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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
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1361
Data Sheet 1_Global, regional, and national epidemiology of otitis media in children from 1990 to 2021.docx
Published 2025“…</p>Conclusion<p>OM in children represents an escalating global health challenge, marked by a rising incidence. Although there has been a global decline in DALYs, the burden of DALYs associated with OM in children remains significant, particularly in regions with a low SDI. …”
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1362
Data Sheet 1_Associations between glycan signature alterations and the cellular antigenic properties of passaged chondrocytes.docx
Published 2024“…Background<p>Cartilage repair is a significant clinical challenge because of the limited intrinsic healing capacity. …”
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1363
Data Sheet 1_Preliminary evaluation of a novel serotype O foot-and-mouth disease mRNA vaccine.docx
Published 2025“…The viral load results demonstrated that the vaccine group significantly reduced viral copy numbers in serum and effectively decreased the concentration of the inflammatory cytokine IL-1β. …”
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1364
Table 1_Telestroke management during the Hajj seasons 2023–2024: insights from SEHA Virtual Hospital in KSA.xlsx
Published 2025“…Background<p>The Hajj pilgrimage in Saudi Arabia poses significant healthcare challenges due to overcrowding and high demand. …”
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1365
Table 3_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.docx
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1366
Image 3_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.tif
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1367
Table 5_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.docx
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1368
Image 2_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.tif
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1369
DataSheet1_CircFOXO3 upregulation mediates the radioresistance of glioblastoma by affecting cellular metabolome.DOCX
Published 2024“…Introduction<p>Radioresistance remains a significant challenge in the treatment of glioblastoma multiforme (GBM), the most prevalent and lethal brain cancer in adults. …”
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1370
Table1_CircFOXO3 upregulation mediates the radioresistance of glioblastoma by affecting cellular metabolome.XLSX
Published 2024“…Introduction<p>Radioresistance remains a significant challenge in the treatment of glioblastoma multiforme (GBM), the most prevalent and lethal brain cancer in adults. …”
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1371
Table 1_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.docx
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1372
Table 4_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.docx
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1373
Table 2_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.docx
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1374
Data Sheet 1_Integrated computational and experimental identification of N-[(1H-1,2,4-triazol-3-yl)phenyl]-1-(1H-pyrazolo[3,4-b]pyridin-3-yl)methanamide as a potent and selective T...
Published 2025“…<p>Non-small cell lung cancer (NSCLC) remains a significant clinical challenge, necessitating exploration of novel therapeutic targets such as TIM-3. …”
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1375
Image 1_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.tif
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1376
Data Sheet 1_Global burden of Type 2 Diabetes Mellitus attributable to dietary risks in elderly adults: insights from the Global Burden of Disease study 2021.docx
Published 2025“…Background<p>Type 2 Diabetes Mellitus (T2DM) poses a significant global health challenge, particularly among elderly adults. …”
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1377
Table_1_Toward workforce integration: enhancements in adaptive behaviors and social communication skills among autistic young adults following vocational training course.DOCX
Published 2024“…Background<p>Cognitively able autistic adults demonstrate low rates of employment due to social and vocational challenges. The current study aimed to examine changes in various areas among autistic young adults who participated in the ‘Roim Rachok’ (‘Looking Ahead’ in Hebrew) Training Course (RRTC). …”
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1378
Data Sheet 1_Evaluation of tolerability and safety of transcranial electrical stimulation with gel particle electrodes in healthy subjects.pdf
Published 2024“…Additionally, fatigue increased, and energy levels decreased on VAMS-R with longer durations. No significant differences were found in other neuropsychological tests.…”
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1379
Image 1_PipC affects the virulence of Salmonella enterica serovar Enteritidis and its deletion strain provides effective immune protection in mice.tif
Published 2025“…The results of the mouse intraperitoneal challenge experiment showed that compared with the wild-type strain, the 50% lethal dose (LD<sub>50</sub>) of the ΔpipC strain increased by 47 times, and the bacterial loads in the liver, spleen, and cecum were significantly reduced. …”
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1380
Supplementary file 1_Rotation of soybean and Corydalis yanhusuo enhances yield and active compounds of C. yanhusuo via soil nutrient optimisation and rhizosphere microbiome enginee...
Published 2025“…Microbial OTUs increased in the bulk soil, rhizosphere soil, and roots, along with significant improvements in α-diversity. Over time, the Proteobacteria and pathogenic genera decreased, while Firmicutes and other beneficial genera increased. …”