Data Sheet 1_In silico molecular studies of Phosphinogold(I) thiocarbohydrate complexes: insights into multi-target anticancer mechanisms.docx by Alkhair Adam Khalil Mohamed (21529289)

“…While acetylation decreased binding affinity; it enhanced cellular activity as reported in in vitro studies indicative of the need to balance lipophilicity and binding strength in future ligand design.…”

Data Sheet 2_Gut microbiota metabolite acetate mediates free fatty acid receptor 2 expression to alleviate atopic dermatitis.zip by Siqi Ye (9350531)

“…Acetate supplementation in AD mice significantly ameliorated 2,4-dinitrobenzene (DNCB)-induced dermatitis, as evidenced by reduced skin lesion severity, lower dermatitis scores, and decreased epidermal thickening. …”

Data Sheet 1_Gut microbiota metabolite acetate mediates free fatty acid receptor 2 expression to alleviate atopic dermatitis.zip by Siqi Ye (9350531)

“…Acetate supplementation in AD mice significantly ameliorated 2,4-dinitrobenzene (DNCB)-induced dermatitis, as evidenced by reduced skin lesion severity, lower dermatitis scores, and decreased epidermal thickening. …”

Data Sheet 1_Elucidating the mechanism of stigmasterol in acute pancreatitis treatment: insights from network pharmacology and in vitro/in vivo experiments.pdf by Xuanlin Zhao (20466980)

“…Molecular docking analysis further revealed a strong binding capacity of stigmasterol to ERK1 (−6.57 kL/mol). …”

Table 1_Screening and identification of the H1R antagonists from natural products by BODIPY FL histamine recognition and DPHD-anchored bombardment coupled with target cell extracti... by Xinqi Li (14029494)

“…The BODIPY FL histamine recognition results revealed the significant blocking effects on H1R binding by pseudoephedrine (50 μM) and dictamnine (100 μM). …”

Identification of a Novel Virulence Factor in <i>Klebsiella pneumoniae</i> through CpxR-Dependent Transcriptional Activation by Runze Wang (21792959)

“…Among the genes exhibiting significantly decreased expression upon <i>cpxR</i> deletion<i>, </i>we identified a novel potential virulence factor KPHS_28080. …”

Supplementary Material for: Construction of a hybrid vaccine based on Der f 35-derived peptides with reduced allergenicity by Hu H. (4145581)

“…The IgE-ELISA revealed a significant reduction in IgE-binding activity to the vaccine when compared to wild-type Der f 35 (p < 0.0001), the decreased allergenicity were further confirmed by IgE-Western blot, inhibition ELISA and BAT, respectively. …”

Supplemental Figures by Danielle A. Jeffrey (21187329)

“…FXR1 has seven isoforms, including isoforms mostly expressed in skeletal and cardiac tissue, and play a significant role in heart development and function. …”

Table 1_Effects of neutral detergent fiber levels on apparent nutrient digestibility and intestinal microbiota composition and function in forest musk deer.docx by Qindan Dai (11056236)

“…In the CAZy functional analysis, significant differences (p < 0.05) were observed in glycoside hydrolases (GHs) and carbohydrate-binding modules (CBMs), with the M group showing clear enrichment in fiber-degrading enzymes. …”

Data Sheet 1_ZBP1 senses Brucella abortus DNA triggering type I interferon signaling pathway and unfolded protein response activation.pdf by Marco Túlio R. Gomes (5363324)

“…ZBP1 interacts with cytosolic DNA via its DNA-binding domains, crucial for its activation. Brucella abortus is the etiologic agent of brucellosis in livestock and humans, leading to significant economic losses and public health impact. …”

Data Sheet 1_Curcumin promotes spermatogenesis in mice with cryptorchidism by regulating testicular protein O-GlcNAcylation.docx by Zhen Wang (72451)

“…Curcumin treatment mitigated these abnormalities, with the most significant improvement observed at a dosage of 100 mg/kg, without substantial adverse effects on other organs. …”

Table 1_Foxr1 deletion causes microcephaly and leads to cortical and hippocampal hypoplasia.xlsx by Hannah Waxman (21429320)

“…Cortical thinning is primarily driven by a significant reduction in layer 2/3 neurons, linked to impaired generation of later-born neurons. …”

Image 1_Foxr1 deletion causes microcephaly and leads to cortical and hippocampal hypoplasia.tif by Hannah Waxman (21429320)

“…Cortical thinning is primarily driven by a significant reduction in layer 2/3 neurons, linked to impaired generation of later-born neurons. …”

Table 1_Preventive administration of shengmaiyin: a novel approach to counteract heatstroke-induced coagulopathy in rats.xlsx by Longping He (18492915)

“…The EHS group showed significantly prolonged PT and APTT, increased Lac, decreased platelet count, and elevated plasma levels of TM, vWF, TSP-1, and PAI-1 compared to the NC group (P < 0.05). …”

GPCR kinase, <i>Ppa</i>-GRK-2 is required for light avoidance. by Kenichi Nakayama (2354653)

“…<i>Ppa-grk-2</i> mutants had decreased light avoidance. One-way ANOVA, Dunnett’s multiple comparison tests, compared with wild type. n.s = not significant, ***<i>P</i> < 0.001, ****<i>P</i> < 0.0001.…”

Table 1_Evaluation of the safety and efficacy of Sophorae Flavescentis Radix extract in the treatment of inflammatory bowel disease based on zebrafish models.docx by Xiaolu Chen (3801862)

“…Furthermore, Kushen extract treatment at low doses significantly decreased the levels of pro-inflammatory cytokines. …”

S2 Data - by Chelsea A. Simpson (9579303)

“…LuxR G37V has decreased DNA binding activity. (C) Bioluminescence production (light divided by OD₆₀₀) throughout a growth curve for DS40M4 strains. …”

Table 2_Brown adipocyte exosome - derived C22:6 inhibits the IL-1β signaling pathway to alleviate rheumatoid arthritis.docx by Rui Jiang (264894)

“…Introduction<p>Rheumatoid arthritis (RA) is an autoimmune disorder characterized by significant disability and teratogenic effects, for which there are few effective curative therapies. …”

Table 1_Brown adipocyte exosome - derived C22:6 inhibits the IL-1β signaling pathway to alleviate rheumatoid arthritis.docx by Rui Jiang (264894)

“…Introduction<p>Rheumatoid arthritis (RA) is an autoimmune disorder characterized by significant disability and teratogenic effects, for which there are few effective curative therapies. …”

Data Sheet 1_Brown adipocyte exosome - derived C22:6 inhibits the IL-1β signaling pathway to alleviate rheumatoid arthritis.pdf by Rui Jiang (264894)

“…Introduction<p>Rheumatoid arthritis (RA) is an autoimmune disorder characterized by significant disability and teratogenic effects, for which there are few effective curative therapies. …”