Data Sheet 1_The response regulator CrsR positively regulates ansamitocin P-3 biosynthesis in Actinosynnema pretiosum.docx by Peipei Zhang (1360440)

“…Deletion of the response regulator gene crsR drastically decreased AP-3 production. RNA-seq revealed CrsR’s global regulatory role, significantly altering transcription of primary metabolic genes, especially those in purine metabolism. …”

Image 2_Disruption of CDK5 regulatory subunit 1, p35, limits immunosuppressive M2 macrophages while maintaining functional M1 macrophages.tiff by Juliana R. Zampieri (22261441)

“…While p35 was important for antigen processing by M0 and M2, M1 were able to maintain capacity to process antigen albeit with a reduction due to decreased stability of peptide: MHC II complex.…”

Table 1_Waning neutralizing antibodies through 180 days after homologous and heterologous boosters of inactivated COVID-19 vaccine.docx by Zhifei Chen (1740625)

“…Across all booster groups, neutralizing antibodies against the wild-type virus declined sharply within the first 90 days, accounting for an 81.24 to 92.34% reduction, then slowed down with gradually decreasing decay rates. By day 14 of post-boost, the ability to neutralize the Delta variant slightly diminished compared to the wild-type, whereas neutralizing antibodies against the Omicron variant exhibited a more pronounced decline, ranging from 10.78 to 19.88 times lower than those against the wild-type. …”

Image 1_Disruption of CDK5 regulatory subunit 1, p35, limits immunosuppressive M2 macrophages while maintaining functional M1 macrophages.tiff by Juliana R. Zampieri (22261441)

“…While p35 was important for antigen processing by M0 and M2, M1 were able to maintain capacity to process antigen albeit with a reduction due to decreased stability of peptide: MHC II complex.…”

Image 3_Disruption of CDK5 regulatory subunit 1, p35, limits immunosuppressive M2 macrophages while maintaining functional M1 macrophages.tiff by Juliana R. Zampieri (22261441)

“…While p35 was important for antigen processing by M0 and M2, M1 were able to maintain capacity to process antigen albeit with a reduction due to decreased stability of peptide: MHC II complex.…”

Data Sheet 2_Menthone lowers H3K27ac levels to inhibit Fusarium proliferatum growth.xlsx by Li-Yan Zhang (5091608)

“…</p>Results<p>This study demonstrated that menthone, the primary component of Mentha haplocalyx EO, exhibited notable antifungal activity against Fusarium proliferatum (EC50 = 6.099 mmol/L). The treatment significantly inhibited hyphal growth, reduced spore germination rates from 31.49 to 4.95%, decreased spore viability from 46.88 to 20.91%, and reduced spore production by a factor of 17.92 compared with the control group while simultaneously enhancing cell membrane permeability. …”

Table1_Maslinic acid induces autophagy and ferroptosis via transcriptomic and metabolomic reprogramming in prostate cancer cells.xlsx by Fen Hu (342627)

“…Further, MA was observed to induce prostate cancer cell autophagy by increasing the expression of p53, p-p53, ULK1, Beclin1, Atg7, and Atg5 and the ratio of LC3-II/I and concurrently decreasing the expression of ERK1/2 and mTOR. In addition, MA induced RM-1 cell ferroptosis by regulating glutathione, glutamate, and oxidized glutathione concentrations, inhibiting SLC7A11 activity, and downregulating GPX4 expression. …”

Table3_Maslinic acid induces autophagy and ferroptosis via transcriptomic and metabolomic reprogramming in prostate cancer cells.xlsx by Fen Hu (342627)

“…Further, MA was observed to induce prostate cancer cell autophagy by increasing the expression of p53, p-p53, ULK1, Beclin1, Atg7, and Atg5 and the ratio of LC3-II/I and concurrently decreasing the expression of ERK1/2 and mTOR. In addition, MA induced RM-1 cell ferroptosis by regulating glutathione, glutamate, and oxidized glutathione concentrations, inhibiting SLC7A11 activity, and downregulating GPX4 expression. …”

Table2_Maslinic acid induces autophagy and ferroptosis via transcriptomic and metabolomic reprogramming in prostate cancer cells.xlsx by Fen Hu (342627)

“…Further, MA was observed to induce prostate cancer cell autophagy by increasing the expression of p53, p-p53, ULK1, Beclin1, Atg7, and Atg5 and the ratio of LC3-II/I and concurrently decreasing the expression of ERK1/2 and mTOR. In addition, MA induced RM-1 cell ferroptosis by regulating glutathione, glutamate, and oxidized glutathione concentrations, inhibiting SLC7A11 activity, and downregulating GPX4 expression. …”

Data Sheet 1_Menthone lowers H3K27ac levels to inhibit Fusarium proliferatum growth.docx by Li-Yan Zhang (5091608)

“…</p>Results<p>This study demonstrated that menthone, the primary component of Mentha haplocalyx EO, exhibited notable antifungal activity against Fusarium proliferatum (EC50 = 6.099 mmol/L). The treatment significantly inhibited hyphal growth, reduced spore germination rates from 31.49 to 4.95%, decreased spore viability from 46.88 to 20.91%, and reduced spore production by a factor of 17.92 compared with the control group while simultaneously enhancing cell membrane permeability. …”

Data Sheet 5_Overexpression of NK4 gene in TU212 affects migratory activity in laryngeal squamous cell carcinoma.xls by Yixuan Huo (21783825)

“…Functional experiments showed that PLV-NK4-TU212 cells exhibited a significantly reduced migration rate, decreased proliferative ability, and increased apoptosis rate. …”

Data Sheet 3_Overexpression of NK4 gene in TU212 affects migratory activity in laryngeal squamous cell carcinoma.xls by Yixuan Huo (21783825)

“…Functional experiments showed that PLV-NK4-TU212 cells exhibited a significantly reduced migration rate, decreased proliferative ability, and increased apoptosis rate. …”

Data Sheet 6_Overexpression of NK4 gene in TU212 affects migratory activity in laryngeal squamous cell carcinoma.xls by Yixuan Huo (21783825)

“…Functional experiments showed that PLV-NK4-TU212 cells exhibited a significantly reduced migration rate, decreased proliferative ability, and increased apoptosis rate. …”

Data Sheet 1_Overexpression of NK4 gene in TU212 affects migratory activity in laryngeal squamous cell carcinoma.xls by Yixuan Huo (21783825)

“…Functional experiments showed that PLV-NK4-TU212 cells exhibited a significantly reduced migration rate, decreased proliferative ability, and increased apoptosis rate. …”

Data Sheet 2_Overexpression of NK4 gene in TU212 affects migratory activity in laryngeal squamous cell carcinoma.xls by Yixuan Huo (21783825)

“…Functional experiments showed that PLV-NK4-TU212 cells exhibited a significantly reduced migration rate, decreased proliferative ability, and increased apoptosis rate. …”

Data Sheet 4_Overexpression of NK4 gene in TU212 affects migratory activity in laryngeal squamous cell carcinoma.xls by Yixuan Huo (21783825)

“…Functional experiments showed that PLV-NK4-TU212 cells exhibited a significantly reduced migration rate, decreased proliferative ability, and increased apoptosis rate. …”

DataSheet1_Drought induces opposite changes in organ carbon and soil organic carbon to increase resistance on moso bamboo.pdf by Xiaogai Ge (594675)

“…In the control treatments, SC of leaves were significantly positively correlated with ROC, NSC of branches were positively correlated with ROC and MBC, NSC of roots were significantly positively correlated with SOC.…”

Table 1_Impact of short-term (24 h) blood pressure variability on 30-days clinical outcomes of acute strokes at two tertiary hospitals in Dar-es-Salaam.docx by Ayubu Eliesikia Mashambo (22596824)

“…Functional outcomes improved significantly by day 30: the Barthel Index increased, and mRS scores decreased. …”

Summertime bedroom overheating in un-airconditioned UK urban apartments: factors influencing subjective and objective sleep outcomes by Iuliana Hartescu (1249374)

“…</p><p dir="ltr">Results: Night-time (22.00-07.00) bedroom temperatures rose significantly during HN (range BL = 17.5-26.4°C; HN = 22.0-29.3°C, p<0.001) with thermal comfort (p<0.001), ‘restfulness’ (p<0.001) and TST (p<0.05) significantly decreasing, while heat-related sleep disturbance significantly increased (p<0.001). …”

Short-term antiretroviral therapy may not correct the dysregulations of plasma virome and cytokines induced by HIV-1 infection by Yingying Ma (3617810)

“…Notably, most dysregulated cytokines were not fully restored by ART, with extremely abnormal levels of IL-10, GM-CSF, VEGF, and eotaxin, and a significantly increased level of plasma I-FABP. …”