Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation حسب Huang-Ju Tu (630766)

"…Although the development of DYRK1A inhibitors has significantly advanced in recent years, the selectivity of these drugs remains a critical challenge, potentially impeding further progress. …"

Bioassay and NMR-HSQC-Guided Isolation and Identification of Phthalide Dimers with Anti-Inflammatory Activity from the Rhizomes of Angelica sinensis حسب Hongyan Wen (9226895)

"…Among them, compound <b>9</b> showed a remarkable inhibitory activity with IC₅₀ values of 425 nM and could significantly decrease IL-1β and IL-6 transcription levels. …"

Effects of Nitro-Substitution on the Spectroscopic and Self-Assembly Properties of BODIPY Dyes حسب Caroline Gwaro (21012411)

"…In a polar organic solvent, nitro-substitution tends to quench the characteristic fluorescence of BODIPYs, while in a nonpolar solvent, significantly higher absolute fluorescence quantum yields are observed. …"

Presentation_1_Src Inhibition Attenuates Neuroinflammation and Protects Dopaminergic Neurons in Parkinson’s Disease Models.PDF حسب Hanyu Yang (8374881)

"…The results showed that inhibition of Src could significantly relieve microgliosis and decrease levels of inflammatory factors. …"

Predicting the potential distribution of <i>Arisaema heterophyllum</i> in China under current and future climate change based on ArcGIS and MaxEnt model حسب Jing Xu (15337)

"…<p>Climate change significantly affects the distribution of medicinal plants, necessitating accurate models to predict future shifts in their habitats. …"

OMT حسب Jingmin Ou (19669426)

"…<p dir="ltr">In this study, we performed a series of experiments to investigate the effects of oxymatrine (OMT) on hemangioma cells and its mechanisms. OMT was found to significantly increase the apoptosis rate of endothelial cells (ECs) treated with oxidised low-density lipoprotein (ox-LDL), as measured by caspase-3 activity assay and flow cytometry. qRT-PCR results showed that OMT treatment decreased the expression of miR-199a-5p in ECs.Transfection of miR-199a-5p mimics enhanced the apoptotic effect, whereas miR-199a-5p inhibitors attenuated apoptosis, suggesting that miR-199a-5p has a key regulatory role in EC apoptosis. …"

Data Sheet 1_A ROS-responsive, aptamer-targeted graphene oxide nanocomposite for site-specific glutathione release in cerebral ischemia-reperfusion injury.docx حسب Meiying Li (6051287)

"…In vitro, GO@GSH-FA significantly restored viability in oxygen-glucose-deprived SH-SY5Y cells (from 31% up to near control levels), reduced inflammatory cytokines, and lowered intracellular ROS. …"

DataSheet1_FOXO1-mediated autophagy regulation by miR-223 in sepsis-induced immunosuppression.ZIP حسب Guoan Xiang (383282)

"…</p>Results<p>We found that when the expression of miR-223 increased, FOXO1 expression decreased and autophagy decreased; whereas, when FOXO1 expression was inhibited, autophagy decreased significantly in different cell models after LPS induction.…"

Data Sheet 1_Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization study.pdf حسب Kaiwen Wang (838527)

"…</p>Results<p>There was no causal relationship between sex hormones and IBD in women (P > 0.05), and there was a causal and positive correlation between SHBG and testosterone and IBD in men.The OR for SHBG was 1.22 (95% CI: 1.09-1.37, P = 0.0004), and for testosterone was 1.20 (95% CI: 1.04-1.39, P = 0.0145).IBD did not significantly interact with female sex hormones but resulted in a decrease in SHBG (OR = 1.02, 95% CI: 1.00-1.04, P = 0.0195) and testosterone (OR = 1.01, 95% CI: 1.00 -1.02, P = 0.0200) in men.…"

A rapid behavioral toxicity test using common periwinkle <i>Littorina littorea</i> (Gastropoda: Littorinidae) حسب Bjørn Henrik Hansen (1636042)

"…The exposure resulted in a concentration-dependent decrease in active suction, with snails retracting into their shells, which significantly reduced their oxygen consumption, indicating avoidance behavior. …"

Data Sheet 1_Assessment of heat-killed E. coli expressing Chikungunya virus E2 protein as a candidate vaccine for dual protection against Chikungunya virus and E. coli.docx حسب Surajit Patra (18400578)

"…Similarly, the vaccine formulation also elicited a significantly higher IgG immune response against E. coli. …"

DataSheet2_FOXO1-mediated autophagy regulation by miR-223 in sepsis-induced immunosuppression.ZIP حسب Guoan Xiang (383282)

"…</p>Results<p>We found that when the expression of miR-223 increased, FOXO1 expression decreased and autophagy decreased; whereas, when FOXO1 expression was inhibited, autophagy decreased significantly in different cell models after LPS induction.…"

<i>E²GO</i>: Free Your Hands for Smartphone Interaction حسب Shaoming Yan (21339553)

"…We also integrated an event-triggering mechanism in <math><mrow><mrow><mi>E</mi></mrow><mn>2</mn>GO</mrow></math> to significantly decrease its power consumption to deploy on smartphones. …"

Data for Moreno and Teixido. 2025. Journal of Animal Ecology حسب MHT Moreno (20967645)

"…Behaviour also showed an increase in negative impacts and a decrease in positive impacts in invertebrates compared to vertebrates.. …"

Calcium Changes Following a Neighboring Cell Death حسب Sriram Selvakumaran (22386294)

"…The experiment revealed a sharp intracellular calcium spike in astrocytes following adjacent cell death, followed by a sustained decrease below baseline levels. Suramin-treated cells showed significantly reduced amplitude and peak rise, indicating that ATP-mediated activation of P2 receptors contributes to calcium influx.…"

Image 5_Syzygium aromaticum extract mediated, sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities.jpeg حسب Zehra Edis (20561825)

"…<p>Microorganisms are becoming resistant to drugs and antimicrobials, making it a significantly critical global issue. Nosocomial infections are resulting in alarmingly increasing rates of morbidity and mortality. …"

Age-Dependent Impacts of Lighting Conditions on Contrast Sensitivity and Subjective Visual Perception Focusing on Pupil Size and Crystalline Lens Transmittance حسب Taisuke Eto (17892397)

"…Furthermore, we measured spectral crystalline lens transmittance and pupil size, and investigated relationships between visual-related measurements and ophthalmologic characteristics. Log CS significantly decreased in older adults and increased with increasing illuminance, regardless of age group or CCT. …"

Data Sheet 1_Syzygium aromaticum extract mediated, sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities.pdf حسب Zehra Edis (20561825)

"…<p>Microorganisms are becoming resistant to drugs and antimicrobials, making it a significantly critical global issue. Nosocomial infections are resulting in alarmingly increasing rates of morbidity and mortality. …"

Structural insulation panel system (SIP) as an alternative for cooling energy saving, decarbonization, and energy cost reduction in hot and dry climates. A simulation-based approac... حسب Anibal Luna-León (20377095)

"…Likewise, to reduce the heat flow, a crucial element is evident, since transmittance in thermal bridges significantly affects the heat transfer in these low thermal conductivity systems with structural reinforcement elements.…"

Supplementary file 1_Benzophenone-3 remodels gut microbiota diet-dependently to exacerbate non-alcoholic fatty liver disease in zebrafish.docx حسب Junyan Tao (131992)

"…Co-exposure to BP3 and HFD significantly worsened hepatic steatosis, as evidenced by increased triglyceride levels, lipid droplets accumulation, and oxidative damage (elevated hepatic MDA levels and decreased hepatic CAT activity). …"