Supplementary file 1_Case Report: Loss-of-function TRPM4 mutation p.L91Δ implicated in progressive cardiac conduction defect.docx by Anne-Flore Hämmerli (18121647)

“…</p>Conclusion<p>The new TRPM4 in-frame deletion, p.L91Δ, identified in two unrelated patients with a consistent phenotype, causes a significant decrease in channel expression, leading to its loss of function in the heterologous expression system. …”

Updated poaching trends until 2024 for West Coast rock lobster by Anabela Brandao (10003679)

“…In the case of the northern Super-areas (3-7), a statistically significant decrease is evident. …”

Table 1_Association between estimated glucose disposal rate and the risk of atherosclerotic cardiovascular disease: insight from cross-sectional and retrospective cohort studies.do... by Zixuan Wang (35190)

“…Background<p>Accumulating data have elucidated a significant association between insulin resistance (IR) and the risk of cardiovascular diseases. …”

<b>Enhanced plant diversity reduces nitrous oxide emissions in forest soils</b><b> worldwide</b> by Hanling Zuo (19163980)

“…Our analyses reveal that tree diversity has a significant negative effect on soil N₂O emissions, primarily driven by a decrease in N₂O production associated with denitrification. …”

Table 1_Burden of esophageal cancer in global, regional and national regions from 1990 to 2021 and its projection until 2050: results from the GBD study 2021.docx by Chengcheng Zhang (725743)

“…</p>Results<p>In 2021, there were 576,529 new esophageal cancer cases, with an age-standardized incidence rate (ASIR) of 6.65 per 100,000, reflecting a 24.87% decrease since 1990. …”

Caddisfly biodiversity in Pernambuco state, Brazil: overcoming the biodiversity knowledge shortfall and insights into the effects of climate change by Rafael Pereira (6635264)

“…Climate projections indicate a significant decrease in the temperature range, shifting from the current 13.2–33.6 °C to 17.9–33.6 °C, and precipitation range will decrease from 507 to 1948 mm³/year to 528–1428 mm³/year. …”

Chain-length specific phospholipid and diacylglycerol abnormalities in peroxisomal mutant larvae. by Michael F. Wangler (21526595)

Efficacy of Topical Cyclosporine Combined with Punctal Plugs in Treating Dry Eye Disease and Inflammation by Changming Feng (19810956)

“…</p> <p>In combination therapy group of the clinical trial, the following results were observed: significant improvement in Schirmer I test scores and FBUT compared to the cyclosporine group and punctal plug group, respectively; a decrease in the tear levels of IL-6, IL-1, and MMP-9 compared to the punctal plug group; and a decrease in the tear levels of IL-1α, IL-6, and IL-17 compared to the baseline (all <i>p</i> < 0.05). …”

Mapping changes in patterning after inhibition of Notch activity. by Matthew French (13007466)

“…LY conditions and associated <i>p</i>-values per ROI. Note the overall decrease in TBXT and TBX6 gradient steepness, with a new posteriorly located nonlinear TBXT gradient. …”

Image 2_Long-term trends and comparison of the burden of lower respiratory tract infections in China and globally from 1990 to 2021: an analysis based on the Global Burden of Disea... by Zhiwei Wang (120259)

“…Compared with the previous period, the COVID-19 pandemic has led to a significant decrease in the disease burden of LRIs. …”

Table 1_Long-term trends and comparison of the burden of lower respiratory tract infections in China and globally from 1990 to 2021: an analysis based on the Global Burden of Disea... by Zhiwei Wang (120259)

“…Compared with the previous period, the COVID-19 pandemic has led to a significant decrease in the disease burden of LRIs. …”

Image 1_Long-term trends and comparison of the burden of lower respiratory tract infections in China and globally from 1990 to 2021: an analysis based on the Global Burden of Disea... by Zhiwei Wang (120259)

“…Compared with the previous period, the COVID-19 pandemic has led to a significant decrease in the disease burden of LRIs. …”

Table 2_Long-term trends and comparison of the burden of lower respiratory tract infections in China and globally from 1990 to 2021: an analysis based on the Global Burden of Disea... by Zhiwei Wang (120259)

“…Compared with the previous period, the COVID-19 pandemic has led to a significant decrease in the disease burden of LRIs. …”

Image 1_Alpha 1-antitrypsin mitigates salt-sensitive hypertension in juvenile mice by reducing diacylglycerol concentrations and protein kinase C activity in kidney membranes.tif by Yunus E. Dogan (19859574)

“…</p>Conclusion<p>Taken together, this study demonstrates a new protective effect of hAAT in normalizing blood pressure after the development of saltinduced hypertension in juvenile mice in a mechanism involving a decrease in NKCC2 membrane expression, presumably due to decreased levels of DAGs in the plasma membrane and a subsequent decrease in PKC activity.…”

Table 1_Alpha 1-antitrypsin mitigates salt-sensitive hypertension in juvenile mice by reducing diacylglycerol concentrations and protein kinase C activity in kidney membranes.docx by Yunus E. Dogan (19859574)

“…</p>Conclusion<p>Taken together, this study demonstrates a new protective effect of hAAT in normalizing blood pressure after the development of saltinduced hypertension in juvenile mice in a mechanism involving a decrease in NKCC2 membrane expression, presumably due to decreased levels of DAGs in the plasma membrane and a subsequent decrease in PKC activity.…”

Tropical volcanic eruptions enhance global tropical cyclone geneses by Jiuwei Zhao (8548263)

“…We find a significant increase in TCGF over the </b><b>Pacific within two years following strong TVEs, accompanied by an insignificant decrease </b><b>over the South Indian Ocean, leading to a net global TCGF increase. …”

Data Sheet 1_Genomic and immune profiling of prognostic risk groups in IgM gammopathy reveals novel biomarkers beyond MYD88 L265P.docx by David F. Moreno (5597948)

“…</p>Results<p>We observed that low-risk patients were only characterized by the presence of MYD88 L265P, while intermediate- and high-risk groups harbored additional mutations on CXCR4, KMT2D, ARID1A and EP300. Regarding the mRNA expression analyses, we found an increased proportion of myeloid cells in the low-risk group, with monocytes having a significant decrease in low versus high-risk patients. …”

Data Sheet 1_Public perception of COVID-19 in Saudi Arabia during the Omicron wave: recommendations for policy improvement.pdf by Mohammed J. Almalki (11808158)

“…Conversely, when asked about the primary reasons for expecting a decrease in COVID-19 cases, participants cited the availability of free vaccines (60.3%), government measures (59.9%), compliance with preventive measures (57.4%), and health awareness programs (44.1%). …”

Image 1_Alpha oscillatory dysregulation: mapping EEG oscillatory in suicidal depression.tiff by Yue Zhao (186573)

“…</p>Results<p>EEG analysis showed a significant increase in alpha-band PSD and a significant decrease in FAA in DSI compared to DNSI (p < 0.05). …”

Table 1_Alpha oscillatory dysregulation: mapping EEG oscillatory in suicidal depression.docx by Yue Zhao (186573)

“…</p>Results<p>EEG analysis showed a significant increase in alpha-band PSD and a significant decrease in FAA in DSI compared to DNSI (p < 0.05). …”