spatial distribution pattern of “high in the surrounding areas and low in the central areas”, and autocorrelation analysis shows that county-level units have significant spatial agglomeration effects. …”
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12831
Pattern indices of landscape levels.
Published 2025“…The habitat quality shows a spatial distribution pattern of “high in the surrounding areas and low in the central areas”, and autocorrelation analysis shows that county-level units have significant spatial agglomeration effects. …”
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12832
Data Sheet 2_Pandan–vanilla rotation mitigates Fusarium wilt disease in vanilla: insights from rhizosphere microbial community shifts.xlsx
Published 2025“…Soil pH was identified as a significant factor influencing microbial community assembly. …”
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12833
Type level landscape index changes in 1990-2020.
Published 2025“…The habitat quality shows a spatial distribution pattern of “high in the surrounding areas and low in the central areas”, and autocorrelation analysis shows that county-level units have significant spatial agglomeration effects. …”
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12834
Location map of the study area.
Published 2025“…The habitat quality shows a spatial distribution pattern of “high in the surrounding areas and low in the central areas”, and autocorrelation analysis shows that county-level units have significant spatial agglomeration effects. …”
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12835
Data source.
Published 2025“…The habitat quality shows a spatial distribution pattern of “high in the surrounding areas and low in the central areas”, and autocorrelation analysis shows that county-level units have significant spatial agglomeration effects. …”
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12836
Research Technology Flow Chart.
Published 2025“…The habitat quality shows a spatial distribution pattern of “high in the surrounding areas and low in the central areas”, and autocorrelation analysis shows that county-level units have significant spatial agglomeration effects. …”
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12837
Table 2_Differential resilience of chickpea’s reproductive organs to cold stress across developmental stages: insights into antioxidant strategies for enhanced fertility.docx
Published 2025“…Exogenous supplementation with 1 mM ascorbate (AsA) and glutathione (GSH) significantly stimulated pollen germination in cold-stressed plants under in vitro conditions, with a greater effect observed in CS genotypes. …”
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12838
Participants’ Mean Blood Glucose.
Published 2025“…Each year of age increases TC by 0.42 mg/dl and BG by 0.48 mg/dl; ever-married individuals have higher TC (21.8 mg/dl) and BG (8.8 mg/dl) levels; hypertension increases TC by 16.8 mg/dl and BG by 14.5 mg/dl; and higher BMI is associated with increased TC (1.3 mg/dl) and BG (0.9 mg/dl). Moreover, multivariate analysis using multiple linear regression indicates the same result; however, the results of marital status and gender are not significant with BG level and results of education levels, salt intake and any type of physical activity are not significant with TC levels. …”
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12839
Participants’ Mean Total Cholesterol.
Published 2025“…Each year of age increases TC by 0.42 mg/dl and BG by 0.48 mg/dl; ever-married individuals have higher TC (21.8 mg/dl) and BG (8.8 mg/dl) levels; hypertension increases TC by 16.8 mg/dl and BG by 14.5 mg/dl; and higher BMI is associated with increased TC (1.3 mg/dl) and BG (0.9 mg/dl). Moreover, multivariate analysis using multiple linear regression indicates the same result; however, the results of marital status and gender are not significant with BG level and results of education levels, salt intake and any type of physical activity are not significant with TC levels. …”
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12840
Table 8_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.xlsx
Published 2025“…Aberrant crotonylation, a type of epigenetic modification, has been implicated in the proliferation, metastasis, and immune evasion of various cancers. …”