يعرض 881 - 900 نتائج من 1,038 نتيجة بحث عن '(( significant decrease decrease ) OR ( significant binding decrease ))~', وقت الاستعلام: 0.40s تنقيح النتائج
  1. 881
  2. 882
  3. 883

    Deciphering the involvement of norepinephrine and β-adrenergic receptor subtypes in glucose induced insulin secretion: an integrated <i>in silico</i> and <i>in vitro</i> exploratio... حسب Vijayalakshmi Gangadhara (20481150)

    منشور في 2024
    "…The nonselective β-AR antagonist propranolol significantly decreased (<i>p</i> < 0.01)insulin secretion, suggesting alternative interactions with β1-AR and β2-AR despite lacking hydrogen bonds. …"
  4. 884

    Table 1_Immunomodulatory peptide–drug conjugate MEL-dKLA suppresses progression of prostate cancer by eliminating M2-like tumor-associated macrophages.docx حسب Ik-Hwan Han (8605281)

    منشور في 2025
    "…In vivo, MEL-dKLA treatment significantly reduced tumor growth, decreased the number of CD163<sup>+</sup> M2 macrophages, and increased CD8<sup>+</sup> T cell infiltration in tumor tissues. …"
  5. 885

    Table 2_Immunomodulatory peptide–drug conjugate MEL-dKLA suppresses progression of prostate cancer by eliminating M2-like tumor-associated macrophages.docx حسب Ik-Hwan Han (8605281)

    منشور في 2025
    "…In vivo, MEL-dKLA treatment significantly reduced tumor growth, decreased the number of CD163<sup>+</sup> M2 macrophages, and increased CD8<sup>+</sup> T cell infiltration in tumor tissues. …"
  6. 886

    Data Sheet 1_New prognostic features and personalized treatment strategies of mitochondrial related genes in colorectal cancer patients.docx حسب Qizheng Xu (21077153)

    منشور في 2025
    "…Key mitochondrial genes, including SUCLG2, ACACB, OSBPL1A, and TRAP1, have been identified as significant prognostic markers in CRC. The expression of ACACB and OSBPL1A progressively increased, while SUCLG2 and TRAP1 expression decreased in patients. …"
  7. 887

    Supporting information Abou-Kandil et al. حسب Olaf Kniemeyer (8561361)

    منشور في 2024
    "…Deletion of <i>rtaA</i> did not significantly change the ergosterol content of <i>A. fumigatus</i>, but decreased fluorescence intensity of the sterol-binding stain filipin. …"
  8. 888

    MiR-15a-5p Knockdown up-Regulated ABCB1 Expression and Abated HNSCC Progression via the NF-κB Signaling Pathway حسب Jing Liu (38537)

    منشور في 2024
    "…The role of miR-15a-5p was investigated in the <i>in vivo</i> xenograft mouse model.</p> <p>ATP binding cassette transporter 1 (ABCB1) had the highest mutation frequency and multiple mutation types in HNSCC, and the decreased ABCB1 was significantly related to better prognosis of HNSCC patients. …"
  9. 889

    Fasting inhibits glycolysis and migration/invasion in gallbladder cancer via PCBP2/ANGPTL4 signaling حسب Ying Tao (469347)

    منشور في 2025
    "…Consistent evidence suggests that fasting has extensive antitumor effects in various cancers and influences levels of poly (rC)-binding protein 2 (PCBP2). However, whether fasting and PCBP2 are involved in GBC remains unknown. …"
  10. 890

    Data Sheet 1_Galangin ameliorates PTU-induced vitiligo in zebrafish and B16F10 cells by increasing melanogenesis through activation of the p38/JNK MAPK pathway.pdf حسب Zulipikaer Wusiman (20852138)

    منشور في 2025
    "…In addition, transcriptome analysis indicated that GA likely acts through the mitogen-activated protein kinase (MAPK) signaling pathway. GA has a strong binding affinity for important targets.GA significantly increased the expression of genes such as mapk8b, mapk14a, mapk3, mitf, tyr, tyrp1b, tyrp1a, dct, and oca2, and decreased the expression of genes such as expression of genes such as raf1 and egfr. …"
  11. 891

    Supplementary Material for: Identifying novel inflammatory protein biomarkers and drug targets of inflammatory bowel disease by integrating Mendelian randomization, bioinformatics,... حسب Wang F. (3215361)

    منشور في 2025
    "…Results: By integrating data from two cohorts, we demonstrated that genetically predicted CD40 (odds ratio [OR] = 0.878, 95% confidence interval [CI] = 0.838-0.919) and C-X-C motif chemokine ligand (CXCL)5 (OR = 0.884, 95%CI = 0.841-0.930) decreased IBD risk. However, genetically predicted CXCL9 (OR = 1.184, 95%CI = 1.084-1.294), Interleukin (IL)-18 (OR = 1.140, 95%CI = 1.076-1.208), CD6 (OR = 1.096, 95%CI = 1.045-1.150), and 4E-binding protein 1 (4E-BP1) (OR = 1.154, 95%CI = 1.070-1.244) increased IBD risk. …"
  12. 892

    Table_2_ATG5 and ATG7 Expression Levels Are Reduced in Cutaneous Melanoma and Regulated by NRF1.docx حسب Živa Frangež (5946392)

    منشور في 2025
    "…Results from immunohistochemistry show that the expression of ATG5 and ATG7 is significantly reduced in melanoma tissues compared to benign nevi. …"
  13. 893

    Image_2_ATG5 and ATG7 Expression Levels Are Reduced in Cutaneous Melanoma and Regulated by NRF1.jpg حسب Živa Frangež (5946392)

    منشور في 2025
    "…Results from immunohistochemistry show that the expression of ATG5 and ATG7 is significantly reduced in melanoma tissues compared to benign nevi. …"
  14. 894

    Table_1_ATG5 and ATG7 Expression Levels Are Reduced in Cutaneous Melanoma and Regulated by NRF1.docx حسب Živa Frangež (5946392)

    منشور في 2025
    "…Results from immunohistochemistry show that the expression of ATG5 and ATG7 is significantly reduced in melanoma tissues compared to benign nevi. …"
  15. 895

    Data Sheet 1_Pan-cancer analysis reveals TRA16 as a master regulator of human carcinogenesis.pdf حسب Yanyan Zhu (32035)

    منشور في 2025
    "…Introduction<p>The nuclear receptor TR4 binding protein, TRA16, has been implicated in lung carcinogenesis; however, its broader role across diverse human cancers remains poorly understood. …"
  16. 896

    Wheat germ agglutinin-nanoparticles encapsulating itacitinib target and suppress pro-inflammatory slan+ monocytes حسب Karen Alvarez (17620292)

    منشور في 2025
    "…</p> <p>We prepared ITA-loaded WGA/F127/PNPs and analyzed their binding and internalization in various leukocyte subsets using flow cytometry, focusing on slan+ and slan- monocytes. …"
  17. 897

    Image_1_ATG5 and ATG7 Expression Levels Are Reduced in Cutaneous Melanoma and Regulated by NRF1.jpg حسب Živa Frangež (5946392)

    منشور في 2025
    "…Results from immunohistochemistry show that the expression of ATG5 and ATG7 is significantly reduced in melanoma tissues compared to benign nevi. …"
  18. 898

    Loss of H2A.Z from transcription start sites was correlated with, but not required for, HU-induced gene activation. حسب Hilary T. Brewis (11798006)

    منشور في 2025
    "…The p-values, generated using hypergeometric probability, indicate if the overlap in each group was significantly greater (red) or less (blue) than excepted by chance (black = non-significant). …"
  19. 899

    Image 1_The role of E2F1 in promoting EIF4EBP1 transcription in cryptorchid mice: association with autophagy in germ cells.tif حسب Jianguo Zhang (6482)

    منشور في 2025
    "…E2F1 was identified as an upstream regulator of EIF4EBP1, with knockdown of E2F1 significantly decreasing EIF4EBP1 promoter activity and binding. …"
  20. 900

    Image 1_Polymorphous corneal dystrophy subtype 3 and keratoconus aggravation after corneal refractive surgery in a three-generation family carrying both ZEB1 and ZNF469 pathogenic... حسب Qinghong Lin (14162640)

    منشور في 2025
    "…One year later, visual acuity of III1 decreased significantly with KC aggravation and corneal opacification. …"