Image 1_Immunomodulatory effects of probiotic Lactobacillus brevis ZG2488 on SARS-CoV-2 vaccine responses in mice.tif by Mengshan Chen (14303892)

“…Transcriptomic analysis revealed upregulation of the JAK-STAT signaling pathway, antigen processing and presentation pathways, and pro-inflammatory pathways (IL-17/TNF/NLR/PI3K-Akt), alongside downregulation of hyperinflammation-associated pathways. CIBERSORT analysis showed that ZG2488 reshaped splenic immune cell composition, increasing memory CD4⁺ T cells, Th1 cells, and dendritic cells (DCs), while decreasing macrophages, follicular helper T (Tfh) cells, monocytes, and γδ T cells.…”

Supplementary file 1_The gut commensal Faecalibacterium hominis attenuates indole—AhR signaling and restores ASD—like behaviors with BTBR mice.docx by You Yu (2102071)

“…<p>Autism spectrum disorders (ASD), a group of neurodevelopmental disorders characterized by the core symptoms of impaired social communication and stereotyped behaviors, is strongly associated with dysregulated microbiota-gut-brain axis. …”

Data Sheet 11_Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective.pdf by Didar Murad (12220805)

“…We explored that the decreased levels of complement factor H and C1-inhibitor significantly elevate these components, whereas tissue factor pathway inhibitor and alpha-2-macroglobulin have more modest effects. …”

Table 1_The health burden of disease attributable to low calcium intake: a comprehensive analysis of trends and socioeconomic impacts from 1990 to 2021.docx by Yanping Wang (275956)

“…Prostate cancer and DLC showed a negative directional trend but lacked statistical significance. CRC burden showed a negative correlation with SDI, while prostate cancer burden had a positive association.…”

Table 1_Therapeutic potential of Triptolide in inhibiting breast cancer-induced bone destruction – PTHrP as a therapeutic target.docx by Wu Di (11561998)

“…Introduction<p>Bone metastases are a common and severe complication in advanced breast cancer, affecting approximately 65% to 70% of patients and significantly reducing survival time. Osteolytic bone metastases, in particular, are challenging to manage due to their association with skeletal-related events (SREs) that accelerate disease progression and diminish the quality of life. …”

Supplementary Material for: Impairment of Renal Function in Hermansky-Pudlak Syndrome by Yokoyama T. (4606381)

“…The genetic types of HPS are associated with a spectrum of multisystemic clinical manifestations. …”

Data Sheet 1_Predict and prevent microvascular complications of type 2 diabetes: a cross-sectional and longitudinal study in Chinese communities.docx by Zhaoxiang Liu (9019424)

“…XGBoost identified that diabetes duration, age, HbA1c, FBG, triglyceride, BP, serum creatinine, proteinuria, aspirin and statin use were associated with those microvascular complications. The risk of DKD increased more rapidly as HbA1c exceeded 7.5% and decreased as blood pressure was maintained below 120/70 mmHg. …”

Table1_Gut microbiota and metabolomics unveil the mechanisms of Lomatogonium rotatum in ameliorating visceral fat and serum lipids in high-fat diet-induced obese mice.XLSX by Xiaoping Ji (531042)

“…In this study, we assessed the alterations of LR on gut microbes and serum metabolites in obese mice and their associated mechanisms of modulation on visceral fat and serum lipid by integrating gut microbiota and metabolomics analyses. …”

Data Sheet 1_Metastatic organ count stratifies survival in immunotherapy-treated metastatic colorectal cancer: a retrospective cohort study.docx by Hai-Yan Fu (1586935)

“…</p>Conclusions<p>Increased metastatic organ count in patients with mCRC was associated with decreased immunotherapy ORR and worse prognosis, with a particularly pronounced effect observed in patients with lung metastasis.…”

Data Sheet 1_IgE autoantibodies to nuclear antigens in patients with different connective tissue diseases: re-evaluation and novel findings.docx by Kathrin Kramer (20906207)

“…In MCTD, there was an association of anti-Sm/RNP B and -RNP68 antibodies with pulmonary disorder.…”

Data Sheet 1_N-acetylcysteine reduces prefrontal reactivity to cocaine cues in individuals with cocaine use disorder.pdf by Etna J. E. Engeli (20793524)

“…Background<p>Individuals with cocaine use disorder experience heightened motivation to pursue rewards tied to cocaine, often triggered by associated cues. Cue reactivity and subsequent craving significantly elevate the risk of substance use, creating a pressing need for treatments that can help alleviate cravings. …”

Data Sheet 1_Susceptibility to and severity of tuberculosis infection in mice depends upon MHC-II-determined level of activation-inhibition balance in CD4 T-cells.pdf by Nadezhda Logunova (831700)

“…Second, during a few months post challenge, B6 mice were able to control both the size of the IFN-γ-producing CD4⁺ T-cell population and the total proportion of activated CD4⁺ T-cells at levels significantly lower than those in B6.I-9.3 mice. Finally, in TB-susceptible mice, a higher proportion of CD4⁺ T-cells expressed both activation-associated and immune inhibition (checkpoint) markers, accompanied by functional CD4⁺ T-cell exhaustion at late stages of infection. …”

Table 1_Plant-based diets and total and cause-specific mortality: a meta-analysis of prospective studies.docx by Qiwang Mo (9091292)

“…Participants in the highest quintile of both the PDI and hPDI had a significantly decreased risk of all-cause mortality (pooled HR_PDI = 0.85; 95% CI: 0.80–0.90; pooled HR_hPDI = 0.86; 95% CI: 0.81–0.92) compared to participants in the lowest quintile. …”

Image 2_Plant-based diets and total and cause-specific mortality: a meta-analysis of prospective studies.tif by Qiwang Mo (9091292)

“…Participants in the highest quintile of both the PDI and hPDI had a significantly decreased risk of all-cause mortality (pooled HR_PDI = 0.85; 95% CI: 0.80–0.90; pooled HR_hPDI = 0.86; 95% CI: 0.81–0.92) compared to participants in the lowest quintile. …”

Image 1_Plant-based diets and total and cause-specific mortality: a meta-analysis of prospective studies.tif by Qiwang Mo (9091292)

“…Participants in the highest quintile of both the PDI and hPDI had a significantly decreased risk of all-cause mortality (pooled HR_PDI = 0.85; 95% CI: 0.80–0.90; pooled HR_hPDI = 0.86; 95% CI: 0.81–0.92) compared to participants in the lowest quintile. …”

Data_Sheet_1_miR-124 Alleviates Ischemic Stroke-Induced Neuronal Death by Targeting DAPK1 in Mice.docx by Yan Shi (166398)

“…</p>Results<p>In vivo and in vitro results demonstrated that levels of miR-124 were significantly decreased following stroke, whereas changes in death-associated protein kinase 1 (DAPK1) levels exhibited the converse pattern. …”

Data Sheet 1_DNase I alleviates renal inflammatory injury in MRL/lpr mice by inhibiting NETs formation.docx by Manling Zhang (566460)

“…Notably, neutrophil extracellular traps (NETs) formation has been closely associated with renal inflammatory injury. However, the underlying pathophysiological mechanisms remain incompletely understood.…”

Table 1_Autophagy crosstalk with the immune microenvironment in chronic myeloid leukemia and serves as a biomarker for diagnosis and progression.xlsx by Fangmin Zhong (17415318)

“…Low autophagy scores are also associated with malignant progression and nonresponse to treatment. …”

Table 1_DNase I alleviates renal inflammatory injury in MRL/lpr mice by inhibiting NETs formation.docx by Manling Zhang (566460)

“…Notably, neutrophil extracellular traps (NETs) formation has been closely associated with renal inflammatory injury. However, the underlying pathophysiological mechanisms remain incompletely understood.…”

Image 1_Down-regulation of colon mucin production induced by Eimeria pragensis infection in mice.tiff by Yulia Dwi Setia (21590591)

“…Maximal parasite accumulation in the proximal colon was observed at 8 dpi in histological examination as well as qPCR. Colon length was significantly shortened at 3 dpi. Goblet cell area significantly reduced at 8 dpi (p < 0.05). …”