Table1_Cytochrome P450 VvCYP76F14 dominates the production of wine bouquet precursors in wine grapes.docx حسب Guangli Xia (19834830)

"…Site-directed mutation of 4 amino acid residues (I120L, L298V, E378G, and T389A) in VvCYP76F14 resulted in a significant decrease in VvCYP76F14 enzymatic activities, respectively. …"

Image1_Cytochrome P450 VvCYP76F14 dominates the production of wine bouquet precursors in wine grapes.tif حسب Guangli Xia (19834830)

"…Site-directed mutation of 4 amino acid residues (I120L, L298V, E378G, and T389A) in VvCYP76F14 resulted in a significant decrease in VvCYP76F14 enzymatic activities, respectively. …"

Table4_Cytochrome P450 VvCYP76F14 dominates the production of wine bouquet precursors in wine grapes.docx حسب Guangli Xia (19834830)

"…Site-directed mutation of 4 amino acid residues (I120L, L298V, E378G, and T389A) in VvCYP76F14 resulted in a significant decrease in VvCYP76F14 enzymatic activities, respectively. …"

Basal HLH-30 activity is not accompanied by enriched nuclear localization and declines during neuronal aging. حسب Ruiling Zhong (22339779)

"…****<i>P</i> < 0.0001, ns: not significant, Fisher’s exact test. <b>(C)</b> The bHLH binding sequence is similar between human TFEB and <i><i>Caenorhabditis elegans</i></i> HLH-30 [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002957#pbio.3002957.ref061" target="_blank">61</a>]. …"

Continuing evolution of H5N1 highly pathogenic avian influenza viruses of clade 2.3.2.1a G2 genotype in domestic poultry of Bangladesh during 2018–2021 حسب Mohammed Nooruzzaman (3175290)

"…In the HA protein of the study isolates, functionally meaningful mutations caused the loss of an N-linked glycosylation site (T156A), a modified antigenic site A (S141P), and a mutation in the receptor binding pocket (E193R/K). Consequently, antigenic analysis revealed a significant loss of cross-reactivity between viruses from different host species and periods. …"

<b>Characterizing the role of PP2AB'' family subunits in mechanical stress response and plant development through calcium and ABA signaling in </b><b><i>Arabidopsis thaliana</i></b... حسب Hyuk Sung Yoon (19985262)

"…Transcriptome analysis showed a significant decrease in the expression of <i>CYP707A3</i>, a gene potentially targeted by VIP1 that regulates abscisic acid (ABA) catabolism, in the <i>atb''αβγδ</i> mutant compared to wild type leaves. …"

DataSheet1_Kinetics of endothelin-1 and effect selective ETA antagonism on ETB activation: a mathematical modeling analysis.docx حسب K. Melissa Hallow (9248960)

"…The drug concentration required to cause a decrease in [ET1-ET_B] was lower as ET_A selectivity decreased.…"

Data Sheet 1_Discovery of N′-(1-(coumarin-3-yl)ethylidene)benzenesulfonohydrazide as a novel wound healing enhancer: synthesis, biological assessment, and molecular modeling.pdf حسب Eman F. Khaleel (4844745)

"…The results indicated that CBSH significantly promotes the migration of skin fibroblast cells and enhances the wound healing process. …"

Data Sheet 1_Schaftoside contributed to anti-inflammatory activity of Clinacanthus nutans extract in lipopolysaccharide-induced RAW 264.7 cells.docx حسب Saruda Thongyim (19372687)

"…</p>Results and Discussion<p>At a concentration of 40 μM, schaftoside significantly downregulated the expression of key inflammation-related genes, including iNOS, COX2, PGE2, PGE4, TNF-α, and IL6. …"

Data Sheet 1_miR-198 targets TOPORS: implications for oral squamous cell carcinoma pathogenesis.pdf حسب Pankhuri Kaushik (20381022)

"…Delivery of a synthetic miR-198 mimic to OSCC cells results in a significant decrease in xenograft size in nude mice, potentiating its use in therapeutics.…"

Supplementary file 1_HuangLian-4 alleviates myocardial ischemia-reperfusion injury by activating the pro-survival STAT3 signaling pathway.doc حسب Chelimuge Gong (22563287)

"…This activation of STAT3 was accompanied by a significant increase in the anti-apoptotic protein Bcl-2 and a decrease in pro-apoptotic Bax, alongside the suppression of the maladaptive factor HIF-1α. …"

DataSheet1_Glioma-associated oncogene homolog 1 in breast invasive carcinoma: a comprehensive bioinformatic analysis and experimental validation.docx حسب Teng Qi (278739)

"…</p>Results<p>The findings reveal dysregulated expression of GLI1 in numerous cancers, with a significant decrease observed in BRCA. High GLI1 expression indicated better survival outcomes and was correlated with the age and stage of BRCA patients. …"

Data Sheet 1_The secreted host-cell protein clusterin interacts with PmpD and promotes Chlamydia trachomatis infection.pdf حسب Fabienne Kocher (20620811)

"…In infection experiments, depletion of sCLU from the culture medium leads to a significant decrease in Ctr infection. Thus, sCLU is the first host-cell interaction partner identified for a Ctr Pmp and the first case in which sCLU has been shown to be a vital component for the establishment of a bacterial infection.…"

Table 5_Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma.docx حسب Bin Liao (714989)

"…Simultaneous knockout of HIF1α and HIF2α in GBM cells resulted in the highest LDH release and apoptosis rates under hypoxic conditions, accompanied by the most significant decrease in IGF1R, p-PDK1, and p-AKT levels. …"

Table 1_Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma.docx حسب Bin Liao (714989)

"…Simultaneous knockout of HIF1α and HIF2α in GBM cells resulted in the highest LDH release and apoptosis rates under hypoxic conditions, accompanied by the most significant decrease in IGF1R, p-PDK1, and p-AKT levels. …"

Table 2_Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma.docx حسب Bin Liao (714989)

"…Simultaneous knockout of HIF1α and HIF2α in GBM cells resulted in the highest LDH release and apoptosis rates under hypoxic conditions, accompanied by the most significant decrease in IGF1R, p-PDK1, and p-AKT levels. …"

Table 4_Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma.docx حسب Bin Liao (714989)

"…Simultaneous knockout of HIF1α and HIF2α in GBM cells resulted in the highest LDH release and apoptosis rates under hypoxic conditions, accompanied by the most significant decrease in IGF1R, p-PDK1, and p-AKT levels. …"

Table 3_Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma.docx حسب Bin Liao (714989)

"…Simultaneous knockout of HIF1α and HIF2α in GBM cells resulted in the highest LDH release and apoptosis rates under hypoxic conditions, accompanied by the most significant decrease in IGF1R, p-PDK1, and p-AKT levels. …"

Table 6_Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma.docx حسب Bin Liao (714989)

"…Simultaneous knockout of HIF1α and HIF2α in GBM cells resulted in the highest LDH release and apoptosis rates under hypoxic conditions, accompanied by the most significant decrease in IGF1R, p-PDK1, and p-AKT levels. …"

Calcium Changes Following a Neighboring Cell Death حسب Sriram Selvakumaran (22386294)

"…</p><p dir="ltr">To investigate the role of purinergic signaling, astrocytes were treated with suramin, a P2 receptor antagonist that blocks ATP binding. The experiment revealed a sharp intracellular calcium spike in astrocytes following adjacent cell death, followed by a sustained decrease below baseline levels. …"