Calycosin Inhibit PANoptosis and Alleviate Brain Damage: A Bioinformatics and Experimental Verification Approach حسب Huiyan An (20959966)

"…Calycosin, a natural product with diverse biological activities, has demonstrated a significant reduction in neuronal death caused by ischemic brain injury by modulating multiple cell death pathways. …"

Interventions for Psychological Stress in Pregnant African American Women: A Scoping Review حسب Taleah A. Frazier (22423294)

"…<p>Cardiovascular conditions are the leading cause of pregnancy-related death among African American women (AAW). …"

Blood Pressure and LDL-C During Follow-up. حسب Karl Ingard (22582091)

"…The risk of cardiovascular death was significantly decreased (HR 0.64, 95% CI 0.41–0.998, <i>P</i> = 0.049) and the risk of fracture non-significantly increased (HR 1.47, 95% CI 0.95–2.27, <i>P</i> = 0.08) in the intervention group compared to the control group.…"

Baseline Characteristics of Included Patients. حسب Karl Ingard (22582091)

"…The risk of cardiovascular death was significantly decreased (HR 0.64, 95% CI 0.41–0.998, <i>P</i> = 0.049) and the risk of fracture non-significantly increased (HR 1.47, 95% CI 0.95–2.27, <i>P</i> = 0.08) in the intervention group compared to the control group.…"

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement حسب Juraj Velcicky (2201350)

"…This replacement required a shift of the hydrogen bond donor from the “<i>ortho</i>” to the “<i>meta</i>” position, relative to the pyridazine ring. Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. …"

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement حسب Juraj Velcicky (2201350)

"…This replacement required a shift of the hydrogen bond donor from the “<i>ortho</i>” to the “<i>meta</i>” position, relative to the pyridazine ring. Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. …"

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement حسب Juraj Velcicky (2201350)

"…This replacement required a shift of the hydrogen bond donor from the “<i>ortho</i>” to the “<i>meta</i>” position, relative to the pyridazine ring. Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. …"

Patient status overview. حسب Farayi Kaseke (19560197)

"…Those who had attained a secondary school level education displayed a significantly lower risk of death (aHR: 0.4, 95% CI: 0.24, 0.79) compared to those with primary level education. …"

Histogram of the extracted parameters. حسب Qiuyu Du (20760848)

"…Logistic regression (n = 93) showed that a less steep contrast gradient (decreasing by 10 Hounsfield unit/%) was associated with a reduction in odds of the following short-term adverse outcomes: 48.1% for intensive care unit admission (odds ratio [OR] = 0.519, 95% confidence interval [CI]: 0.306–0.804), 29.3% for oxygen therapy >24 hours (OR = 0.707, 95% CI: 0.496–0.976), 60.6% for reperfusion therapy (OR = 0.394, 95% CI: 0.178–0.682), 57.5% for vasopressor therapy (OR = 0.425, 95% CI: 0.194–0.741), and 50.2% for PE-related death (OR = 0.498, 95% CI: 0.246–0.915). …"

Data Sheet 1_The global, regional, and national impact of laryngeal cancer from 1990 to 2021, along with forecasts for 2050: a comprehensive analysis for the Global Burden of Disea... حسب Tingting Duan (5181482)

"…</p>Methods<p>Using data from the GBD 2021, we investigated the incidence, prevalence, deaths, and Disability-Adjusted Life Years (DALYs) of LC, as well as trends, age-sex-time patterns, driving factors, and projections up to 2050.…"

Data Sheet 1_In vivo and in vitro therapeutic evaluation of bone marrow-derived mesenchymal stem cells in liver cancer treatment.pdf حسب Abdulrahman Johor (21265181)

"…<p>Hepatocellular carcinoma is the seventh most common kind of cancer worldwide and the second largest cause of cancer-related deaths in males, behind lung cancer. Globally, 866,000 people were diagnosed with hepatocellular carcinoma (HCC) in 2022, and nearly 42,240 new cases will be identified in 2025 in the United States. …"

Table 1_Global, regional, and national esophageal cancer deaths and DALYs attributable to diet low in vegetables and fruits, 1990–2019: analysis for the global burden of disease st... حسب Bing Cui (179696)

"…The disease burden attributable to insufficient fruit intake (51,210 deaths, 12,497,75 DALYs) was significantly higher than that from inadequate vegetable intake (17,176 deaths, 4,203,09 DALYs). …"

Table 1_Global, regional, and national burden of myocarditis and its attributable risk factors in 204 countries and territories from 1990 to 2021: updated systematic analysis.docx حسب Jiajia Ren (11151738)

"…And non-optimal temperatures, defined as same-day exposure to ambient temperatures deviating from the minimum death risk threshold, were identified as risk-factors for myocarditis-related death and DALYs.…"

Key Resources. حسب Jeffrey Chin (22538086)

"…These experiments revealed that Tax1bp1 protein abundance does not significantly change early after infection in AMs but does in BMDMs; moreover, early after infection, Tax1bp1-deficiency reduced necrotic-like cell death -- an outcome that favors <i>Mtb</i> replication -- in AMs but not BMDMs. …"

Tax1bp1-deficiency reduces autophagy flux. حسب Jeffrey Chin (22538086)

"…These experiments revealed that Tax1bp1 protein abundance does not significantly change early after infection in AMs but does in BMDMs; moreover, early after infection, Tax1bp1-deficiency reduced necrotic-like cell death -- an outcome that favors <i>Mtb</i> replication -- in AMs but not BMDMs. …"

Table1_Tle6 deficiency in male mice led to abnormal sperm morphology and reduced sperm motility.docx حسب Kousuke Kazama (19937214)

DataSheet1_Glioma-associated oncogene homolog 1 in breast invasive carcinoma: a comprehensive bioinformatic analysis and experimental validation.docx حسب Teng Qi (278739)

"…Background<p>Breast cancer, despite significant advancements in treatment, remains a major cause of cancer-related deaths among women. …"

Data Sheet 1_PANoptosis-related gene clusters and prognostic risk model in clear cell renal cell carcinoma.docx حسب Qiyue Zhao (12721537)

"…</p>Methods<p>We conducted a bioinformatics analysis of the expression PANoptosis-related genes (PRGs) in 524 ccRCC patients from the TCGA and GEO databases. …"

Table1_Myocardial infarction in rats was alleviated by MSCs derived from the maternal segment of the human umbilical cord.DOCX حسب Shuifen Sun (19855329)

Table2_Cuproptosis-related lncRNAs emerge as a novel signature for predicting prognosis in prostate carcinoma and functional experimental validation.docx حسب Yangbai- Lu (19955883)

"…Cuproptosis, a newly discovered form of cell death. The relationship between cuproptosis-related long non-coding RNAs (ClncRNAs) related to PCa and prognosis remains unclear. …"