Table 1_The ultrafine powder of atractylodis macrocephalae rhizoma improves immune function in naturally aging rats by regulating the PI3K/Akt/NF-κB signaling pathway.xlsx by Wang Yu (8537490)

“…Background<p>The phenomenon of population aging presents a significant global challenge, with the aging population in China steadily increasing. …”

Table 1_Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequenc... by Yueling Peng (20877587)

“…Background<p>Renal fibrosis, characterized by the abnormal accumulation of extracellular matrix in renal tissue and progressive loss of kidney function, is posing a significant challenge in clinical treatment. While several therapeutic options exist, effective treatments remain limited. …”

Table 3_The ultrafine powder of atractylodis macrocephalae rhizoma improves immune function in naturally aging rats by regulating the PI3K/Akt/NF-κB signaling pathway.xlsx by Wang Yu (8537490)

“…Background<p>The phenomenon of population aging presents a significant global challenge, with the aging population in China steadily increasing. …”

Supplementary file 2_Quantile regression application to identify key determinants of malnutrition in five West African countries of Gabon, Gambia, Liberia, Mauritania, and Nigeria.... by Reshav Beni (21422981)

“…Background<p>Malnutrition remains one of the most pressing health challenges, particularly in developing nations across Africa, placing a significant burden on both public health agencies and the affected countries. …”

Supplementary file 1_Quantile regression application to identify key determinants of malnutrition in five West African countries of Gabon, Gambia, Liberia, Mauritania, and Nigeria.... by Reshav Beni (21422981)

“…Background<p>Malnutrition remains one of the most pressing health challenges, particularly in developing nations across Africa, placing a significant burden on both public health agencies and the affected countries. …”

Data Sheet 2_CD44 knockdown alters miRNA expression and their target genes in colon cancer.pdf by Diana Maltseva (11678641)

“…Introduction<p>Metastasis formation poses a significant challenge to oncologists, as it severely limits the survival of colorectal cancer (CRC) patients. …”

Data Sheet 1_CD19+ B cell depletion: a novel strategy to alleviate ischemic stroke damage.pdf by Yu Xu (52257)

“…Background<p>Ischemic stroke, accounting for approximately 80% of all stroke cases, is a major public health challenge and a leading cause of death and disability worldwide. …”

Data Sheet 4_CD44 knockdown alters miRNA expression and their target genes in colon cancer.pdf by Diana Maltseva (11678641)

“…Introduction<p>Metastasis formation poses a significant challenge to oncologists, as it severely limits the survival of colorectal cancer (CRC) patients. …”

Data Sheet 5_CD44 knockdown alters miRNA expression and their target genes in colon cancer.zip by Diana Maltseva (11678641)

“…Introduction<p>Metastasis formation poses a significant challenge to oncologists, as it severely limits the survival of colorectal cancer (CRC) patients. …”

Table 1_An alternative structured weight management protocol to rapid weight loss in mixed martial arts: a prospective interventional study of pre-competition weight management str... by Clóvis Albuquerque Maurício (22389121)

“…For MMA athletes, adhering to an evidence-based Weight Management Protocol (WMP), targeting a 10% body weight reduction within 7 days prior to weigh-in, poses a significant challenge. This study evaluated the efficacy and safety of a structured nutritional strategy, including controlled dietary interventions and fluid manipulation, tailored for athletes seeking to lose 10% of body mass, along with evidence-based recommendations for post-weigh-in recovery. …”

CLAD_sequence_files by Ryan Hunter (21714311)

“…Despite improvements in short-term survival after LT, chronic lung allograft dysfunction (CLAD) remains a critical challenge for long-term survival. This study investigates the relationship between the metabolome of bronchoalveolar lavage fluid (BALF) from subjects post-LT with underlying lung disease and CLAD severity.…”

Data Sheet 1_IL-10 to lymphocyte ratio (ILR) and lactate in the prognosis prediction and risk stratification of sepsis: a pilot study.docx by Yuan Yan (1501603)

“…Background<p>Sepsis is a highly heterogeneous clinical syndrome, and the real-time prognosis prediction and risk stratification for it remain a big challenge in current clinical research. This study aimed to assess the performance of IL-10/lymphocyte ratio (ILR) and lactate (Lac) in the prognostic prediction and risk stratification of sepsis.…”

Data Sheet 1_Post-COVID syndrome patients show reduced anti-Spike antibodies compared to COVID-recovered controls, but enhanced IgG4/IgG1 switch after the third vaccine dose.pdf by Nineth Rossi (22355524)

“…Introduction<p>Long COVID and post-COVID syndromes represent a significant global health crisis and a substantial societal challenge. …”

<i>Tmprss6</i> modulates radiation-induced liver injury through the hepcidin axis and PI3K/AKT pathway by Ya-Li Zhou (21696911)

“…<p>Radiation-induced liver injury (RILI) poses a significant challenge in abdomino-pelvic tumor radiotherapy, adversely impacting normal liver tissues. …”

Supplementary file 1_Therapeutic efficacy and safety of Xuebijing in traumatic brain injury: systematic review and meta-analysis.docx by Yihan Sun (3432287)

“…Background<p>Traumatic brain injury (TBI) represents a major global health challenge. Several clinical studies have suggested that Xuebijing (XBJ)—a patented Chinese botanical drug preparation may confer neuroprotective and anti-inflammatory benefits in TBI. …”

Data Sheet 1_CD44 knockdown alters miRNA expression and their target genes in colon cancer.pdf by Diana Maltseva (11678641)

“…Introduction<p>Metastasis formation poses a significant challenge to oncologists, as it severely limits the survival of colorectal cancer (CRC) patients. …”

Data Sheet 1_An alternative structured weight management protocol to rapid weight loss in mixed martial arts: a prospective interventional study of pre-competition weight managemen... by Clóvis Albuquerque Maurício (22389121)

“…For MMA athletes, adhering to an evidence-based Weight Management Protocol (WMP), targeting a 10% body weight reduction within 7 days prior to weigh-in, poses a significant challenge. This study evaluated the efficacy and safety of a structured nutritional strategy, including controlled dietary interventions and fluid manipulation, tailored for athletes seeking to lose 10% of body mass, along with evidence-based recommendations for post-weigh-in recovery. …”

Data Sheet 1_The CD38+HLA-DR+ T cells with activation and exhaustion characteristics as predictors of severity and mortality in COVID-19 patients.docx by Qiuyue Long (11381148)

“…Background<p>The COVID-19 pandemic remains a global health challenge. Severe cases often respond poorly to standard treatments, highlighting the necessity for novel therapeutic targets and early predictive biomarkers.…”

Table 1_Global, regional, and national anemia burden among women of reproductive age (15–49 years) from 1990 to 2021: an analysis of the Global Burden of Disease Study 2021.docx by Wenshuai Zheng (21641225)

“…Background<p>Anemia remains a significant global health challenge, disproportionately affecting women of reproductive age (WRA, 15 to 49 years) due to physiological and socioeconomic factors. …”

Data Sheet 1_Antiviral therapy can effectively suppress irAEs in HBV positive hepatocellular carcinoma treated with ICIs: validation based on multi machine learning.zip by Shuxian Pan (8868356)

“…However, Immunotherapy-related adverse reactions are still a major challenge faced by tumor immunotherapy, so it is urgent to establish new methods to effectively predict immunotherapy-related adverse reactions.…”