Data Sheet 1_Immune monitoring of trabectedin therapy in refractory soft tissue sarcoma patients - the IMMUNYON study.pdf by Paulo Rodrigues-Santos (3424613)

“…Standard treatments include surgical resection and therapies such as anthracyclines or trabectedin for advanced cases, though challenges persist due to the tumor microenvironment’s complexity and limited immune profiling data. …”

Experimental and Numerical Investigations of Soot Formation in the Laminar to Turbulent Transition of an Acetylene Diffusion Flame by Shijun Chen (835302)

“…Soot formation from incomplete hydrocarbon combustion poses significant challenges for emission control in propulsion systems. …”

Image 3_Age-period-cohort analysis of syphilis epidemics in Eastern China, China, 2005–2024.jpeg by Zheyuan Ding (4281394)

“…Background<p>Syphilis remains one of the serious public health challenges in China and worldwide. This study aims to assess the potential independent risks associated with age, period, and birth cohort for the reported incidence of syphilis in Eastern China.…”

Image 2_Age-period-cohort analysis of syphilis epidemics in Eastern China, China, 2005–2024.jpeg by Zheyuan Ding (4281394)

“…Background<p>Syphilis remains one of the serious public health challenges in China and worldwide. This study aims to assess the potential independent risks associated with age, period, and birth cohort for the reported incidence of syphilis in Eastern China.…”

Table 6_Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo stroke.xls by Ahmet Alptekin (14937405)

“…Targeted delivery of IV-administered exosomes has been a significant challenge. Delivery of exosomes to the brain is a daunting task, and a blood–brain barrier (BBB)-penetrable peptide is being considered. …”

Table 4_Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo stroke.xls by Ahmet Alptekin (14937405)

“…Targeted delivery of IV-administered exosomes has been a significant challenge. Delivery of exosomes to the brain is a daunting task, and a blood–brain barrier (BBB)-penetrable peptide is being considered. …”

Supplementary file 1_Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo stroke.pdf by Ahmet Alptekin (14937405)

“…Targeted delivery of IV-administered exosomes has been a significant challenge. Delivery of exosomes to the brain is a daunting task, and a blood–brain barrier (BBB)-penetrable peptide is being considered. …”

Table 3_Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo stroke.xlsx by Ahmet Alptekin (14937405)

“…Targeted delivery of IV-administered exosomes has been a significant challenge. Delivery of exosomes to the brain is a daunting task, and a blood–brain barrier (BBB)-penetrable peptide is being considered. …”

Table 1_Decadal trends and regional disparities in tuberculosis burden: a comprehensive analysis of global, African, and Southeast Asian data from the GBD 1990–2021.docx by Shiwei Xie (3617159)

“…The annual percentage change (APC) was calculated to assess the significance of temporal trends.</p>Results<p>From 1990 to 2021, global age-standardized rates of TB declined markedly, with ASIR decreasing from 173.0 to 103.0 per 100,000, ASMR from 40.0 to 14.0, and ASDR from 1,650.6 to 580.3. …”

Table 2_Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo stroke.xls by Ahmet Alptekin (14937405)

“…Targeted delivery of IV-administered exosomes has been a significant challenge. Delivery of exosomes to the brain is a daunting task, and a blood–brain barrier (BBB)-penetrable peptide is being considered. …”

Data Sheet 1_Analysis of temporal and spatial changes in the global burden of hypertensive heart disease based on data from the Global Burden of Disease study database and future p... by Guoliang Gao (2910503)

“…According to the APC model, the worldwide incidence of hypertensive heart disease is expected to increase from 2022 to 2046, with further decreases in deaths and DALYs.</p>Conclusions<p>This study systematically reveals the increasing trend in the incidence of hypertensive heart disease globally between 1990 and 2021 and confirms the significant impact of sex and socioeconomic development level on its burden. …”

Table 1_Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo stroke.xls by Ahmet Alptekin (14937405)

“…Targeted delivery of IV-administered exosomes has been a significant challenge. Delivery of exosomes to the brain is a daunting task, and a blood–brain barrier (BBB)-penetrable peptide is being considered. …”

Table 5_Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo stroke.xlsx by Ahmet Alptekin (14937405)

“…Targeted delivery of IV-administered exosomes has been a significant challenge. Delivery of exosomes to the brain is a daunting task, and a blood–brain barrier (BBB)-penetrable peptide is being considered. …”

Image 3_IL-33 signaling is dispensable for the IL-10-induced enhancement of mast cell responses during food allergy.jpeg by Dylan Krajewski (5881880)

“…IL-10-depleted WT mice exhibited a significant attenuation in MC-mediated responses to OVA challenge. …”

DataSheet3_Dysregulation of the 3β-hydroxysteroid dehydrogenase type 2 enzyme and steroid hormone biosynthesis in chronic kidney disease.xlsx by Yiyi Zuo (19945293)

“…</p>Results<p>Metabolic characteristics revealed significant shifts in CKD, with 61 metabolites increased and 65 metabolites decreased, highlighting the disruption in steroid hormone biosynthesis pathways influenced by HSD3B2. …”

Image8_Integrating anoikis and ErbB signaling insights with machine learning and single-cell analysis for predicting prognosis and immune-targeted therapy outcomes in hepatocellula... by Huipeng Fang (12587509)

“…Background<p>Hepatocellular carcinoma (HCC) poses a significant global health challenge due to its poor prognosis and limited therapeutic modalities. …”

Image9_Integrating anoikis and ErbB signaling insights with machine learning and single-cell analysis for predicting prognosis and immune-targeted therapy outcomes in hepatocellula... by Huipeng Fang (12587509)

“…Background<p>Hepatocellular carcinoma (HCC) poses a significant global health challenge due to its poor prognosis and limited therapeutic modalities. …”

Data Sheet 1_Synergistic effects of Candida albicans and Porphyromonas gingivalis biofilms on epithelial barrier function in a 3D aspiration pneumonia model.pdf by Ewelina Wronowska (20555480)

“…Introduction<p>Polymicrobial infections involving Candida albicans and Porphyromonas gingivalis represent a significant challenge in maintaining epithelial barrier integrity. …”

Image4_Integrating anoikis and ErbB signaling insights with machine learning and single-cell analysis for predicting prognosis and immune-targeted therapy outcomes in hepatocellula... by Huipeng Fang (12587509)

“…Background<p>Hepatocellular carcinoma (HCC) poses a significant global health challenge due to its poor prognosis and limited therapeutic modalities. …”

Image11_Integrating anoikis and ErbB signaling insights with machine learning and single-cell analysis for predicting prognosis and immune-targeted therapy outcomes in hepatocellul... by Huipeng Fang (12587509)

“…Background<p>Hepatocellular carcinoma (HCC) poses a significant global health challenge due to its poor prognosis and limited therapeutic modalities. …”