Data Sheet 1_Comparative analysis of proteomics and transcriptomics reveals novel mechanism underlying the antibacterial activity and immune-enhancing properties of horse milk.zip by Xueshan Chen (17477633)

“…Further transcriptome analysis demonstrated that PGL exerted significant transcriptional changes to bacteria. Enrichment analysis showed PGL could inhibit growth of P. aeruginosa and E. coli by repressing the biosynthesis of secondary metabolites.…”

Table 4_Identification and validation for biomarkers associated with mitochondrial metabolism in chronic obstructive pulmonary disease.xlsx by Wenjun Wang (314231)

“…The mRNA and protein expression of APRT and LCAT were significantly decreased in COPD patients’ lung tissues.…”

Image 1_iPSC-derived exosomes as amphotericin B carriers: a promising approach to combat cryptococcal meningitis.tif by Jingyu Zhao (2371618)

“…Background<p>Cryptococcal meningitis (CM) is a significant global health issue, particularly affecting individuals with HIV. …”

Data Sheet 1_Global burden and trend of stroke attributable to metabolic risks among young adults (20–39 years old) from 1990 to 2021.docx by Qingguo Liu (9620123)

“…From 1990 to 2021, the absolute number of stroke-related DALYs attributable to metabolic-risks increased by 22.23%, while the ASDR decreased by 0.78% annually. Regional disparities were evident, with East Asia reporting the largest number of stroke-DALYs attributable to metabolic-risks and Southeast Asia exhibiting the highest ASDR. …”

Focus group guide. by Judite Blanc (22559981)

“…<div><p>Amid the dismantling of state structures in Haiti, the first Black republic faces significant health disparities compared to its former colonial power, France. …”

Table 6_Identification and validation for biomarkers associated with mitochondrial metabolism in chronic obstructive pulmonary disease.xlsx by Wenjun Wang (314231)

“…The mRNA and protein expression of APRT and LCAT were significantly decreased in COPD patients’ lung tissues.…”

Data Sheet 1_In silico molecular studies of Phosphinogold(I) thiocarbohydrate complexes: insights into multi-target anticancer mechanisms.docx by Alkhair Adam Khalil Mohamed (21529289)

“…While acetylation decreased binding affinity; it enhanced cellular activity as reported in in vitro studies indicative of the need to balance lipophilicity and binding strength in future ligand design.…”

Image 4_Global burden of varicella and herpes zoster across 204 countries, 1990–2021: a temporal trend analysis in the era of the COVID-19 pandemic and projections to 2036.tiff by Zilun Wu (18696883)

“…Mortality and DALYs declined significantly, with age-standardized mortality rates (ASMR) and DALYs rates (ASDR) decreasing by 50.0 and 36.3%, respectively. …”

Data Sheet 1_CD19+ B cell depletion: a novel strategy to alleviate ischemic stroke damage.pdf by Yu Xu (52257)

“…Mice subjected to middle cerebral artery occlusion (MCAO) exhibited significant reductions in infarct size and brain edema, prolonged post-MCAO survival, and improved behavioral outcomes following aCD19 Ab treatment. …”

Supplementary file 1_Proof-of-concept of a prior validated LC-MS/MS method for detection of N-lactoyl-phenylalanine in dried blood spots before, during and after a performance diag... by H. Bauhaus (22335913)

“…No statistically significant correlations were identified between lac-phe and lactate, glucose as well as anthropometric and respiratory parameters.…”

Table_1_Oxidative stress and inflammation mediate the association between elevated oxidative balance scores and improved sleep quality: evidence from NHANES.docx by Qu Zhang (486455)

“…Sensitivity analyses revealed a significant association between OBS and sleep disorder (p < 0.001).…”

Image 2_A unique polygenic mouse model of obesity exhibits a distinct immunological profile that may offer protection against systemic inflammation, diabetes, and behavioral impair... by Ulrike Gimsa (9730208)

“…Unlike other mouse lines, DU6 mice do not develop diabetes despite significant obesity. We performed a series of behavioral tests on male mice because obesity is often associated with cognitive and emotional impairment. …”

Table 1_Long-term multicomponent exercise enhances functional mobility in early-stage Parkinson’s disease: a 48-month retrospective cohort study.docx by Marcos Moura (22671914)

“…</p>Results<p>After 48 months, TUG time decreased by −3.8 s (95% CI: −5.0 to −2.6; p < 0.001; dz = −1.12) and 6MWT distance increased by +88.8 m (95% CI: 45.1 to 133.0; p < 0.001; dz = 0.72), both exceeding MDC thresholds. …”

Figure 3 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRP... by Makito Mizunuma (18950775)

“…The left shifts of the peaks seen in the sensitive cell lines indicate decreased mitochondrial membrane potential. Carbonyl cyanide-<i>p</i>-trifluoromethoxyphenylhydrazone, an uncoupler of oxidative phosphorylation, was used as the positive control. …”

<b>Mass, Residency Duration, and Previous Experience Shape Post-Escalation but Not Pre-Escalation Outcomes in Experimental Territorial Contests of Atlantic Mudskippers (</b><b><i>P... by Michael Smith (21714377)

“…Recent contest experience had significant, role-specific effects only in the post-escalation phase: stronger winner and loser effects in intruders, and a weaker winner effect in residents. …”

Data Sheet 1_EURAD state-of-the-art report: thermo-hydro-mechanical behaviour of clay buffers at high temperatures.pdf by María Victoria Villar (20955281)

“…The clay mineralogy was significantly preserved. The slight changes observed in the other properties were opposite depending on the heating conditions: in the case of evaporation, the cation exchange capacity, specific surface area, sorption coefficients, and sometimes swelling pressure decreased. …”

Data Sheet 1_The role of oxidative stress in modulating mortality risk across the hypertension control cascade.docx by Weihao Liu (4472227)

“…Q1, HR: 0.82; 95% CI: 0.66–0.87; P < 0.001). A significant interaction was observed between OBS and hypertension control status (P for interaction = 0.017 and 0.026), corroborated by sensitivity analyses (P for interaction = 0.025). …”

Data Sheet 4_CD44 knockdown alters miRNA expression and their target genes in colon cancer.pdf by Diana Maltseva (11678641)

“…Introduction<p>Metastasis formation poses a significant challenge to oncologists, as it severely limits the survival of colorectal cancer (CRC) patients. …”

Table 2_The global burden of pediatric infective endocarditis (5–14 years): epidemiological patterns from 1990 to 2021 and projected trajectories.pdf by Ying Xiao (6517)

“…</p>Conclusions<p>While significant progress has been made in reducing the global burden of pediatric IE, major geographic and socio-demographic inequalities persist. …”

Data Sheet 1_From court to community: a cost–benefit evaluation of a community sports programme for Arab women in Israel's multiethnic context.docx by Limor Dina Gonen (14258380)

“…Gains in mental well-being were observed but did not reach statistical significance (p = 0.09). Modest increases were found in social capital and community engagement. …”