Table4_Single-cell RNA sequencing analysis identifies acute changes in the tumor microenvironment induced by interferon α gene therapy in a murine bladder cancer model.xls by Alexis R. Steinmetz (18573319)

“…We established an immunocompetent murine BLCA model to study the effects of murine adenoviral IFNα (muAd-Ifnα) gene therapy on cancer cells and the tumor microenvironment using a novel murine equivalent of Nadofaragene firadenovec (muAd-Ifnα).…”

Presentation1_Single-cell RNA sequencing analysis identifies acute changes in the tumor microenvironment induced by interferon α gene therapy in a murine bladder cancer model.pptx by Alexis R. Steinmetz (18573319)

“…We established an immunocompetent murine BLCA model to study the effects of murine adenoviral IFNα (muAd-Ifnα) gene therapy on cancer cells and the tumor microenvironment using a novel murine equivalent of Nadofaragene firadenovec (muAd-Ifnα).…”

Table7_Single-cell RNA sequencing analysis identifies acute changes in the tumor microenvironment induced by interferon α gene therapy in a murine bladder cancer model.csv by Alexis R. Steinmetz (18573319)

“…We established an immunocompetent murine BLCA model to study the effects of murine adenoviral IFNα (muAd-Ifnα) gene therapy on cancer cells and the tumor microenvironment using a novel murine equivalent of Nadofaragene firadenovec (muAd-Ifnα).…”

Data Sheet 1_Identification of key genes and immune infiltration mechanisms in limb ischemia-reperfusion injury: a bioinformatics and experimental study.docx by Qiyun Shi (5531150)

“…</p>Conclusion<p>We identified a conserved molecular signature across cardiac and skeletal muscle IRI, with WNT5A/PLC pathway components as mechanistically validated therapeutic targets. …”

Data Sheet 1_Identification of a multiple DAMP scavenger mimicking the DAMP-binding site of TLR4 to ameliorate lethal sepsis.pdf by Takuya Murao (114383)

“…Endogenous molecules released from stressed or damaged cells, known as damage-associated molecular patterns (DAMPs), exacerbate inflammation, organ injury, and mortality in sepsis. In this study, we discovered a novel therapeutic compound, opsonic peptide 18 (OP18), designed to scavenge multiple DAMPs, including extracellular cold-inducible RNA-binding protein (eCIRP), high mobility group box 1 (HMGB1) and histone H3, by facilitating their clearance via macrophages. …”

Data Sheet 5_Causality of genetically determined serum metabolites on lower back pain or/and sciatica: a comprehensive Mendelian randomized study.pdf by Yi-Ming Ren (555968)

“…Among them, 8 serum metabolites decreased risk of sciatica or/and lower back pain significantly (P < 0.05), and 14 serum metabolites increased risk of sciatica or/and lower back pain significantly (P < 0.05). …”

Data Sheet 2_Causality of genetically determined serum metabolites on lower back pain or/and sciatica: a comprehensive Mendelian randomized study.xlsx by Yi-Ming Ren (555968)

“…Among them, 8 serum metabolites decreased risk of sciatica or/and lower back pain significantly (P < 0.05), and 14 serum metabolites increased risk of sciatica or/and lower back pain significantly (P < 0.05). …”

Data Sheet 6_Causality of genetically determined serum metabolites on lower back pain or/and sciatica: a comprehensive Mendelian randomized study.pdf by Yi-Ming Ren (555968)

“…Among them, 8 serum metabolites decreased risk of sciatica or/and lower back pain significantly (P < 0.05), and 14 serum metabolites increased risk of sciatica or/and lower back pain significantly (P < 0.05). …”

Data Sheet 3_Causality of genetically determined serum metabolites on lower back pain or/and sciatica: a comprehensive Mendelian randomized study.xlsx by Yi-Ming Ren (555968)

“…Among them, 8 serum metabolites decreased risk of sciatica or/and lower back pain significantly (P < 0.05), and 14 serum metabolites increased risk of sciatica or/and lower back pain significantly (P < 0.05). …”

Data Sheet 1_Causality of genetically determined serum metabolites on lower back pain or/and sciatica: a comprehensive Mendelian randomized study.docx by Yi-Ming Ren (555968)

“…Among them, 8 serum metabolites decreased risk of sciatica or/and lower back pain significantly (P < 0.05), and 14 serum metabolites increased risk of sciatica or/and lower back pain significantly (P < 0.05). …”

Data Sheet 4_Causality of genetically determined serum metabolites on lower back pain or/and sciatica: a comprehensive Mendelian randomized study.pdf by Yi-Ming Ren (555968)

“…Among them, 8 serum metabolites decreased risk of sciatica or/and lower back pain significantly (P < 0.05), and 14 serum metabolites increased risk of sciatica or/and lower back pain significantly (P < 0.05). …”

Data Sheet 1_A novel bivariate nomogram for predicting sequela vaginal lesions after surgery in patients with HPV-associated cervical cancer.docx by Yueheng Liu (9228588)

“…Ovarian preservation (OP) during hysterectomy and adenocarcinoma histology were found to be protective from further vaginal lesions, while elder age, FIGO stage II, and positive vaginal incision margin were significant risk factors. As for persistent HPV infection, both single and multiple genotype remarkably increased the risk of vaginal lesions, and a α-9 HPV infection (OR = 18.20) brought higher risk than non-α-9 HPV (OR = 11.76). …”

Presentation1_Systematic review of Buzhong Yiqi method in alleviating cancer-related fatigue: a meta-analysis and exploratory network pharmacology approach.PPTX by Ji Zeng (4336561)

“…Conversely, PFS, TCM syndrome score, and adverse reaction assessments significantly decreased. The primary active ingredients in its core drugs may exert a positive therapeutic effect on CRF by targeting molecules such as AKT1, IL6, IL1B, PTGS2, CASP3, ESR1, and BCL2, as well as through signaling pathways including TNF, IL17, TLR, NF-κB, and C-type lectin receptor.…”

Data Sheet 3_Comparative effectiveness of various combined interventions for type 2 diabetes and obesity: a systematic review and network meta-analysis.docx by Li Cui (37567)

“…Data extraction and quality assessment were independently conducted by two researchers, and Bayesian network meta-analysis was performed using R software.</p>Results<p>A total of 128 RCTs were included. ART showed the most significant improvements in BMI, IL-6, and TNF-α levels. …”

Data Sheet 1_Case Report: A case of first-line treatment for rare ROS1 fusion mutation lung adenocarcinoma with entrectinib.pdf by Yifan Yang (170387)

“…At least 55 partner genes have been identified that can fuse with ROS1.Herein, we report a case of a lung adenocarcinoma patient harboring a rare ROS1 fusion mutation with brain metastasis, who achieved good control of both lung and intracranial lesions after treatment with Entrectinib. …”

Supplementary file 1_Healthy lifestyle moderates the association between recent negative life events and depressive symptoms: a cross-sectional study.docx by Yang Yang (45629)

“…We aim to explore the modifying role of adopting a healthy lifestyle in the association between RNLEs and depressive symptoms.…”

Data Sheet 2_Comparative effectiveness of various combined interventions for type 2 diabetes and obesity: a systematic review and network meta-analysis.zip by Li Cui (37567)

“…Data extraction and quality assessment were independently conducted by two researchers, and Bayesian network meta-analysis was performed using R software.</p>Results<p>A total of 128 RCTs were included. ART showed the most significant improvements in BMI, IL-6, and TNF-α levels. …”

Table 1_Global, regional, and national disease burden and economic costs of cervical cancer (1991–2021): a multidimensional data synthesis analysis.docx by Yidi Ma (9507153)

“…Objectives<p>Cervical cancer remains a significant global health concern, particularly in less developed regions. …”

Data Sheet 1_Comparative effectiveness of various combined interventions for type 2 diabetes and obesity: a systematic review and network meta-analysis.zip by Li Cui (37567)

“…Data extraction and quality assessment were independently conducted by two researchers, and Bayesian network meta-analysis was performed using R software.</p>Results<p>A total of 128 RCTs were included. ART showed the most significant improvements in BMI, IL-6, and TNF-α levels. …”

Table 1_Abnormal subthalamic nucleus functional connectivity and machine learning classification in Parkinson’s disease: a multisite functional magnetic resonance imaging study.doc... by Bin Qin (544949)

“…Introduction<p>Parkinson’s disease (PD) is a progressive neurodegenerative disorder imposing a significant global burden, characterized by motor dysfunction linked to aberrant basal ganglia activity. …”