Functional Delivery Systems for Targeting Tumor Heterogeneity: Reversing Immunosuppression and Modulating Cancer-Immune Interplay by Di Han (618795)

“…By developing a delivery vector that specifically targets circulating malignant cells (CMCs) in patient blood samples, we established an ex vivo platform to study the dynamic interplay between patient-derived cancer cells and immune cells. …”

Functional Delivery Systems for Targeting Tumor Heterogeneity: Reversing Immunosuppression and Modulating Cancer-Immune Interplay by Di Han (618795)

“…By developing a delivery vector that specifically targets circulating malignant cells (CMCs) in patient blood samples, we established an ex vivo platform to study the dynamic interplay between patient-derived cancer cells and immune cells. …”

Summary of KEGG enrichment analysis. by Zeynab Hosseinpoor (19762319)

“…<i>MIR-96</i> regulates protein cascades in inflammatory and insulin signaling pathways, but further investigation is required to understand its potential effects on related genes. For this purpose, we identified a series of key target genes for <i>MIR-96</i> based on gene and protein interaction networks and utilized text-mining resources. …”

Histogram of the area factorψ. by Hong Zhang (25820)

“…The measured <i>I</i>_s decreases following a power-law trend as <i>β</i> and <i>D</i> increase, with weathering reducing the sensitivity of <i>I</i>_s to <i>β</i> but not significantly altering its sensitivity to <i>D</i>. …”

Raw dataset Fig. 6. by Hong Zhang (25820)

“…The measured <i>I</i>_s decreases following a power-law trend as <i>β</i> and <i>D</i> increase, with weathering reducing the sensitivity of <i>I</i>_s to <i>β</i> but not significantly altering its sensitivity to <i>D</i>. …”

Schematic for measuring <i>D</i> and <i>D</i>′ values. by Hong Zhang (25820)

“…The measured <i>I</i>_s decreases following a power-law trend as <i>β</i> and <i>D</i> increase, with weathering reducing the sensitivity of <i>I</i>_s to <i>β</i> but not significantly altering its sensitivity to <i>D</i>. …”

Primer sequences for RT-qPCR. by Wenlong Shen (9313937)

“…<div><p>The aim of this study was to investigate how the cholangiocarcinoma cell lines RBE and HCCC-9810 responded to NCOA4 downregulation in terms of proliferation, migration and invasive.First,we analyzed the differential expression and survival prognosis of the NCOA4 gene using a bioinformatic approach,as well as validation using clinical samples.Next,cholangiocarcinoma cells were cultured and the NCOA4 gene was down-regulated with siRNA,and then NCOA4 and GPX4 expression was detected using qPCR and Western blot.Cell was measured using CCK8, cell cloning, wound healing, and transwell migration and invasion.Levels of changes in indicators related to ferroptosis were measured after induction of iron metamorphosis by Erastin. …”

siRNA sequences and negative controls sequences. by Wenlong Shen (9313937)

“…<div><p>The aim of this study was to investigate how the cholangiocarcinoma cell lines RBE and HCCC-9810 responded to NCOA4 downregulation in terms of proliferation, migration and invasive.First,we analyzed the differential expression and survival prognosis of the NCOA4 gene using a bioinformatic approach,as well as validation using clinical samples.Next,cholangiocarcinoma cells were cultured and the NCOA4 gene was down-regulated with siRNA,and then NCOA4 and GPX4 expression was detected using qPCR and Western blot.Cell was measured using CCK8, cell cloning, wound healing, and transwell migration and invasion.Levels of changes in indicators related to ferroptosis were measured after induction of iron metamorphosis by Erastin. …”

Antibodies used in the study. by Wenlong Shen (9313937)

“…<div><p>The aim of this study was to investigate how the cholangiocarcinoma cell lines RBE and HCCC-9810 responded to NCOA4 downregulation in terms of proliferation, migration and invasive.First,we analyzed the differential expression and survival prognosis of the NCOA4 gene using a bioinformatic approach,as well as validation using clinical samples.Next,cholangiocarcinoma cells were cultured and the NCOA4 gene was down-regulated with siRNA,and then NCOA4 and GPX4 expression was detected using qPCR and Western blot.Cell was measured using CCK8, cell cloning, wound healing, and transwell migration and invasion.Levels of changes in indicators related to ferroptosis were measured after induction of iron metamorphosis by Erastin. …”

We compared the Fugl-Meyer (FMA) clinical assessment scores for individuals with stroke with their performance for each outcome measure. by Devin Sean Austin (20285144)

The result of molecular dynamics simulation. by Ashraf Attia Mahmoud (21262201)

“…The docking research indicated that these mutations decreased the binding affinity for DNA, with R273C, R280G, G266E, and G105C displaying the most significant differences. …”

Result of the phenotypic analysis. by Ashraf Attia Mahmoud (21262201)

“…The docking research indicated that these mutations decreased the binding affinity for DNA, with R273C, R280G, G266E, and G105C displaying the most significant differences. …”

Type of Mutations. by Ashraf Attia Mahmoud (21262201)

“…The docking research indicated that these mutations decreased the binding affinity for DNA, with R273C, R280G, G266E, and G105C displaying the most significant differences. …”

Schematic diagram of numerical simulation model. by Mengyun Li (7490870)

“…<div><p>After prolonged waterflooding development, the main integrated oil reservoirs in the X Oilfield have largely entered the late stage of waterflooding, with an average water cut reaching approximately 98%. However, a significant amount of remaining oil still accumulates in the weak water-flushed zones of low-permeability layers, which presents substantial development potential. …”

Data Sheet 1_Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis.docx by David Qixiang Chen (8198265)

“…We present two case studies of MS patients who underwent a novel ibogaine treatment, highlighting significant neuroimaging changes and clinical improvements. …”

Data Sheet 2_Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis.docx by David Qixiang Chen (8198265)

“…We present two case studies of MS patients who underwent a novel ibogaine treatment, highlighting significant neuroimaging changes and clinical improvements. …”

Data Sheet 3_Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis.docx by David Qixiang Chen (8198265)

“…We present two case studies of MS patients who underwent a novel ibogaine treatment, highlighting significant neuroimaging changes and clinical improvements. …”

Row data. by Xiangyu Wang (341093)

“…Moreover, Life Sciences & Medicine students demonstrated a greater tendency toward negative self-perception, low psychological well-being level, and decreased creative self-efficacy, compared to peers in other disciplines.…”

Univariate linear regression analysis of scales. by Xiangyu Wang (341093)

“…Moreover, Life Sciences & Medicine students demonstrated a greater tendency toward negative self-perception, low psychological well-being level, and decreased creative self-efficacy, compared to peers in other disciplines.…”

Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras by Charles W. Parry (20966154)

“…Here we report the discovery of a novel series of reversible inhibitors that bind in an enlarged version of the switch I–II pocket with nanomolar affinities. …”