Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…”

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…In ovariectomized mice, <b>5cc</b> administration (5 mg/kg) improved the trabecular microarchitecture, bone mineral density, and strength, at levels comparable to teriparatide, while significantly reducing bone resorption markers. With 13.57% oral bioavailability and selectivity for PDE1A1 (32% inhibition at 500 nM), <b>5cc</b> offers an innovative therapeutic candidate for PMO with a dual anabolic-antiresorptive profile and oral efficacy, warranting further clinical development.…”

Renal GRK4 knockdown impacted Mas receptor phosphorylation and Its-induced renal function in SHRs. by Lin Chen (54305)

Association between CAP value and carotid-femoral pulse wave velocity. by Johannes Nairz (18010746)

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Ischemic heart disease-related mortality trends in older adult population and stratified for census regions in 1999–2020. by Fakhar Latif (19760906)

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Conceptual framework of relationships between remittances and other individual, household and community-level factors and outcome measures, with potential confounders and unobserva... by Chelsea Ducille (21540080)

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Adjusted odds ratios of skilled delivery and skilled delivery with MAMA kits with community-level variables added one by one (Continuous remittance exposure). by Chelsea Ducille (21540080)

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Cases and age-standardized rates of hematological malignancies in mainland China and their temporal trends. by Yu Fu (16582)

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Relationship of amount of remittances and estimated probability of skilled delivery (adjusted model) n = 91. by Chelsea Ducille (21540080)

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Intra- and inter-observer agreement of all outcome measures, which were recorded on 26 video clips (excluding vocalisations, elimination behaviour and startle responses, which were... by Sara Hintze (3216885)

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Model outcomes (p-value, test statistic) for the fixed effects stimulus, age group and their interaction. by Sara Hintze (3216885)

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Socio-demographic characteristics of women in study sample (means except as noted). by Chelsea Ducille (21540080)

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Regression model summary outputs: Skilled delivery with MAMA kit (Binary exposure.). by Chelsea Ducille (21540080)

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Ischemic heart disease-related mortality trends in older adult population and stratified for metropolitan vs. non-metropolitan in 1999–2020. by Fakhar Latif (19760906)

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Relationship of amount of remittances and estimated probability of skilled delivery with MAMA Kit (adjusted model) n = 105. by Chelsea Ducille (21540080)

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Frequencies: Skilled delivery & skilled delivery with MAMA kit by exposure to remittances. by Chelsea Ducille (21540080)

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Regression model summary outputs: Skilled delivery (Binary exposure). by Chelsea Ducille (21540080)

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Adjusted odds ratios of skilled delivery and skilled delivery with MAMA kits with community-level variables added one by one (Binary remittance exposure). by Chelsea Ducille (21540080)

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Ischemic heart disease-related mortality trends in older adult population and stratified for gender in 1999–2020. by Fakhar Latif (19760906)

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Classification of the presumed valence of the tested stimuli and the results of our study. by Sara Hintze (3216885)

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