Image 1_Human beta defensin-2 protects the epithelial barrier during methicillin-resistant Staphylococcus aureus infection in chronic rhinosinusitis with nasal polyps.tif by Tengfei Tian (1793545)

“…The presence of hBD-2 significantly reduced the invasive ability of MRSA in HNECs. …”

Data Sheet 1_α-methyltryptophan-mediated protection against diabetic nephropathy in db/db mice as studied with a metabolomics approach.docx by Aimin Cai (6190532)

“…</p>Results<p>The results of the study demonstrated that α-MT significantly reduced the urinary excretion of albumin and creatinine, improved kidney function, and decreased renal fibrosis in db/db mice. …”

Image 2_Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) le... by Ting Yang (189879)

“…Furthermore, 29 out of 47 differential metabolites significantly correlated with the eight dominant microbial genera. …”

Image 2_3KO-NSCs ameliorate behavioral deficits and modulate gut microbiota in a VPA-induced C57BL/6 mouse model of autism.tif by Caixia Wu (8959697)

“…</p>Results<p>3KO-hiPSC-NSC treatment significantly ameliorated VPA-induced ASD-like behaviors. …”

Design, synthesis and biological evaluation of marine naphthoquinone-naphthol derivatives as potential anticancer agents by Yujuan Li (554062)

“…Further mechanistic studies revealed that compound <b>13</b> significantly induced cell apoptosis by increasing the expression levels of cleaved caspase-3 and reducing Bcl-2 proteins through downregulating the EGFR/PI3K/Akt signalling pathway, leading to the inhibition of proliferation in HCT116 and PC9 cells. …”

Supplementary Material for: A common variant in NID1 gene associated with the prognosis of heart failure by figshare admin karger (2628495)

“…Western blot analysis demonstrated that the protein level of NID1 was significantly higher in the rs3738530-T allele compared to the A allele (P < 0.05). …”

Data Sheet 12_Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective.pdf by Didar Murad (12220805)

“…We explored that the decreased levels of complement factor H and C1-inhibitor significantly elevate these components, whereas tissue factor pathway inhibitor and alpha-2-macroglobulin have more modest effects. …”

Image 14_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.jpeg by Chen Wang (88408)

“…In vivo, RBM15 depletion significantly delayed tumor progression and enhanced CD8⁺ T cell infiltration and activation in the tumor microenvironment.…”

Dust particle flow trace diagram. by Yuxuan Liu (349237)

“…Results indicate that installing a return pipe significantly reduces dust overflow caused by impact airflow during blanking. …”

Adverse events in patients with castration-resistant prostate cancer treated with ra-223: a retrospective pharmacovigilance study by Lei Yang (102719)

“…Four sequential analysis strategies were employed to assess the significance of these AEs.</p> <p>In total, 4,228 Ra-223-related AE reports were identified in the FAERS database. …”

Table 1_Integrative multi-omics analysis and experimental validation identify molecular subtypes, prognostic signature, and CA9 as a therapeutic target in oral squamous cell carcin... by Yun Zhao (48978)

“…In vitro experiments validated CA9 as a promising therapeutic target, with its knockdown significantly inhibiting OSCC cell proliferation and migration.…”

Model inputs. by Mingxi Xie (19812594)

“…Clinical findings have showed that deprescribing service significantly decreased inappropriate PPIs utilization. …”

Vitreous Olink Proteomics Uncovers Novel Inflammatory Proteins in Patients with Proliferative Diabetic Retinopathy by Jiayu Zhang (128702)

“…Functional studies demonstrated that the conditioned medium from HG-exposed MG significantly enhanced endothelial cell proliferation, migration, and tube formation. …”

Image 5_Comparative genomics and metabolomics reveal phytohormone production, nutrient acquisition, and osmotic stress tolerance in Azotobacter chroococcum W5.tif by M. Elakkya (21760439)

“…Wheat seed inoculation significantly enhanced germination metrics, seedling vigor, and altered carbohydrate metabolism in the seed endosperm. …”

Discrete phase parameter setting. by Yuxuan Liu (349237)

“…Results indicate that installing a return pipe significantly reduces dust overflow caused by impact airflow during blanking. …”

Data Sheet 3_Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective.csv by Didar Murad (12220805)

“…We explored that the decreased levels of complement factor H and C1-inhibitor significantly elevate these components, whereas tissue factor pathway inhibitor and alpha-2-macroglobulin have more modest effects. …”

Table 1_Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) le... by Ting Yang (189879)

“…Furthermore, 29 out of 47 differential metabolites significantly correlated with the eight dominant microbial genera. …”

Table 1_Case report: Treatment of severe phorate poisoning.xlsx by Wang Kunlun (21287522)

“…In the follow-up treatment, the concentration of five metabolites gradually decreased. The concentration of the phorate sulfoxide and phorate sulfone rebounded with the suspension of HP, but that of the other metabolites did not rebound. …”

Bgh/GelMA/CMCS hydrogel with bone MSC-EVs for lunate defect repair by Miaozhong Li (21626739)

“…In vivo, the M1/M2 ratio and inflammatory factors decreased significantly one-week post-implantation, while CD31 and VEGF-positive cells increased at four weeks, and BMP2 and OPN-positive cells at eight weeks. …”

Supplementary file 1_Metabolic insights into hypoxia adaptation in adolescent athletes at different altitudes: a cross-sectional study.docx by Carlos A. R. Sánchez (21288050)

“…Lipid metabolism was significantly altered in moderate-altitude athletes, including pathways such as linolenic and linoleic acid, sphingolipid, and arachidonic acid, as well as processes involving the transfer of acetyl groups into mitochondria and fatty acid biosynthesis. …”