Image 2_NK cell-derived extracellular vesicles enhance cytotoxicity and immune cell recruitment in non-small cell lung cancer.jpg by Joanna Palade (17712960)

“…Next, we examined the functional capabilities of patient NKEVs in organoid structures derived from primary tumor cells, finding that exposure to patient NKEVs resulted in a 40-45% decrease in organoid viability, and significantly lowered the cisplatin dose required to elicit cytotoxicity. …”

Table 5_NK cell-derived extracellular vesicles enhance cytotoxicity and immune cell recruitment in non-small cell lung cancer.xlsx by Joanna Palade (17712960)

“…Next, we examined the functional capabilities of patient NKEVs in organoid structures derived from primary tumor cells, finding that exposure to patient NKEVs resulted in a 40-45% decrease in organoid viability, and significantly lowered the cisplatin dose required to elicit cytotoxicity. …”

Table 1_Late-onset first epileptic seizure and cerebral small vessel disease: role of juxtacortical white matter lesions.docx by Adrian Nasca (20601542)

“…</p>Significance<p>By using algorithm-based automated lesion segmentation software tools and VBM analysis we could highlight that a juxtacortical weighting of WML distribution and regionally decreased gray matter volume distinguished LOFES from TIA and PC groups in our sample.…”

Supplementary file 1_Temporal interaction information and laser evoked responses: preliminary results in fibromyalgia patients with small fibers pathology.docx by Livio Clemente (22152382)

“…Objectives<p>We propose a novel application of higher-order information-theoretic measures to assess the temporal interaction information (TII) between laser-evoked potentials (LEPs) and individual pain ratings in healthy subjects and patients with fibromyalgia (FM) affected by small fiber pathology.…”

Image 1_Anlotinib combined with tislelizumab in the treatment of primary small cell neuroendocrine carcinoma of the prostate: a case report and literature review.jpeg by Xin Fei (20466992)

“…Here, we report a case of small cell neuroendocrine carcinoma of the prostate with multiple metastases, whose disease rapidly progressed despite receiving EP and second-line systemic chemotherapy. …”

Bistability of equilibrium vaccination levels and the emergence of hysteresis loops in well-mixed populations. by Feng Fu (218124)

Data_Sheet_1_Subthreshold amyloid deposition, cerebral small vessel disease, and functional brain network disruption in delayed cognitive decline after stroke.docx by Jae-Sung Lim (532986)

“…Background<p>Although its incidence is relatively low, delayed-onset post-stroke cognitive decline (PSCD) may offer valuable insights into the “vascular contributions to cognitive impairment and dementia,” particularly concerning the roles of vascular and neurodegenerative mechanisms. We postulated that the functional segregation observed during post-stroke compensation could be disrupted by underlying amyloid pathology or cerebral small vessel disease (cSVD), leading to delayed-onset PSCD.…”

Table 1_Enhancement of oxaliplatin efficacy and amelioration of intestinal epithelial damage by Lactobacillus rhamnosus GG through modulation of gut microbiota.xlsx by Zijie Zhang (2543533)

“…Background<p>Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality worldwide, necessitating extensive research into effective treatment strategies. …”

Video 1_Anlotinib combined with tislelizumab in the treatment of primary small cell neuroendocrine carcinoma of the prostate: a case report and literature review.mp4 by Xin Fei (20466992)

“…Here, we report a case of small cell neuroendocrine carcinoma of the prostate with multiple metastases, whose disease rapidly progressed despite receiving EP and second-line systemic chemotherapy. …”

Video 2_Anlotinib combined with tislelizumab in the treatment of primary small cell neuroendocrine carcinoma of the prostate: a case report and literature review.mp4 by Xin Fei (20466992)

“…Here, we report a case of small cell neuroendocrine carcinoma of the prostate with multiple metastases, whose disease rapidly progressed despite receiving EP and second-line systemic chemotherapy. …”

Data Sheet 1_Non-stationary response of Pacific saury (Cololabis saira) in the northwestern Pacific to climate variability.docx by Chang Cao (2592700)

“…The dynamics of Pacific saury from 1970 to 2021 could be divided into four periods: the 1970s and 1980s when the Siberian High and the intensification of the East Asian winter monsoon drove down the water temperature, providing a suitable habitat and resulting in an increase in resource abundance; In the 1990s, the rise in temperature led to a reduction in resource abundance; At the beginning of the 21st century, the enhancement of the Siberian High brought about a suitable habitat, and the resource abundance showed a significant increase; The unfavorable high water temperature environment in the 2010s caused the resource abundance to decrease once again. …”

DataSheet1_Apoptotic and proliferative processes in the small intestine of rats with type 2 diabetes mellitus after metformin and propionic acid treatment.PDF by Larysa Natrus (9397898)

“…Western blotting, RT-PCR, and scanning electron microscopy were performed.</p>Results<p>We observed profound changes in the SI of diabetic rats suggesting the disturbed intestinal homeostasis: impaired mitochondrial ultrastructure, increased cristae volume, and decreased content of proliferative marker Ki67 with almost unchanged proapoptotic caspase-3 and its p17 subunit levels. …”

Data Sheet 1_Induction immunochemotherapy followed by definitive chemoradiotherapy and consolidation immunotherapy for unresectable stage III non-small cell lung cancer: a multi-in... by Zhixue Fu (7540256)

“…We investigated whether incorporating induction immunochemotherapy enhances the efficacy.…”

Table 1_Sex-specific association between body mass index and cerebral microbleed progression in adults aged 50–85 years.docx by Cindy W. Yoon (10146428)

“…In women, each 1 kg/m² increase in BMI was significantly associated with a decrease in the 2-year change in the number of total CMBs after adjustment for age and baseline CMB count [β = −0.120, 95% confidence interval (CI): −0.202 to −0.037, p = 0.005]. …”

Table 1_Transcriptomic analysis of ROS1+ non-small cell lung cancer reveals an upregulation of nucleotide synthesis and cell adhesion pathways.xlsx by Marc Terrones (18094462)

“…When comparing ROS1+ tumor versus cell line transcriptomes, an upregulation of MYC and MET was found in cell lines together with a significantly decreased expression of HER3, HER4 and BRAF. …”

Image 2_Spatial deciphering of the transcriptomic heterogeneity of tumor spread through air spaces in lung cancer.tif by Wenhao Wang (515852)

“…Background<p>Spread through air spaces (STAS) represents a novel invasion mechanism in adenocarcinoma that considerably influences lung cancer clinical outcomes; however, studies of its mechanisms at the spatial level are lacking.</p>Methods<p>We used the NanoString GeoMx digital spatial profiling (DSP) technology to conduct a spatial transcriptomic analysis of surgically resected tissues from non-small-cell lung cancer (NSCLC) patients with or without STAS.…”

Image 4_Spatial deciphering of the transcriptomic heterogeneity of tumor spread through air spaces in lung cancer.tif by Wenhao Wang (515852)

“…Background<p>Spread through air spaces (STAS) represents a novel invasion mechanism in adenocarcinoma that considerably influences lung cancer clinical outcomes; however, studies of its mechanisms at the spatial level are lacking.</p>Methods<p>We used the NanoString GeoMx digital spatial profiling (DSP) technology to conduct a spatial transcriptomic analysis of surgically resected tissues from non-small-cell lung cancer (NSCLC) patients with or without STAS.…”

Data Sheet 1_Spatial deciphering of the transcriptomic heterogeneity of tumor spread through air spaces in lung cancer.zip by Wenhao Wang (515852)

“…Background<p>Spread through air spaces (STAS) represents a novel invasion mechanism in adenocarcinoma that considerably influences lung cancer clinical outcomes; however, studies of its mechanisms at the spatial level are lacking.</p>Methods<p>We used the NanoString GeoMx digital spatial profiling (DSP) technology to conduct a spatial transcriptomic analysis of surgically resected tissues from non-small-cell lung cancer (NSCLC) patients with or without STAS.…”

Image 1_Spatial deciphering of the transcriptomic heterogeneity of tumor spread through air spaces in lung cancer.tif by Wenhao Wang (515852)

“…Background<p>Spread through air spaces (STAS) represents a novel invasion mechanism in adenocarcinoma that considerably influences lung cancer clinical outcomes; however, studies of its mechanisms at the spatial level are lacking.</p>Methods<p>We used the NanoString GeoMx digital spatial profiling (DSP) technology to conduct a spatial transcriptomic analysis of surgically resected tissues from non-small-cell lung cancer (NSCLC) patients with or without STAS.…”

Image 3_Spatial deciphering of the transcriptomic heterogeneity of tumor spread through air spaces in lung cancer.tif by Wenhao Wang (515852)

“…Background<p>Spread through air spaces (STAS) represents a novel invasion mechanism in adenocarcinoma that considerably influences lung cancer clinical outcomes; however, studies of its mechanisms at the spatial level are lacking.</p>Methods<p>We used the NanoString GeoMx digital spatial profiling (DSP) technology to conduct a spatial transcriptomic analysis of surgically resected tissues from non-small-cell lung cancer (NSCLC) patients with or without STAS.…”