Multi-omics revealed GOT1/ALDH3A1 pathway attenuated head and neck squamous cell carcinoma and increased cisplatin sensitivity through ROS induced by mitochondrial dysfunction by Zhihui Liu (95891)

“…Given that mitochondria are the primary source of reactive oxygen species (ROS), we assessed cellular ROS and mitochondrial superoxide levels by flow cytometry and found a significant increase. GOT1 knockdown increased the sensitivity of cells to cisplatin and decreased the volume of tumors in vivo. …”

Modulation of performance during learning. by Daniel Ramandi (10047543)

“…The ‘W_exp’ value shows the weight of the exponential component in each distribution. (B) A longitudinal comparison of the average exponential fit weight between WT and zQ175 mice reveals that while WT mice show a decreasing trend, indicating a shift towards longer duration (“timed”) trials, zQ175 mice maintain a consistently high exponential weight, demonstrating no significant change over time (b; RM two-way ANOVA, genotype p = 0.0106 F(1, 22) = 7.795, days p < 0.0001 F(5.262, 115.4) = 7.616, interaction p < 0.0001 F(57, 1250) = 2.834). …”

Raw data. by An-Xia Deng (22386214)

“…<div><p>This study evaluated the effectiveness of non-invasive ultrasound technology in monitoring pulmonary edema in a mouse model of acute lung injury (ALI). Male C57BL/6J mice were instilled through the trachea with lipopolysaccharide (LPS, 5 mg/kg, single dose) to induce ALI. …”

Mechanism of action of the 3-nitropyridine compounds. by Jean Herman (109061)

Zika virus replicates efficiently in the zebrafish model and induces morphological defects. by Aïssatou Aïcha Sow (20371233)

“…This schematic was created with <a href="http://BioRender.com" target="_blank">BioRender.com</a>. …”

Glucagon-like peptide-1 receptor agonists, inflammation, and kidney diseases: evidence from Mendelian randomization by Yu-Xuan Yao (21338594)

“…</p> <p>After meta-analyses of both discovery and validation cohorts, genetically proxied GLP1R agonist was found to significantly associated with a decreased risk of diabetic nephropathy (OR = 0.72, 95%CI = 0.54–0.97, <i>p</i> = 0.031) and IgA nephropathy (OR = 0.58, 95%CI = 0.36–0.94, <i>p</i> = 0.027). …”

FFD – main effect, original fibrosis burden. by Åshild Telle (22794721)

DataSheet1_Apolipoprotein A-I attenuates peritoneal fibrosis associated with peritoneal dialysis by inhibiting oxidative stress and inflammation.ZIP by Jing Lu (120666)

“…Yet little is known about apoA-I ’s role in peritoneal dialysis. In this study, by analyzing PD patients (n = 81), we found that decreased apoA/HDL-C ratio is significantly associated with rapid decline in peritoneal function. …”

Therapeutic efficacy of Clrn1 re-expression in Müller glia depends on expression level. by Hannah J. T. Nonarath (20861735)

“…<p>(a) Retinal images of 7 dpf wild-type (upper rows) and <i>clrn1</i>^<i>-/-</i> mutant (lower rows) zebrafish expressing different transgenes (column labels) raised in control lighting conditions (right) or treated from 5-7 dpf with 3500 lux for 48 hours (left, light stress). …”

Operation framework of the SLSM mode. by Yichen Yin (6649409)

“…The application of the SLSM mode to a private machinery manufacturing company in Wenzhou resulted in the effective shouldering of safety responsibilities by the company, a year-on-year decrease in accident rates, and a significant increase in production efficiency, thereby providing corporate managers with guidance and suggestions for making improvements.…”

SLSM fishbone diagram. by Yichen Yin (6649409)

“…The application of the SLSM mode to a private machinery manufacturing company in Wenzhou resulted in the effective shouldering of safety responsibilities by the company, a year-on-year decrease in accident rates, and a significant increase in production efficiency, thereby providing corporate managers with guidance and suggestions for making improvements.…”

Theoretical framework of the lean cost module. by Yichen Yin (6649409)

“…The application of the SLSM mode to a private machinery manufacturing company in Wenzhou resulted in the effective shouldering of safety responsibilities by the company, a year-on-year decrease in accident rates, and a significant increase in production efficiency, thereby providing corporate managers with guidance and suggestions for making improvements.…”

Theoretical framework of the lean safety module. by Yichen Yin (6649409)

“…The application of the SLSM mode to a private machinery manufacturing company in Wenzhou resulted in the effective shouldering of safety responsibilities by the company, a year-on-year decrease in accident rates, and a significant increase in production efficiency, thereby providing corporate managers with guidance and suggestions for making improvements.…”

This figure illustrates the impact of <i>Lactobacillus reuteri</i> supplementation on cytokine concentrations in a mouse model of colitis induced by dextran sulfate sodium (DSS). by Mohsen Nazari (6299819)

“…<p><b>(A)</b> Tumor necrosis factor-alpha (TNF-α): Pro-inflammatory cytokine levels were significantly elevated in the DSS group but were notably reduced in the group treated with <i>L. reuteri</i>. …”

The incidence of grooming is most influenced by the addition of an opaque divider, as compared to manipulanda. by Matthew D. Boulanger (22600966)

Reduced AADT percentage. by Kevin Christiansen (19803541)

“…<div><p>Wildfire-caused damage to highways has a significant financial cost to the local, regional, and state jurisdictions where they occur. …”

Oregon megafires 2015. by Kevin Christiansen (19803541)

“…<div><p>Wildfire-caused damage to highways has a significant financial cost to the local, regional, and state jurisdictions where they occur. …”

AADT 2015–2019 vs. AADT 2020 in Oregon. by Kevin Christiansen (19803541)

“…<div><p>Wildfire-caused damage to highways has a significant financial cost to the local, regional, and state jurisdictions where they occur. …”

Study area summary. by Kevin Christiansen (19803541)

“…<div><p>Wildfire-caused damage to highways has a significant financial cost to the local, regional, and state jurisdictions where they occur. …”

CTCs images obtained with CellSearch. by Romina Mastronicola (20978464)

“…In addition, results of the rate of CTCs helped identify this as an indicator of a prognosis for the patient. Indeed, the study revealed that most patients in remission exhibited a decrease in post-operative CTCs, whereas patients experiencing relapses demonstrated an increase in CTCs, which was correlated with a poor prognosis.…”