IRE1 depletion downregulates multiple cell cycle proteins in synchronized cells. by Iratxe Zuazo-Gaztelu (21071939)

<i>Ctsz</i>^{<i>−/−</i>} mice have higher lung burden and earlier spleen dissemination during acute infection followed by greater chronic inflammation and mortality risk.... by Rachel K. Meade (22216529)

Growth of certain cancer cell lines requires IRE1 but not its enzymatic activity. by Iratxe Zuazo-Gaztelu (21071939)

IRE1 depletion downregulates multiple cell cycle proteins in synchronized cells. by Iratxe Zuazo-Gaztelu (21071939)

IRE1 depletion induces cell cycle arrest independently of apoptosis. by Iratxe Zuazo-Gaztelu (21071939)

Growth of certain cancer cell lines requires IRE1 but not its enzymatic activity. by Iratxe Zuazo-Gaztelu (21071939)

IRE1 silencing downregulates cell cycle genes and engages TP53 and specific CDK inhibitors. by Iratxe Zuazo-Gaztelu (21071939)

IRE1 silencing downregulates cell cycle genes and engages TP53 and specific CDK inhibitors. by Iratxe Zuazo-Gaztelu (21071939)

Scheme of the test section. by Decang Lou (21439960)

“…The results reveal that the large deviation in the manufactured vane (up to 0.5 mm at the leading edge) alters the direction of the coolant flowing out from the leading-edge film-cooling holes, affects the film coverage along the surface, and in consequence, causes the temperature near the stagnation point increasing by approximately 40 K. Furthermore, variations in coolant inlet pressure, decreasing by 10 kPa, and temperature, increasing by 10 K, result in the vane surface temperature increased by 20 ~ 30 K. …”

Effects on cooling air mass flow rate. by Decang Lou (21439960)

“…The results reveal that the large deviation in the manufactured vane (up to 0.5 mm at the leading edge) alters the direction of the coolant flowing out from the leading-edge film-cooling holes, affects the film coverage along the surface, and in consequence, causes the temperature near the stagnation point increasing by approximately 40 K. Furthermore, variations in coolant inlet pressure, decreasing by 10 kPa, and temperature, increasing by 10 K, result in the vane surface temperature increased by 20 ~ 30 K. …”

3D model and section view of E3 NGV. by Decang Lou (21439960)

“…The results reveal that the large deviation in the manufactured vane (up to 0.5 mm at the leading edge) alters the direction of the coolant flowing out from the leading-edge film-cooling holes, affects the film coverage along the surface, and in consequence, causes the temperature near the stagnation point increasing by approximately 40 K. Furthermore, variations in coolant inlet pressure, decreasing by 10 kPa, and temperature, increasing by 10 K, result in the vane surface temperature increased by 20 ~ 30 K. …”

Conditions for uncertainty analyses. by Decang Lou (21439960)

“…The results reveal that the large deviation in the manufactured vane (up to 0.5 mm at the leading edge) alters the direction of the coolant flowing out from the leading-edge film-cooling holes, affects the film coverage along the surface, and in consequence, causes the temperature near the stagnation point increasing by approximately 40 K. Furthermore, variations in coolant inlet pressure, decreasing by 10 kPa, and temperature, increasing by 10 K, result in the vane surface temperature increased by 20 ~ 30 K. …”

Scheme for mesh convergence study. by Decang Lou (21439960)

“…The results reveal that the large deviation in the manufactured vane (up to 0.5 mm at the leading edge) alters the direction of the coolant flowing out from the leading-edge film-cooling holes, affects the film coverage along the surface, and in consequence, causes the temperature near the stagnation point increasing by approximately 40 K. Furthermore, variations in coolant inlet pressure, decreasing by 10 kPa, and temperature, increasing by 10 K, result in the vane surface temperature increased by 20 ~ 30 K. …”

Main test parameters. by Decang Lou (21439960)

“…The results reveal that the large deviation in the manufactured vane (up to 0.5 mm at the leading edge) alters the direction of the coolant flowing out from the leading-edge film-cooling holes, affects the film coverage along the surface, and in consequence, causes the temperature near the stagnation point increasing by approximately 40 K. Furthermore, variations in coolant inlet pressure, decreasing by 10 kPa, and temperature, increasing by 10 K, result in the vane surface temperature increased by 20 ~ 30 K. …”

3-D printed NGV specimen. by Decang Lou (21439960)

“…The results reveal that the large deviation in the manufactured vane (up to 0.5 mm at the leading edge) alters the direction of the coolant flowing out from the leading-edge film-cooling holes, affects the film coverage along the surface, and in consequence, causes the temperature near the stagnation point increasing by approximately 40 K. Furthermore, variations in coolant inlet pressure, decreasing by 10 kPa, and temperature, increasing by 10 K, result in the vane surface temperature increased by 20 ~ 30 K. …”

Relative error bar of surface temperature. by Decang Lou (21439960)

“…The results reveal that the large deviation in the manufactured vane (up to 0.5 mm at the leading edge) alters the direction of the coolant flowing out from the leading-edge film-cooling holes, affects the film coverage along the surface, and in consequence, causes the temperature near the stagnation point increasing by approximately 40 K. Furthermore, variations in coolant inlet pressure, decreasing by 10 kPa, and temperature, increasing by 10 K, result in the vane surface temperature increased by 20 ~ 30 K. …”

Effect on the NGV leading edge temperature. by Decang Lou (21439960)

“…The results reveal that the large deviation in the manufactured vane (up to 0.5 mm at the leading edge) alters the direction of the coolant flowing out from the leading-edge film-cooling holes, affects the film coverage along the surface, and in consequence, causes the temperature near the stagnation point increasing by approximately 40 K. Furthermore, variations in coolant inlet pressure, decreasing by 10 kPa, and temperature, increasing by 10 K, result in the vane surface temperature increased by 20 ~ 30 K. …”

Schematic of the test equipment. by Decang Lou (21439960)

“…The results reveal that the large deviation in the manufactured vane (up to 0.5 mm at the leading edge) alters the direction of the coolant flowing out from the leading-edge film-cooling holes, affects the film coverage along the surface, and in consequence, causes the temperature near the stagnation point increasing by approximately 40 K. Furthermore, variations in coolant inlet pressure, decreasing by 10 kPa, and temperature, increasing by 10 K, result in the vane surface temperature increased by 20 ~ 30 K. …”

Podocyte numbers in control and iPLA₂γ KO mice (WT1-positive cells). by Andrey V. Cybulsky (4007012)

Bidimensional High-Low Frequency (HF, LF) plane representation of the interaction among Phase and High-Low Clarity Groups_: In the Low Clarity (LC) group there was a larg... by David Vagni (8060432)