Dexmedetomidine improves septic acute kidney injury by inhibiting inflammation and oxidative stress through the activation of the Pink1/Park2 autophagy pathway حسب Qiuxia Liao (21507933)

"…Notably, all results were statistically significant. Overall, our findings revealed that dexmedetomidine may mitigate inflammation, oxidative stress, and renal dysfunction in mice with SAKI by upregulating the Pink1/Park2-mediated autophagy pathway. …"

Image 1_Exploring the antibacterial and anti-biofilm properties of Diacerein against methicillin-resistant Staphylococcus aureus.tif حسب Yingying Sun (568696)

"…Background<p>Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant clinical challenge due to its multidrug resistance. …"

ERICC Policy Brief_ Supporting children’s mental health and wellbeing in and through education in contexts of conflict and protracted crises حسب ERICC consortium (17060334)

"…., 2013), potentially decreasing attendance and retention rates as well as learning quality and continuity. …"

Data Sheet 4_Lathyrol inhibits the proliferation of Renca cells by altering expression of TGF-β/Smad pathway components and subsequently affecting the cell cycle.xlsx حسب Shengyou Song (22391068)

"…The TGF-β/Smad signaling pathway plays a significant role in the development and progression of RCC.…"

Data Sheet 3_Global, regional, and national burdens of pancreatitis in children and adolescents aged 0–24 years from 1992 to 2021: a trend analysis based on the global burden of di... حسب Ying-han Deng (21604157)

"…Background<p>The younger onset of pancreatitis presents a significant public health challenge. This study aims to analyze the global burden of pancreatitis in younger populations based on the Global Burden of Disease 2021.…"

Table 1_Specific drugs for rare diseases in a province of eastern China under catalog management: from 2021 to 2023.docx حسب Ruifang Nie (8200320)

"…The allocation of 19 drugs increased significantly, and 19 drugs were newly developed. The overall procurement cost of drugs increased and then decreased, which may be related to national policies. …"

Data Sheet 1_Integrative analysis of DNA methylation, RNA sequencing, and genomic variants in the cancer genome atlas (TCGA) to predict endometrial cancer recurrence.zip حسب Jin Hwa Hong (6523928)

"…Further validation using TCGA clinical data confirmed PARD6G-AS1 hypomethylation and CD44 overexpression as significant indicators of recurrence (p=0.006 and p=0.02, respectively), and both were linked to advanced stage and lymph node metastasis.…"

Data Sheet 1_Effects of COVID-19 nursing home restrictions on people with dementia involved in a Supportive Care programme.pdf حسب Omar Paccagnella (15432096)

"…</p>Results<p>NPI scores and number of reported symptoms in NPI evaluations increased over time among Supportive Care patients with dementia and decreased in the Control group. Differences are statistically significant. …"

Table 1_Exercise intolerance in patients with chronic coronary syndrome: insights from exercise stress echocardiography.docx حسب Wei-wei Zhu (20349897)

"…An elevated peak EDVi/E/e’ and a decreased ΔSVi are independent risk factors for exercise intolerance in patients with CCS.…"

Supplementary Material for: Analysis of Brain Functional Connectivity in Patients with Delayed Encephalopathy After Carbon Monoxide Poisoning Based on Functional Near-Infrared Spec... حسب figshare admin karger (2628495)

"…Compared with the control group, the brain network of DEACMP patients showed heterogeneity from left PC to right PC; Left PC~Left PMC; Left PC~right PMC; Left PC~Left DLPFC ,etc.The functional connectivity strength between the left PC and the right DLPFC area has significantly decreased. All these differences were statistically significant (P<0.05, FDR adjusted). …"

Table 1_Comparative study of flow rate- and material-dependent human plasma protein adsorption on oxygenator membranes and heat exchanger materials.pdf حسب Katharina Große-Berkenbusch (21559466)

"…Protein adsorption to the membrane types did not vary to a large extent, but a decreased flow rate significantly reduced the differences in protein adsorption between both membrane types and led to the adhesion of significantly higher amounts of inhibitory proteins C1INH and α1-AT. …"

Table_1_Effectiveness of Korean medicine treatments in improving cognitive function and prefrontal cortex activity in older individuals with mild cognitive impairment: retrospectiv... حسب Yujin Choi (4350172)

"…Additionally, the deoxygenated hemoglobin beta coefficient in the left frontopolar prefrontal cortex significantly decreased during the Stroop task after the intervention.…"

Image 1_Comparison between the protective effect of the orally administered atorvastatin and safflower (Carthamus tinctorius) in hypercholesterolemic male rats.pdf حسب Haddad A. El Rabey (22248019)

"…The induced hypercholesterolemia significantly raised liver function enzymes, lipid peroxidation (14.9 ± 0.11 mg/dL), total cholesterol (273.3 ± 1.1 mg/dL), triglycerides (223.0 ± 4.1 mg/dL), low-density lipoproteins (204.7 ± 0.9 mg/dL), very low-density lipoproteins (44.6 ± 0.8 mg/dL), troponin, creatine kinase (CK), and adrenaline while decreased antioxidant enzymes, high-density lipoprotein (HDL), and vitamin D (11.1 ± 0.5 ng/mL). …"

Table 1_Thiamine administration and in-hospital mortality in patients with traumatic brain injury: analysis of the MIMIC-IV database.docx حسب Shuangqi Gao (12729101)

"…In the univariable Cox regression analysis, thiamine administration was significantly associated with the reduced risk of in-hospital mortality in TBI patients admitted to the ICU. performing the multivariable Cox regression analysis, the observed association of thiamine administration and in-hospital mortality remained significant, with the hazard ratios (HR) of 0.66 [95% confidence interval (CI) = 0.45–0.98]. …"

Data Sheet 1_Cannabinoid receptor 2 selective agonist ameliorates adjuvant-induced arthritis by modulating the balance between Treg and Th17 cells.docx حسب Na Tian (296333)

"…Flow cytometry revealed that HU-308 restored the Th17/Treg imbalance in AIA, decreasing Th17 cell frequency and enhancing Treg cell infiltration. …"

Table 1_Comparison between the protective effect of the orally administered atorvastatin and safflower (Carthamus tinctorius) in hypercholesterolemic male rats.docx حسب Haddad A. El Rabey (22248019)

"…The induced hypercholesterolemia significantly raised liver function enzymes, lipid peroxidation (14.9 ± 0.11 mg/dL), total cholesterol (273.3 ± 1.1 mg/dL), triglycerides (223.0 ± 4.1 mg/dL), low-density lipoproteins (204.7 ± 0.9 mg/dL), very low-density lipoproteins (44.6 ± 0.8 mg/dL), troponin, creatine kinase (CK), and adrenaline while decreased antioxidant enzymes, high-density lipoprotein (HDL), and vitamin D (11.1 ± 0.5 ng/mL). …"

Table 4_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.csv حسب Zhenyu Zhao (737165)

"…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…"

Data Sheet 1_Lathyrol inhibits the proliferation of Renca cells by altering expression of TGF-β/Smad pathway components and subsequently affecting the cell cycle.xlsx حسب Shengyou Song (22391068)

"…The TGF-β/Smad signaling pathway plays a significant role in the development and progression of RCC.…"

Table 1_Efficacy of a novel surgical approach: sutureless correction of conjunctivochalasis using new conjunctival forceps combined with high-frequency electrocautery.docx حسب Tingting Song (575707)

"…OSDI scores showed no difference between preoperative (38.54) and 1-week postoperative (41.67) values (p=0.922), but significantly decreased by 1 month (16.67, p<0.001). …"

DPOAE differences (in dB SPL), post-scan minus pre-scan, as a function of the F2 frequency. حسب Eddy Fortier (20577301)

"…For each participant, graphs on the top row are for the left ear, while graphs on the bottom row are for the right ear. Significant amplitude decreases [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0309513#pone.0309513.ref049" target="_blank">49</a>] are highlighted with a red background. …"