Tax1bp1-deficiency reduces autophagy flux. by Jeffrey Chin (22538086)

“…Unexpectedly, we found that Tax1bp1-deficient mice were less susceptible to <i>Mtb</i> infection, and generated reduced inflammatory cytokine responses, compared to wild-type mice; the same mutant mice exhibited decreased growth of, and inflammatory cytokine responses to, <i>Listeria monocytogenes</i>, suggesting that Tax1bp1 plays a role in host responses to multiple intracellular pathogens. …”

Relationship between purposeful rumination and post-traumatic growth of college students who experienced childhood trauma: a regulated intermediary model Checklist by Sanglin Zhao (20599835)

“…Results: Correlation analysis showed that purposive rumination, positive coping and post-traumatic growth were significantly correlated. Regression analysis showed that purposive rumination had a significant direct effect on post-traumatic growth (β=0.148, P<0.001) . …”

Table 1_Regional high iron deposition is linked with cognitive impairments in peritoneal dialysis: a quantitative susceptibility mapping study.doc by Dashan Li (1688155)

“…Every 100 μg/L increase in SF beyond this threshold was associated with a 3.1-point decrease in MoCA score. Iron deposition in the left amygdala showed significant correlations with scores on the Digit Symbol Test (DST), Self-Rating Depression Scale (SDS), Self-Rating Anxiety Scale (SAS), and Verbal Fluency Test (VFT), but exhibited no direct association with peripheral iron metabolism parameters.…”

Data Sheet 1_The role of statins in dementia or Alzheimer’s disease incidence: a systematic review and meta-analysis of cohort studies.docx by Ye Du (4067569)

“…Similarly, an analysis of 19 studies comprising 1,237,341 participants demonstrated a 29% decrease in the risk of AD among statin users (HR: 0.71, 95% CI: 0.60–0.85). …”

Table 2_Quantitative evaluation of IVL: based on the tunica media gypsum calcification model and a prospective animal study.doc by Zongwei Liu (3133743)

Table 1_Quantitative evaluation of IVL: based on the tunica media gypsum calcification model and a prospective animal study.doc by Zongwei Liu (3133743)

Supplementary Material for: Construction of a hybrid vaccine based on Der f 35-derived peptides with reduced allergenicity by Hu H. (4145581)

“…The IgE-ELISA revealed a significant reduction in IgE-binding activity to the vaccine when compared to wild-type Der f 35 (p < 0.0001), the decreased allergenicity were further confirmed by IgE-Western blot, inhibition ELISA and BAT, respectively. …”

Supplementary Material for: How the COVID-19 Pandemic Impacted Neurological Hospital Admissions in Germany - A Retrospective Analysis by figshare admin karger (2628495)

“…While overall admissions decreased, average case severity was significantly higher. …”

Table 1_Cholesterol metabolic reprogramming drives the onset of DLBCL and represents a promising therapeutic target.docx by Lili Zhou (265076)

“…</p>Results<p>We confirmed significant alterations in metabolic markers (such as TC and ApoA1) between the healthy control group and patients, which were significantly associated with patient prognosis and overall OS. …”

Supplementary file 1_Indirect regeneration of long-term callus cultures in gladiolus: a protocol for stable genetic fidelity.docx by Seyedehraziyeh Mousavimatin (21398525)

“…This medium led to an 80% decrease in the accumulation of phenolic compounds across all cultivars in comparison to the control. …”

Image_1_The causal effects of dietary component intake and blood metabolites on risk of delirium: a Mendelian randomization study.pdf by Qian Zhu (191342)

Table_1_The causal effects of dietary component intake and blood metabolites on risk of delirium: a Mendelian randomization study.xlsx by Qian Zhu (191342)

Supplementary Material for: Does manual acupuncture improve gastro-esophageal reflux disease symptoms? A trial sequential meta-analysis by figshare admin karger (2628495)

DataSheet2_Chitinase 1: a novel therapeutic target in metabolic dysfunction-associated steatohepatitis.docx by Jung Hoon Cha (19723588)

“…</p>Conclusions<p>Our study underscores the pivotal role of CHIT1 in MASH. The observed significant improvement in inflammation and hepatic fibrosis, particularly at higher doses of the CHIT1 inhibitor, strongly suggests the potential of CHIT1 as a therapeutic target in MASH accompanied by progressive liver fibrosis.…”

DataSheet1_Chitinase 1: a novel therapeutic target in metabolic dysfunction-associated steatohepatitis.zip by Jung Hoon Cha (19723588)

“…</p>Conclusions<p>Our study underscores the pivotal role of CHIT1 in MASH. The observed significant improvement in inflammation and hepatic fibrosis, particularly at higher doses of the CHIT1 inhibitor, strongly suggests the potential of CHIT1 as a therapeutic target in MASH accompanied by progressive liver fibrosis.…”

Data Sheet 1_Microbial dysbiosis in obstructive sleep apnea: a systematic review and meta-analysis.docx by Yang Guo (399435)

“…Furthermore, in comparison to the non-OSA individuals, the gut environment of patients with OSA exhibited an increased relative abundance of phylum Firmicutes, along with elevated levels of genera Lachnospira; conversely, there was a decreased relative abundance of phylum Bacteroidetes and genus Ruminococcus and Faecalibacterium. …”

Effect of the strategy game Mangala on cognitive function, anxiety, depression, and fine motor skills in individuals with Alzheimer’s disease: A randomized controlled trial by Aziz Dengiz (20494793)

“…<p>Cognitive impairment, changes in mood, and decrease in fine motor skills are some of the most common symptoms experienced by individuals with Alzheimer’s Disease (AD). …”

Raw data for Figs 1, 2, 3, 4 and S2. by Areej A. Alfaifi (20422411)

“…Bulk RNA-sequencing of parotid salivary glands from COVID-19 autopsies demonstrated statistically significant decreased expression of histatin and amylase genes. …”

Data Sheet 1_Plasma testosterone concentration is correlated with circulating immune cell abundance in transgender young people on gender-affirming hormone treatment.pdf by Alice A. White (21695726)

“…Differences in the abundance of other T cell subsets were detected in both trans males and trans females, however only a decrease in CD161⁺ T effector memory cells in trans males, compared to control females, was associated with lower testosterone levels. …”

Engineered deletions of 1-TbAd biosynthesis genes reveal gene functions and greatly expand the lipid signature. by Jacob A. Mayfield (19762468)

“…(B) Area-under-the-curve of extracted ion chromatograms tested 1-TbAd production by the parental Mtb strain (H37Rv) and single or two-gene knockouts as well as the <i>Rv3378c</i> deletion complemented with <i>Rv3378c</i>. A Benjamini–Hochberg adjusted <i>p</i> value is indicated only for significant pairwise <i>t</i> tests (*: <i>p</i> < 0.05, **: <i>p</i> < 0.01, ***: <i>p</i> < 0.001, ****: <i>p</i> < 0.0001). …”