Table 2_Genomic profiling of NSCLC tumors with the TruSight oncology 500 assay provides broad coverage of clinically actionable genomic alterations and detection of known and novel... حسب Zachary D. Wallen (19986522)

"…Known associations between genomic alterations and immunotherapy markers were observed including significantly lower TMB levels in tumors with therapy-associated alterations and significantly higher PD-L1 levels in tumors with ALK, MET, BRAF, or ROS1 driver mutations. …"

Data Sheet 2_Systematic pharmacology-based strategy to investigate the mechanism of beta-sitosterol for the treatment of rheumarthritis.xlsx حسب Xiaodong Wang (66801)

"…The experimental results showed that β-sitosterol could significantly inhibit the excessive proliferation of MH7A cells (p< 0.05). …"

Data Sheet 1_Qinggan Yipi capsule ameliorates hepatic fibrosis in rats by down-regulating the TGF-β1/Smad2/3 signaling pathway and improving gut microbiota imbalance.docx حسب Wenjing Xue (2880686)

"…GO and KEGG analyses indicated that QgYp significantly affects TGF-β signaling pathway. In addition, the results of qPCR and Western blot analysis from both in vitro and in vivo experiments indicated that QgYp significantly downregulated the expression of proteins and mRNA associated with the TGF-β1/Smad2/3 pathway. …"

Image 2_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif حسب Toru Miwa (8528715)

"…Auditory brainstem response (ABR) thresholds were significantly elevated, and distortion-product otoacoustic emissions (DPOAE) indicated outer hair cell dysfunction. …"

Image 3_Hyodeoxycholic acid modulates gut microbiota and bile acid metabolism to enhance intestinal barrier function in piglets.tif حسب Jie Chong (18433611)

"…The results demonstrated that HDCA administration at 0.2 mg/mL suppressed body weight gain in piglets, which was alleviated by FMT. HDCA significantly altered gut microbiota composition in SPF piglets, markedly increasing the Lactobacillus abundance (37.97% vs. 5.28% in SPF-CON) while decreasing the proportion of Streptococcus (28.34% vs. 38.65%) and pathogenic family Erysipelotrichaceae (0.35% vs. 17.15%). …"

<i>DANCR</i> regulated genes in SK-MEL-28 cells. حسب Stephanie M. E. Jones (12883691)

"…MITF and c-MYC, key melanoma transcription factors, regulate human <i>DANCR</i> expression and melanoma patients with high <i>DANCR</i> display significantly decreased survival. <i>DANCR</i> is a melanoma oncogene that controls cancer-associated gene expression networks to promote human melanoma cell proliferation and migration. …"

Image 1_WGCNA-ML-MR integration: uncovering immune-related genes in prostate cancer.tif حسب Jing Lv (128179)

"…In q-PCR experiments conducted on tumor tissues and adjacent non-cancerous tissues from prostate cancer patients, it was found that: compared to the adjacent non-cancerous tissues, the expression level of ARHGEF38 in prostate cancer tumor tissues significantly increased, while the expression levels of SLC14A1, NEFH, MSMB, KRT23, and KRT15 significantly decreased. …"

Data Sheet 10_Congrong Shujing Granules ameliorates mitochondrial associated membranes to against MPP+-induced neurological damage in the cellular model of Parkinson’s disease.zip... حسب Chutian Zhang (10732350)

"…The serum effectively mitigated damage within the MAMs region and reduced both the mitochondrial-Ca²⁺ fluorescence intensity and the expression of the IP₃R-VDAC-MCU complex in MPP⁺-induced neuronal cells. Additionally, it significantly decreased the levels of ROS, the decline in MMP, and apoptosis rates in these cells.…"

Table 2_Causality of genetically determined serum metabolites on lower back pain or/and sciatica: a comprehensive Mendelian randomized study.docx حسب Yi-Ming Ren (555968)

"…Among them, 8 serum metabolites decreased risk of sciatica or/and lower back pain significantly (P < 0.05), and 14 serum metabolites increased risk of sciatica or/and lower back pain significantly (P < 0.05). …"

Data Sheet 13_Congrong Shujing Granules ameliorates mitochondrial associated membranes to against MPP+-induced neurological damage in the cellular model of Parkinson’s disease.zip... حسب Chutian Zhang (10732350)

"…The serum effectively mitigated damage within the MAMs region and reduced both the mitochondrial-Ca²⁺ fluorescence intensity and the expression of the IP₃R-VDAC-MCU complex in MPP⁺-induced neuronal cells. Additionally, it significantly decreased the levels of ROS, the decline in MMP, and apoptosis rates in these cells.…"

Data Sheet 1_Characterization of Ty21a immunostimulatory effects in the mouse bladder.pdf حسب Lenka Polak (17777406)

"…Indeed, CD8⁺ T-cell infiltration following Ty21a^FR was significantly decreased in TLR4- and MyD88-KO mice. In contrast, myeloid-cell recruitment was only reduced in MyD88-KO mice, suggesting the involvement of TLR4-independent pathways in that process. …"

Data Sheet 4_Congrong Shujing Granules ameliorates mitochondrial associated membranes to against MPP+-induced neurological damage in the cellular model of Parkinson’s disease.zip حسب Chutian Zhang (10732350)

"…The serum effectively mitigated damage within the MAMs region and reduced both the mitochondrial-Ca²⁺ fluorescence intensity and the expression of the IP₃R-VDAC-MCU complex in MPP⁺-induced neuronal cells. Additionally, it significantly decreased the levels of ROS, the decline in MMP, and apoptosis rates in these cells.…"

Data Sheet 7_Congrong Shujing Granules ameliorates mitochondrial associated membranes to against MPP+-induced neurological damage in the cellular model of Parkinson’s disease.zip حسب Chutian Zhang (10732350)

"…The serum effectively mitigated damage within the MAMs region and reduced both the mitochondrial-Ca²⁺ fluorescence intensity and the expression of the IP₃R-VDAC-MCU complex in MPP⁺-induced neuronal cells. Additionally, it significantly decreased the levels of ROS, the decline in MMP, and apoptosis rates in these cells.…"

Data Sheet 1_Preventive hyperbaric oxygen therapy improves acute graft-versus-host disease by activating the Nrf2/HO-1 pathway.pdf حسب Chao Xue (503328)

"…HBOT decreased ROS levels and proinflammatory cytokines, including IL-6 and TNF-α, while upregulated Nrf2 and its downstream antioxidant enzyme HO-1. …"

Data Sheet 3_Causality of genetically determined serum metabolites on lower back pain or/and sciatica: a comprehensive Mendelian randomized study.xlsx حسب Yi-Ming Ren (555968)

"…Among them, 8 serum metabolites decreased risk of sciatica or/and lower back pain significantly (P < 0.05), and 14 serum metabolites increased risk of sciatica or/and lower back pain significantly (P < 0.05). …"

Table1_Organic fertilizer increases pumpkin production by improving soil fertility.docx حسب Fangfang Ren (1835083)

"…Compared to CK, the average soil bulk density was significantly decreased by 8.27–18.51% (P< 0.05); the soil organic carbon, available phosphorus, available potassium, and nitrate nitrogen under H treatment were increased by an average of 32.37%, 21.85%, 18.70%, and 36.97%, respectively. …"

Image 3_The expanding role of 16s ribosomal RNA PCR in the management of patients with infective endocarditis undergoing cardiac surgery.tiff حسب Natalia Pavone (9442097)

"…The sensitivity of both valve culture and 16srRNA decreased significantly with prolonged preoperative antibiotic therapy. …"

Supplementary Material for: Assessment of the Factors Influencing Early Detection Practices of Oral Carcinomas by Dentists: A Cross-Sectional Study حسب figshare admin karger (2628495)

"…With increasing duration, the early detection practice scores decreased. Moreover, “guidelines about OC examinations” significantly predicted practice scores (higher scores where written guidelines were present) (P<0.001). …"

Image 1_The expanding role of 16s ribosomal RNA PCR in the management of patients with infective endocarditis undergoing cardiac surgery.tiff حسب Natalia Pavone (9442097)

"…The sensitivity of both valve culture and 16srRNA decreased significantly with prolonged preoperative antibiotic therapy. …"

Image 2_The expanding role of 16s ribosomal RNA PCR in the management of patients with infective endocarditis undergoing cardiac surgery.tiff حسب Natalia Pavone (9442097)

"…The sensitivity of both valve culture and 16srRNA decreased significantly with prolonged preoperative antibiotic therapy. …"