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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
new decrease » nn decrease (Expand Search), mean decrease (Expand Search), teer decrease (Expand Search)
we decrease » _ decrease (Expand Search), a decrease (Expand Search), nn decrease (Expand Search)
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561
Data Sheet 1_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.docx
Published 2025“…Introduction<p>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. Despite significant progress in systemic and immune-based therapies, many patients develop resistance or fail to respond, highlighting the need for new molecular targets. …”
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562
Video 3_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4
Published 2025“…Introduction<p>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. Despite significant progress in systemic and immune-based therapies, many patients develop resistance or fail to respond, highlighting the need for new molecular targets. …”
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563
Video 7_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4
Published 2025“…Introduction<p>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. Despite significant progress in systemic and immune-based therapies, many patients develop resistance or fail to respond, highlighting the need for new molecular targets. …”
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564
Glycogen synthase kinase 3 promotes the proliferation of porcine epidemic diarrhea virus by phosphorylating the nucleocapsid protein
Published 2025“…The phosphorylation level significantly decreased after mutation of threonine (Thr) to serine (Ser). …”
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565
Table_1_Major air pollution and climate policies in NYC and trends in NYC air quality 1998–2021.docx
Published 2024“…We used previously available data from citywide monitoring and new data from the Columbia Center for Children’s Environmental Health (CCCEH) longitudinal cohort studies of mothers and children living in communities in Northern Manhattan and the South Bronx.…”
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566
<b>Tracking incidence classification changes across disturbances at Konza Prairie LTER</b>
Published 2025“…We predict that grazing, as a press disturbance, will result in a higher proportion of species classified as directed change - increasing or decreasing. …”
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567
Glycogen synthase kinase 3 promotes the proliferation of porcine epidemic diarrhoea virus by phosphorylating the nucleocapsid protein
Published 2025“…The phosphorylation level significantly decreased after mutation of threonine (Thr) to serine (Ser). …”
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568
The evolution of inharmonicity and noisiness in contemporary popular music
Published 2025“…We introduce new features that distinguish between inharmonicity caused by noise and that resulting from interactions between discrete partials. …”
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569
Table 1_The impact of comorbidities on surgical outcome and mortality in minimally invasive mitral valve surgery: a systematic review.docx
Published 2025“…Left atrial (LA) diameter decreased significantly from 50.37 mm preoperatively to 40.41%mm postoperatively (p < 0.001), LVDD was significantly reduced after MIMVS (p < 0.001). …”
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570
Changes in functional connectivity between NREM and REM – comparison of in vivo experimental and in silico modeling data.
Published 2025“…<p>A) Schematic of analyzed experiments. (TOP, CFC) We analyzed 6h of recorded baseline when mouse is placed in home cage. …”
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571
Table 1_TCF3 downregulation alleviates renal fibrosis via PI3K/Akt/mTOR pathway inhibition and autophagy restoration in diabetic nephropathy.docx
Published 2025“…Both the DN rat model and HG-stimulated HK-2 cells exhibited enhanced EMT markers, with significantly increased α-SMA and vimentin expression (p < 0.001), and decreased E-cadherin levels (p < 0.001). …”
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572
Supplementary Material for: The effectiveness of regionalization of perinatal care and specific facility-based interventions: A systematic review
Published 2024“…Results: Implementation of regionalization programs significantly decreased maternal and perinatal mortality. …”
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573
Supplementary Material for: Identifying novel inflammatory protein biomarkers and drug targets of inflammatory bowel disease by integrating Mendelian randomization, bioinformatics,...
Published 2025“…Conclusions: Our results provide new biomarkers and drug targets for CD. Moreover, we further demonstrate critical roles of inflammation and immunity in the occurrence and development of IBD.…”
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574
Data Sheet 1_Combination of MLo-1508 with sunitinib for the experimental treatment of papillary renal cell carcinoma.docx
Published 2025“…Finally, the combinatory potential of MLo-1508 and sunitinib were asses both in vitro and in vivo using the ACHN cell line. We found that MLo-1508 significantly decreased RCC cell viability while inducing apoptosis in a dose-dependent manner without cytotoxicity for non-malignant cells. …”
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575
Raw data for main and supplemental figures
Published 2025“…We found that deletion of <i>proQ</i> significantly enhanced cell adherence ability of EHEC and led to upregulation of the locus of enterocyte effacement (LEE) pathogenicity island. …”
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576
Table 1_Inflammatory biomarkers and therapeutic potential of milk exosome-mediated CCL7 siRNA in murine intestinal ischemia-reperfusion injury.docx
Published 2025“…</p>Methods<p>Using transcriptome sequencing in a mouse model of IIRI, we identified potential biomarkers that were significantly upregulated in the IIRI group compared to the sham group. …”
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577
Data Sheet 1_Single-cell transcriptomics reveals predominantly inflammatory endothelial cell responses and suppressed vascular repair in silicosis.pdf
Published 2025“…</p>Results<p>We identified two functionally distinct endothelial subpopulations: 1. …”
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578
Data Sheet 2_Single-cell transcriptomics reveals predominantly inflammatory endothelial cell responses and suppressed vascular repair in silicosis.pdf
Published 2025“…</p>Results<p>We identified two functionally distinct endothelial subpopulations: 1. …”
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579
Table 1_Single-cell transcriptomics reveals predominantly inflammatory endothelial cell responses and suppressed vascular repair in silicosis.docx
Published 2025“…</p>Results<p>We identified two functionally distinct endothelial subpopulations: 1. …”
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580
Image 1_Cordyceps militaris solid medium extract alleviates lipopolysaccharide-induced acute lung injury via regulating gut microbiota and metabolism.tif
Published 2025“…The 16S rRNA results revealed that CMME significantly increased gut microbiota richness and diversity and reduced the abundance of Bacteroides compared with Mod group significantly. …”