Supplemental_Figure_of_Imeglimin_ameliorate_SA-AKI by Hiroyasu Goto (12227927)

“…Serum ALT levels were not significantly different before and after E. coli challenge between the Ime and Veh groups. …”

Investigating the effects of ankle foot orthoses on electromyography in impaired populations: a systematic review by Sally Kenworthy (20873172)

“…</p><p>Longitudinal studies refute concerns about adverse effects on EMG activity with prolonged AFO use, challenging the notion of decreased muscle activation and supporting the safety of extended AFO utilization.…”

Supplementary file 1_Global burden of HIV, syphilis, and HBV infection among women of childbearing age and children under five: based on the Global Burden of Diseases Study 2021.do... by Jia Lian (9469818)

“…</p>Conclusion<p>In 2021, the global disease burden of HIV, syphilis, and HBV infection remained high among WCBA and children under five, with significant regional and demographic disparities. These findings indicate a persistent public health challenge, necessitating continued global efforts to mitigate the burden through addressing socioeconomic inequalities, strengthening health education, and expanding healthcare access.…”

Data_Sheet_1_Compound effects of biochar application and irrigation on soil water and temperature transport.docx by Fuchang Jiang (19966587)

“…Finding methods to enhance the quality of salinized soils while conserving water resources has become a pressing challenge. In arid and semi-arid environments, conserving water resources while maintaining soil health is a critical challenge. …”

Competition constrains the resistance and recovery of fungi to heat stress under low nutrient concentration by Jingjing Shi (20738168)

“…Yet, we know little about how biotic interactions among fungi, such as competition, may influence fungal stability against environmental stresses. For instance, a significant challenge is understanding the roles of competition in driving resistance (immediate response to stress) and recovery (response after the stress is over) of fungi under climate extremes, such as heat waves, particularly under variable resource availability. …”

Image 1_CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint.pdf by Kai Sun (140584)

“…Background<p>Charged Multivesicular Body Protein 4A (CHMP4A), a member of the ESCRT-III family, plays a pivotal role in membrane remodeling and fission, with emerging evidence underscoring its significance in cancer immunotherapy. The complex pathogenesis and therapeutic resistance characteristic of liver hepatocellular carcinoma (LIHC) present significant challenges in clinical practice. …”

Table 1_CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint.docx by Kai Sun (140584)

“…Background<p>Charged Multivesicular Body Protein 4A (CHMP4A), a member of the ESCRT-III family, plays a pivotal role in membrane remodeling and fission, with emerging evidence underscoring its significance in cancer immunotherapy. The complex pathogenesis and therapeutic resistance characteristic of liver hepatocellular carcinoma (LIHC) present significant challenges in clinical practice. …”

Table 2_CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint.docx by Kai Sun (140584)

“…Background<p>Charged Multivesicular Body Protein 4A (CHMP4A), a member of the ESCRT-III family, plays a pivotal role in membrane remodeling and fission, with emerging evidence underscoring its significance in cancer immunotherapy. The complex pathogenesis and therapeutic resistance characteristic of liver hepatocellular carcinoma (LIHC) present significant challenges in clinical practice. …”

Image 2_CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint.pdf by Kai Sun (140584)

“…Background<p>Charged Multivesicular Body Protein 4A (CHMP4A), a member of the ESCRT-III family, plays a pivotal role in membrane remodeling and fission, with emerging evidence underscoring its significance in cancer immunotherapy. The complex pathogenesis and therapeutic resistance characteristic of liver hepatocellular carcinoma (LIHC) present significant challenges in clinical practice. …”

Data Sheet 1_CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint.docx by Kai Sun (140584)

“…Background<p>Charged Multivesicular Body Protein 4A (CHMP4A), a member of the ESCRT-III family, plays a pivotal role in membrane remodeling and fission, with emerging evidence underscoring its significance in cancer immunotherapy. The complex pathogenesis and therapeutic resistance characteristic of liver hepatocellular carcinoma (LIHC) present significant challenges in clinical practice. …”

Table 1_GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells.xlsx by Fumiya Ito (14833366)

“…However, resistance to EGFR inhibitors, such as erlotinib, presents a significant challenge in treating lung cancer. In this study, we established an EGFR-independent, erlotinib-resistant (ER) phenotype in lung cancer A549 cells by exposing them to erlotinib for an extended period. …”

Data Sheet 1_GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells.pdf by Fumiya Ito (14833366)

“…However, resistance to EGFR inhibitors, such as erlotinib, presents a significant challenge in treating lung cancer. In this study, we established an EGFR-independent, erlotinib-resistant (ER) phenotype in lung cancer A549 cells by exposing them to erlotinib for an extended period. …”

Data Sheet 1_Effectiveness of community-based management models in chronic obstructive pulmonary disease: a systematic review and meta-analysis.docx by Miao Zhan (2625718)

“…Background<p>Chronic obstructive pulmonary disease (COPD) is a common fatal disease with high morbidity, disability, and economic burden, and it poses a major challenge to global public health. The limitations of the traditional hospital-based management models and the lack of continuous professional guidance and support for people with COPD after discharge have led to repeated acute exacerbations of the disease and high rates of rehospitalization. …”

The impact of chronic pain on the quality of life of patients attending soshanguve community health centre (CHC), Tshwane district, South Africa by Thanyani Pandelani (8218809)

“…<p dir="ltr">Background: Chronic pain poses a considerable challenge to individuals' well-being, leading to decreased quality of life, limitations in daily functioning, and a higher reliance on healthcare services, resulting in significant economic burdens. …”

Supplementary file 1_Efficacy of flavonoids in non-alcoholic fatty liver disease: an updated systematic review and meta-analysis.docx by Qianqian Liu (381114)

“…Flavonoids intervention significantly decreased aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT), total cholesterol (TC), steatosis score, body mass index (BMI), triglycerides (TG), fasting blood sugar (FBS), insulin levels and augmented the quantitative insulin sensitivity check index (QUICKI) levels. …”

Table 2_Epidemiological trends and future projections of ischemic stroke in children and adolescents: a global analysis from 1990 to 2021.docx by Yi Liu (36759)

“…Challenges include gender differences, regional inequalities, and environmental risks. …”

Table 1_Epidemiological trends and future projections of ischemic stroke in children and adolescents: a global analysis from 1990 to 2021.docx by Yi Liu (36759)

“…Challenges include gender differences, regional inequalities, and environmental risks. …”

Supplementary file 1_Cell wall modulation by drought and elevated CO2 in sugarcane leaves.docx by Alexandre Junio Borges Araujo (12977867)

“…<p>Climate change poses significant challenges to global agriculture, with elevated atmospheric CO2 (eCO₂) concentrations and increased frequency of droughts affecting crop productivity. …”

Data Sheet 3_Cell wall modulation by drought and elevated CO2 in sugarcane leaves.xlsx by Alexandre Junio Borges Araujo (12977867)

“…<p>Climate change poses significant challenges to global agriculture, with elevated atmospheric CO2 (eCO₂) concentrations and increased frequency of droughts affecting crop productivity. …”

Data Sheet 4_Cell wall modulation by drought and elevated CO2 in sugarcane leaves.xlsx by Alexandre Junio Borges Araujo (12977867)

“…<p>Climate change poses significant challenges to global agriculture, with elevated atmospheric CO2 (eCO₂) concentrations and increased frequency of droughts affecting crop productivity. …”