Supplementary file 1_Burden of ageing spectrum of diseases in China, 1990–2021: a systematic analysis of global burden of disease study 2021.pdf حسب Li Yang (6520)

"…</p>Results<p>From 1990 to 2021, The ASR of all-cause DALYs in China decreased by 35.94% overall and by 33.99% among individuals ≥65 years. …"

Table 1_WTAP modulates macrophage polarization in rheumatoid arthritis by targeting exosomal circ-CBLB via m6A modification.docx حسب Dawei Yan (193244)

"…Functional experiments demonstrated that WTAP overexpression decreased exosomal circ-CBLB levels and promoted macrophage polarization toward the pro-inflammatory M1 phenotype, which was reversed by m⁶A modification site mutation.…"

DataSheet1_Lipocalin-2 drives neuropsychiatric and cutaneous disease in MRL/lpr mice.docx حسب Sayra J. Garcia (19748644)

"…</p>Results<p>In this study, we found that LCN2 deficiency significantly attenuates neuropsychiatric and cutaneous disease in MRL/lpr lupus prone mice, likely by decreasing local infiltration of immune cells into the brain and skin and reducing astrocyte activation in the hippocampus. …"

Table 1_Behavioral alterations in antibiotic-treated mice associated with gut microbiota dysbiosis: insights from 16S rRNA and metabolomics.xlsx حسب Asma Bibi (12057986)

"…The KEGG enrichment analysis of serum and brain samples showed that amino acid metabolism pathways, such as tryptophan metabolism, threonine metabolism, serotonergic synapsis, methionine metabolism, and neuroactive ligand-receptor interaction, were significantly decreased in antibiotic-treated mice. Our study demonstrates that long-term antibiotic use induces gut dysbiosis and alters metabolic responses, leading to the dysregulation of brain signaling molecules and anxiety-like behavior. …"

Image 2_Behavioral alterations in antibiotic-treated mice associated with gut microbiota dysbiosis: insights from 16S rRNA and metabolomics.tif حسب Asma Bibi (12057986)

"…The KEGG enrichment analysis of serum and brain samples showed that amino acid metabolism pathways, such as tryptophan metabolism, threonine metabolism, serotonergic synapsis, methionine metabolism, and neuroactive ligand-receptor interaction, were significantly decreased in antibiotic-treated mice. Our study demonstrates that long-term antibiotic use induces gut dysbiosis and alters metabolic responses, leading to the dysregulation of brain signaling molecules and anxiety-like behavior. …"

Table 1_Supplementation of Yupingfeng polysaccharides in low fishmeal diets enhances intestinal health through influencing the intestinal barrier, immunity, and microflora in Macro... حسب Mingyang Liu (426690)

"…</p>Results<p>The LF diet significantly reduced growth performance parameters compared to the control group. …"

Data Sheet 1_Dendritic cells in the human vaginal mucosa can direct CD4+ T cell responses by expressing surface OX40L.pdf حسب HyeMee Joo (175770)

"…Neutralizing OX40L with anti-OX40L antibody significantly decreased the frequency of Th2-type CD4⁺ T cells with a reduction of CD4⁺ T cell proliferation, while increasing the frequency of IL - 10-producing CD4⁺ T cell responses. …"

Data Sheet 2_Dendritic cells in the human vaginal mucosa can direct CD4+ T cell responses by expressing surface OX40L.pdf حسب HyeMee Joo (175770)

"…Neutralizing OX40L with anti-OX40L antibody significantly decreased the frequency of Th2-type CD4⁺ T cells with a reduction of CD4⁺ T cell proliferation, while increasing the frequency of IL - 10-producing CD4⁺ T cell responses. …"

Table 1_Circulating microRNA signatures as potential biomarkers differentiating diabetic, prediabetic, and healthy individuals.docx حسب Hanifa J. Abu-Toamih Atamni (22555724)

"…Introduction<p>Circulating microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and play key roles in metabolic diseases, including diabetes. …"

Table 6_Epizootic shell disease induces systemic transcriptomic shifts in Homarus americanus, characterized by increased shell degradation and impaired energy metabolism across tis... حسب Minseo Kim (773205)

"…The hepatopancreas showed decreased expression of hemocyanin genes, which play key roles in oxygen transport and immune defense in crustaceans. …"

Presentation 1_Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice.zip حسب Xue-Ying Zhang (144147)

"…Instruction<p>Accumulating evidence has shown that proprotein convertase subtilisin/kexin type 9 (PCSK9) is associated with inflammation in the vascular system. However, the roles of PCSK9 in hepatic inflammation remain unclear. …"

Data Sheet 1_Identification of key genes and immune infiltration mechanisms in limb ischemia-reperfusion injury: a bioinformatics and experimental study.docx حسب Qiyun Shi (5531150)

"…</p>Results<p>From 169 differentially expressed genes (116 upregulated, 53 downregulated), machine learning identified four key genes (WNT5A, PLCG, ITPR1, CAMK2A), significantly upregulated in experimental limb IRI (P<0.01). …"

Image 1_Inhibition of CRM1 reverses hypoxia-driven chemoresistance in acute myeloid leukemia via overcoming HIF-1α-mediated lysosomal sequestration.jpeg حسب Xiaohui Feng (2869535)

"…Combination treatment with Selinexor and DNR significantly increased apoptosis and DNA damage in vitro and reduced leukemia burden in zebrafish xenografts.…"

Table 1_Epizootic shell disease induces systemic transcriptomic shifts in Homarus americanus, characterized by increased shell degradation and impaired energy metabolism across tis... حسب Minseo Kim (773205)

"…The hepatopancreas showed decreased expression of hemocyanin genes, which play key roles in oxygen transport and immune defense in crustaceans. …"

Table 4_Epizootic shell disease induces systemic transcriptomic shifts in Homarus americanus, characterized by increased shell degradation and impaired energy metabolism across tis... حسب Minseo Kim (773205)

"…The hepatopancreas showed decreased expression of hemocyanin genes, which play key roles in oxygen transport and immune defense in crustaceans. …"

Table 3_Epizootic shell disease induces systemic transcriptomic shifts in Homarus americanus, characterized by increased shell degradation and impaired energy metabolism across tis... حسب Minseo Kim (773205)

"…The hepatopancreas showed decreased expression of hemocyanin genes, which play key roles in oxygen transport and immune defense in crustaceans. …"

Image 2_Inhibition of CRM1 reverses hypoxia-driven chemoresistance in acute myeloid leukemia via overcoming HIF-1α-mediated lysosomal sequestration.jpeg حسب Xiaohui Feng (2869535)

"…Combination treatment with Selinexor and DNR significantly increased apoptosis and DNA damage in vitro and reduced leukemia burden in zebrafish xenografts.…"

Table 2_Epizootic shell disease induces systemic transcriptomic shifts in Homarus americanus, characterized by increased shell degradation and impaired energy metabolism across tis... حسب Minseo Kim (773205)

"…The hepatopancreas showed decreased expression of hemocyanin genes, which play key roles in oxygen transport and immune defense in crustaceans. …"

Table 7_Epizootic shell disease induces systemic transcriptomic shifts in Homarus americanus, characterized by increased shell degradation and impaired energy metabolism across tis... حسب Minseo Kim (773205)

"…The hepatopancreas showed decreased expression of hemocyanin genes, which play key roles in oxygen transport and immune defense in crustaceans. …"

Table 1_Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice.docx حسب Xue-Ying Zhang (144147)

"…Instruction<p>Accumulating evidence has shown that proprotein convertase subtilisin/kexin type 9 (PCSK9) is associated with inflammation in the vascular system. However, the roles of PCSK9 in hepatic inflammation remain unclear. …"