Image 1_MFN2-a multifaceted guardian against Parkinson’s pathophysiology: mitochondria, ferroptosis, inflammation and oxidative stress.tif by Yan Cheng (149222)

“…</p>Conclusion<p>MFN2 may play a protective role in PD by regulating mitochondrial function, ferroptosis, inflammation and oxidative stress-related factors, providing a new theoretical basis and potential therapeutic targets for the treatment of PD.…”

Data Sheet 1_Tofacitinib extends survival in a mouse model of ALS through NK cell-independent mechanisms.docx by Lillia A. Baird (10575941)

“…Background<p>Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease with few treatment options, rendering the development of new, effective therapeutics of critical importance. …”

DataSheet1_Treatment and molecular analysis of bullous pemphigoid with tofacitinib: a case report and review of current literature.docx by Xiang Li (114679)

“…Glucocorticosteroids are the main therapeutic agents for it, but their efficacy is poor in some patients. Tofacitinib, a small molecule agent that inhibits JAK1/3, has shown incredible efficacy in a wide range of autoimmune diseases and maybe a new valuable treatment option for refractory BP.…”

DataSheet2_Treatment and molecular analysis of bullous pemphigoid with tofacitinib: a case report and review of current literature.xlsx by Xiang Li (114679)

“…Glucocorticosteroids are the main therapeutic agents for it, but their efficacy is poor in some patients. Tofacitinib, a small molecule agent that inhibits JAK1/3, has shown incredible efficacy in a wide range of autoimmune diseases and maybe a new valuable treatment option for refractory BP.…”

Table_1_Outcomes of retroperitoneal fibrosis-related hydronephrosis and its risk factors for poor prognosis: a multi-center retrospective cohort study in Chinese patients.DOCX by figshare admin frontiersin (4545187)

“…Glucocorticoid-based therapy could reduce the time of stenting, decrease the need for long-term ureteral stenting/percutaneous nephrostomy (PNS)/ureterolysis, increase the rate of mass shrinkage, and reduce the new requirement of hemodialysis compared to surgery-only strategy for RPF-related hydronephrosis patients in need of renal drainage, but did not reduce new-onset renal atrophy.…”

Data Sheet 1_Efficacy and safety of pseudolaric acid B against Echinococcus multilocularis in vitro and in a murine infection model.pdf by Zhuo-ma Dawa (20632718)

“…</p>Conclusion<p>PAB has a significant killing effect on E. multilocularis, suggesting that it is a potential candidate for the treatment of AE.…”

Data Sheet 1_Effects of plant extracts on patients with heart failure: a network meta-analysis of randomized controlled trials.pdf by Jieyin Deng (22563188)

“…Ethnopharmacological relevance<p>Heart failure (HF) is a major global health challenge. Traditional therapies have limitations, while recent studies highlight plant extracts’ potential due to their medicinal properties and milder side effects.…”

Table2_Causal relationship between plasma lipidome and four types of pancreatitis: a bidirectional Mendelian randomization study.xlsx by Runzhou Ma (19758996)

“…Furthermore, genetically predicted increased LPC (20:4) (OR = 0.862, 95%CI = 0.796-0.934, P = 3.00 × 10^-4, PFDR = 0.027) and SM (34:2;O2) (OR = 0.753, 95%CI = 0.659-0.860, P = 2.97 × 10^-5, PFDR = 0.005) levels were associated with decreased risk of ACP.</p>Conclusions<p>Our findings provide evidence of causal associations between the specific types of lipidome and pancreatitis, offering new insights into future clinical research.…”

Table4_Causal relationship between plasma lipidome and four types of pancreatitis: a bidirectional Mendelian randomization study.xlsx by Runzhou Ma (19758996)

“…Furthermore, genetically predicted increased LPC (20:4) (OR = 0.862, 95%CI = 0.796-0.934, P = 3.00 × 10^-4, PFDR = 0.027) and SM (34:2;O2) (OR = 0.753, 95%CI = 0.659-0.860, P = 2.97 × 10^-5, PFDR = 0.005) levels were associated with decreased risk of ACP.</p>Conclusions<p>Our findings provide evidence of causal associations between the specific types of lipidome and pancreatitis, offering new insights into future clinical research.…”

Table1_Causal relationship between plasma lipidome and four types of pancreatitis: a bidirectional Mendelian randomization study.xlsx by Runzhou Ma (19758996)

“…Furthermore, genetically predicted increased LPC (20:4) (OR = 0.862, 95%CI = 0.796-0.934, P = 3.00 × 10^-4, PFDR = 0.027) and SM (34:2;O2) (OR = 0.753, 95%CI = 0.659-0.860, P = 2.97 × 10^-5, PFDR = 0.005) levels were associated with decreased risk of ACP.</p>Conclusions<p>Our findings provide evidence of causal associations between the specific types of lipidome and pancreatitis, offering new insights into future clinical research.…”

Table5_Causal relationship between plasma lipidome and four types of pancreatitis: a bidirectional Mendelian randomization study.xlsx by Runzhou Ma (19758996)

“…Furthermore, genetically predicted increased LPC (20:4) (OR = 0.862, 95%CI = 0.796-0.934, P = 3.00 × 10^-4, PFDR = 0.027) and SM (34:2;O2) (OR = 0.753, 95%CI = 0.659-0.860, P = 2.97 × 10^-5, PFDR = 0.005) levels were associated with decreased risk of ACP.</p>Conclusions<p>Our findings provide evidence of causal associations between the specific types of lipidome and pancreatitis, offering new insights into future clinical research.…”

Table3_Causal relationship between plasma lipidome and four types of pancreatitis: a bidirectional Mendelian randomization study.xlsx by Runzhou Ma (19758996)

“…Furthermore, genetically predicted increased LPC (20:4) (OR = 0.862, 95%CI = 0.796-0.934, P = 3.00 × 10^-4, PFDR = 0.027) and SM (34:2;O2) (OR = 0.753, 95%CI = 0.659-0.860, P = 2.97 × 10^-5, PFDR = 0.005) levels were associated with decreased risk of ACP.</p>Conclusions<p>Our findings provide evidence of causal associations between the specific types of lipidome and pancreatitis, offering new insights into future clinical research.…”

Data Sheet 1_Global burden of cancer in adolescents and young adults aged 10–24 years: a trend analysis.pdf by Junjun Yang (307892)

Data Sheet 1_Identification of potential biomarkers for lung adenocarcinoma: a study based on bioinformatics analysis combined with validation experiments.zip by Chuchu Zhang (2562154)

“…Among them, only TGFBR2 had a significant causal relationship with LUAD (p=0.04, b=−0.06), and it is a protective factor for LUAD. …”

All data. by Ke Li (106849)

“…Metabolomics analysis revealed that inulin treatment significantly modulated the levels of 8 stage-specific metabolites; notably, it increased anti-inflammatory, anti-diabetic and neuroprotective metabolites taurine and dodecanoic acid in prediabetic mice, while decreasing pro-inflammatory mediators including oleamide and adrenic acid. …”

Data Sheet 1_Hypocomplementemia dynamics during tocilizumab therapy in systemic juvenile idiopathic arthritis: a retrospective longitudinal study.xlsx by Jiayun Ling (15249289)

“…After 2 weeks of TCZ treatment, median (IQR) serum C3 levels declined from 1.45(1.27-1.75) g/L at baseline to 1.11 (0.97-1.18) g/L (a 23.45% reduction, P = 0.009), and C4 levels decreased from 0.29 (0.21-0.38) g/L to 0.13 (0.09-0.17) g/L (a 55.17% reduction, P = 0.005). …”

Table2_The incidence, mortality and disease burden of cardiovascular diseases in China: a comparative study with the United States and Japan based on the GBD 2019 time trend analys... by Menglan Zhu (10268801)

“…Compared with the US and Japan, from 1990 to 2019, the CVDs incidence rate in China showed an increasing trend, with a lower annual decrease in ASDR and a younger age structure of disease burden. …”

Table1_The incidence, mortality and disease burden of cardiovascular diseases in China: a comparative study with the United States and Japan based on the GBD 2019 time trend analys... by Menglan Zhu (10268801)

“…Compared with the US and Japan, from 1990 to 2019, the CVDs incidence rate in China showed an increasing trend, with a lower annual decrease in ASDR and a younger age structure of disease burden. …”

Table3_The incidence, mortality and disease burden of cardiovascular diseases in China: a comparative study with the United States and Japan based on the GBD 2019 time trend analys... by Menglan Zhu (10268801)

“…Compared with the US and Japan, from 1990 to 2019, the CVDs incidence rate in China showed an increasing trend, with a lower annual decrease in ASDR and a younger age structure of disease burden. …”

Data Sheet 3_Media health literacy predicts preventive health behaviors: findings from a nationally matched survey.pdf by Shadee Hall Ashtari (22335568)

“…A single-point increase on the Index was independently associated with increased odds of vaccination, mammography, and annual exam attendance, and decreased odds of smoking and vaping.…”