Supplementary file 1_Comprehensive real-time metabolic profiling of peripheral blood mononuclear cells reveals important methodological considerations for immunometabolism research... by Michael Macleod (22516823)

“…Extended blood processing time significantly lowered T cell activation capacity in PBMCs, evidenced by decreased responses of mitochondrial and glycolytic ATP supply to CD3/CD28 activation.…”

<b>Seasonal Hydrology and Projected Landscape Changes Jointly Shape Future Water Quality in a Typical Watershed of the Three Gorges Reservoir Area</b> by Xiaojun Zhao (22390147)

“…Under future scenarios of aggravated landscape fragmentation, TN concentrations decreased while TOC and COD_Mn concentrations significantly increased compared to the 2024 dry season. …”

Image 4_PRP pre-treatment of the implantation zone improves the survival rate of fat autograft.jpeg by Ilona Pak (21074279)

“…</p>Discussion<p>We have demonstrated that the pre-implantation use of platelet-rich plasma significantly improves the standard intraoperative technique and increases the survival rate of the fat autograft by enhancing angiogenesis, with a decreased degree of hypoxic-ischemic, fibrotic, and inflammatory damage in the implant area.…”

Image 4_SarZ inhibits the hemolytic activity through regulation of phenol soluble modulins in Staphylococcus epidermidis.jpeg by Xiao Chen (260187)

“…The sarZ psmβ double mutant was further generated and displayed a significantly decreased hemolytic activity compared with the sarZ mutant. …”

Data Sheet 1_Integrative analysis of transcriptome and metabolome reveals molecular mechanisms of dynamic change of storage substances during dehydration and drying process in pean... by Jingjing Deng (468275)

“…S3d was the key period during which the content of most of the metabolites changed significantly. The contents of most amino acids(87%) and their derivatives decreased significantly, and most of the lipids(68%), sugars(67%) and flavonoids(87%) accumulated to their peak at S3d. …”

Table 1_Genome-wide analysis of lncRNA in wheat (Triticum aestivum) and functional characterization of TalncR9 in response to drought stress.xlsx by Lianzhe Wang (6202643)

“…Silencing TalncR9 in wheat reduced drought tolerance, decreased soluble sugar and proline levels, and increasing MDA levels. …”

Table 5_Burden of pulmonary arterial hypertension in children globally, regionally, and nationally (1990–2021): results from the global burden of disease study.docx by Lili Deng (152262)

“…</p>Results<p>The findings indicate a stable prevalence rate globally, with a slight increase in the absolute number of cases. Significantly, reductions were observed in both mortality and disability-adjusted life years (DALYs) associated with pediatric PAH, with mortality decreasing by 57.66% and DALYs by 63.59% over the study period, indicating progress in mitigating the disease burden. …”

Short-term antiretroviral therapy may not correct the dysregulations of plasma virome and cytokines induced by HIV-1 infection by Yingying Ma (3617810)

“…These results suggest that short-term ART may not significantly correct the virome and cytokine dysregulations induced by HIV-1 infection. …”

Data Sheet 1_Lysate of Parabacteroides distasonis prevents severe forms of experimental autoimmune encephalomyelitis by modulating the priming of T cell response.docx by Zuzana Jiraskova Zakostelska (6386825)

“…EAE induction was the main factor in altering the gut microbiota, decreasing the abundance of lactobacilli and segmented filamentous bacteria. …”

Data Sheet 1_Dietary canthaxanthin improves egg production rate through regulating hepatic lipid metabolism and redox status in indigenous chickens.docx by Jie Chen (5892)

“…At week 9, 8 mg/kg CX significantly decreased serum MDA levels (p < 0.05). …”

Supplementary Material for: Hypothyroidism promotes microglia M1 polarization by inhibiting BDNF-promoted PI3K-Akt signaling pathway by Zhan Y. (4157410)

“…In BV2 cells, LPS treatment decreased expression of BDNF, IL-10, and Arg1, while BDNF overexpression (BDNF-OE) significantly reversed the inflammation-induced by LPS by repressing iNOS and TNF-α, while increasing IL-10 and Arg1. …”

Supplementary Material for: High expression of tetraspanin CD63 predicts poor prognosis in esophageal squamous cell carcinoma by Matsumoto Y. (2866151)

“…Herein, we report the significance of CD63 expression by analyzing ESCC patient samples and ESCC cell lines. …”

Image 8_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Molecular features influencing clinical outcome of advanced HER2-positive gastric cancer receiving trastuzumab plus chemotherapy by Yu Lei (266919)

“…Additionally, after treatment, TMB significantly increased in non-responders, while CIN significantly decreased in responders.…”

Table 1_Nanocarrier-mediated RNAi of CYP9E2 and CYB5R enhance susceptibility of invasive tomato pest, Tuta absoluta to cyantraniliprole.docx by Farman Ullah (783297)

“…Notably, nanocarrier-encapsulated dsRNA targeting CYB5R and CYP9E2 genes significantly reduced their expression levels. Further, the activity of cytochrome P450 was substantially decreased after the knockdown of the CYB5R and CYP92 genes. …”

Table 5_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.xlsx by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Supplementary file 1_Effects of human urine application on soil physicochemical properties, microbial communities, and enzymatic activities.docx by Guangquan Yu (21630101)

“…<p>Human urine (HU) is rich in nutrients necessary for plant growth, and recycling HU as fertilizer has multiple positive impacts, such as enhancing agricultural sustainability, reducing wastewater pollution, and decreasing reliance on chemical fertilizers, so it is of great significance to explore the effects of urine agricultural utilization on soil environment. …”

Table 10_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.xlsx by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”

Table 1_Safety and efficacy comparison of single-stage and two-stage ERCP combined with laparoscopic cholecystectomy: a meta-analysis and systematic review.xlsx by Jian-Xiong Tai (22696688)

“…The incidence of pancreatitis was significantly higher in the sequential surgery group compared to LERV (RR = 1.90, 95% CI: 1.61–2.24). …”

Image 3_Spatiotemporal trends of ischemic stroke burden attributable to PM2.5 from 1990 to 2021.pdf by Yunyan Lu (10699005)

“…The age-standardized rates (ASRs) of ischemic stroke linked to ambient PM2.5 slightly declined, while those associated with household PM2.5 significantly decreased over the past 32 years. The burden of ischemic stroke attributable to ambient and household PM2.5 exhibited considerable heterogeneity across 204 countries. …”