Causal impacts of 731 immunocyte phenotypes on colorectal cancer-evidence from a bidirectional two-sample Mendelian randomization حسب Xinyue Gu (7335398)

"…The inverse variance weighting results indicated that a total of 31 and 28 immune cell phenotypes significantly associated with colorectal cancer in two different datasets, respectively. …"

Supplementary file 1_Instability and uncertainty of carbon storage in karst regions under land use change: a case study in Guiyang, China.docx حسب Heng Zhou (287510)

"…By 2035, projections under natural development, urban expansion, and ecological protection scenarios estimate increases to 147.50 Tg, 147.40 Tg, and 147.82 Tg, respectively. (2) Carbon storage instability increased from 2000 to 2020, while uncertainty is expected to decrease by 2035. Instability was primarily due to transitions of Cropland-Forest, Forest-Cropland, Cropland-Grassland, and Cropland-Impervious, while uncertainties mainly arise from Cropland-Forest, Cropland-Impervious, and Grassland-Impervious transitions. (3) DEM, AI, Distance from national highways, SHDI, and Mean annual precipitation affected instability significantly. (4) Encouraging Shrub-Forest, Shrub-Cropland and Cropland-Forest conversions, and controlling Forest-Cropland, Forest-Shrub, and Cropland-Impervious conversions within the stable intervals of factors, can enhance carbon storage and reduce uncertainty. …"

Docetaxel and quercetin-loaded lipid nanocarrier optimized by quality by design for glioblastoma therapy: a ligand-conjugated and therapeutic repurposing approach حسب Zufika Qamar (22259678)

"…Compared to non-conjugated NLC and (DTX-QUR) suspension (SUS), Tf-(DTX-QUR) NLC showed 3.6- and 5.8-fold decrease in IC₅₀, respectively. Cellular uptake studies demonstrated significantly (<i>***p < 0.001</i>) high internalization of Tf-conjugated NLC to U87-MG cells. …"

Data Sheet 1_Incidence of hyperkalemia RAASi and SGLT-2i treatment in individuals with diabetic kidney disease: a systematic review and network meta-analysis.docx حسب Yahui Yuan (12112503)

"…SGLT-2i (SUCRA = 88.5%) was found to significantly reduce the risk of hyperkalemia. In contrast, the combination of ACEI/ARB + MRA (SUCRA = 5.7%) increased the risk of hyperkalemia. …"

Prior immunological memory to pertussis toxin affects the avidity development of anti-PT IgG antibodies after acellular pertussis booster vaccination حسب Aapo Knuutila (12239402)

"…The development of avidity from one month after vaccination to a year after was highly individual, with some participants having either a decrease, an increase or a stagnant level of avidity. …"

Image 1_Atractylenolide-I restore intestinal barrier function by targeting the S100A9/AMPK/mTOR signaling pathway.tif حسب Chen Chen (6544)

"…Transcriptomic analysis revealed that AT-1 significantly modulated the expression of S100A8 and S100A9. …"

<b>Insight into the effects of citric acid on the transformation of chemical</b><b> speciation</b><b> of Cd in</b> <b>biochar amended contaminated soil:</b> <b>Implications for bio... حسب Renhui Miao (18618601)

"…<p dir="ltr">Understanding the roles of low-molecular-weight organic acids (LMWOAs) in the transformation of chemical speciation of heavy metals in contaminated soil amended by biochar is of great significance for assessing the effectiveness of this carbonaceous amendment. …"

Data Sheet 1_Unveiling the mechanisms of American ginseng and achyranthes in treatment of primary Sjogren’s syndrome via mtDNA-cGAS-STING pathway insights from network pharmacology... حسب Haotian Li (640676)

"…Animal experiments demonstrated that baicalin can significantly reduce inflammatory cytokines of IL-18, TNF-α, IFN-α, and IFN-β,CXCL-10 (p < 0.05), decrease mtDNA release, and downregulate cGAS-STING pathway-related proteins including cGAS, STING, CASP3, ZBP1, TBK1, p-STING, p-TBK1, IRF3, p-IRF3 and BAX.…"

Mix details of samples (kg/m³). حسب Fadi Althoey (13040091)

"…Durability was enhanced with a 14–17% reduction in water absorption and sorptivity and a 25.2% decrease in chloride penetration. Acid resistance improved by 26%. …"

ASVs abundances across microbiota samples. حسب Melany Cervantes-Echeverría (22794116)

"…Despite persistent dietary stress, FVT significantly improved glucose tolerance. Longitudinal profiling by virome shotgun metagenomics and bacterial 16S rRNA sequencing revealed marked, durable shifts in both viral and bacterial community composition. …"

Image 1_Heat-not-burn technology affects plasma testosterone levels and markers of inflammation, oxidative stress in the testes of rats.pdf حسب Silvia Granata (2678077)

"…Furthermore, inactivation of key androgenic enzymes, such as 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase, together with decreased testosterone synthesis suggest a potential impairment of male gonadal function.…"

Table 2_Association between platelet-to-red cell distribution width ratio and all-cause mortality in critically ill patients with non-traumatic cerebral hemorrhage: a retrospective... حسب Rongrong Lu (322302)

"…Following adjustment for confounding factors, patients with elevated PRR exhibited a significantly decreased risk of in-hospital death (HR, 0.98; 95% CI, 0.96–0.99; p = 0.006) and ICU death (HR, 0.98; 95% CI, 0.96–0.99; p = 0.027). …"

Table 1_Cardiopulmonary exercise response at high altitude in patients with congenital heart disease: a systematic review and meta-analysis.pdf حسب Marco Vecchiato (4591219)

"…Nevertheless, the patients with CHD showed a smaller decrease in peak workload [10.61 W (95% CI: 2.33–18.88)] and peak saturation [1.22% (95% CI: 0.14–2.30)] between LA and HA compared to the controls. …"

DataSheet1_A lightweight MHDI-DETR model for detecting grape leaf diseases.pdf حسب Zilong Fu (20392494)

"…The original residual backbone network was improved using the MobileNetv4 network, significantly reducing the model’s computational requirements and complexity. …"

Table 1_Manure substitution for chemical nitrogen enhances soil quality without compromising maize yield: a short-term field experiment in Northeast China.xlsx حسب Chao Zhou (471522)

"…</p>Results and disscussion<p>Compared to CK, only 25% substitution rate maintained maize yield, while 50‒100% manure substitution decreased maize yield by 15.9‒67.2%. This is primarily due to the decrease in root biomass (13.5‒29.1%), length (14.8‒43.3%), surface area (14.1‒48.8%) and volume (17.9‒53.4%). …"

Image 1_Cardiopulmonary exercise response at high altitude in patients with congenital heart disease: a systematic review and meta-analysis.tif حسب Marco Vecchiato (4591219)

"…Nevertheless, the patients with CHD showed a smaller decrease in peak workload [10.61 W (95% CI: 2.33–18.88)] and peak saturation [1.22% (95% CI: 0.14–2.30)] between LA and HA compared to the controls. …"

Data Sheet 1_High intensity human activity limits ultra-high altitude soil microbial community dispersal and keystone taxa distribution in southeastern Tibetan Plateau.docx حسب Wenzu Liu (22364023)

"…Human activities increase the complexity of microbial networks but decrease the stability of soil micro-ecosystems. As elevtation increases, the dispersal limitation of microbial communities decreases (total effect size: bacterial = −0.705, fungal = −0.745). …"

Data Sheet 1_Effect of environmentally relevant concentrations of estrogens on the aggressive response of male zebrafish.docx حسب Ying–Ying Zhang (21776942)

"…Post-exposure assays (mirror test and dyadic interaction) revealed that Mix significantly reduced the frequency of approaching mirror, the attack mirror duration, and the frequency of chasing un-exposed fish, indicating a decrease in aggressive behaviour in Mix-fish. …"

Supplementary Material for: Feedback from human instructors is superior to guidance by a virtual reality simulator when learning flexible bronchoscopy – a randomized controlled tri... حسب figshare admin karger (2628495)

"…[Results] All three groups showed an improvement in SP, DC, PT and NASA-TLX during their 12 procedures (P<.05), without a decrease in performance three weeks later (P>0.05). …"

Ganaxolone: A Review in Epileptic Seizures Associated with Cyclin‑Dependent Kinase‑Like 5 Deficiency Disorder حسب Sheridan M. Hoy (4897468)

"…In a multinational phase III study (Marigold), 17 weeks’ therapy with adjunctive ganaxolone, administered orally three times daily with food, significantly reduced 28-day major motor seizure frequency from baseline versus placebo in patients aged 2–19 years with CDD-associated refractory epilepsy. …"