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challenge » challenges (Expand Search)
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1101
Data Sheet 1_Understanding mechanistic relationships between IgG titers and Fc effector functions: a computational framework to assess polyfunctionality.docx
Published 2025“…Surprisingly, simulated boosting of IgG3 alone had the potential to significantly decrease ADCP (p<0.00001), though it would increase ADCC responses. …”
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1102
Data Sheet 2_Characterization and immunoprotection of thioredoxin reductase TrxB knockout mutant of Salmonella Enteritidis.pdf
Published 2025“…We also observed a significant decrease in the expression of virulence-related genes in the trxB-knockout mutant. …”
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1103
Data Sheet 4_Characterization and immunoprotection of thioredoxin reductase TrxB knockout mutant of Salmonella Enteritidis.pdf
Published 2025“…We also observed a significant decrease in the expression of virulence-related genes in the trxB-knockout mutant. …”
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1104
Data Sheet 1_Perfusion process with tangential flow filtration for oncolytic VSV-GP production.docx
Published 2025“…The study showed that several input parameters and their interactions have significant impact on the infectious titer. Increasing the seeding cell density significantly improved the infectious titer, allowing infection at up to 46.6 × 10<sup>6</sup> cells mL<sup>-1</sup> without decrease in the cell-specific virus yield. …”
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1105
Data Sheet 3_Characterization and immunoprotection of thioredoxin reductase TrxB knockout mutant of Salmonella Enteritidis.pdf
Published 2025“…We also observed a significant decrease in the expression of virulence-related genes in the trxB-knockout mutant. …”
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1106
Data Sheet 5_Characterization and immunoprotection of thioredoxin reductase TrxB knockout mutant of Salmonella Enteritidis.pdf
Published 2025“…We also observed a significant decrease in the expression of virulence-related genes in the trxB-knockout mutant. …”
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1107
Data_Sheet_2_Antibacterial effects of human mesenchymal stem cells and their derivatives: a systematic review.PDF
Published 2024“…Introduction<p>The growing problem of antimicrobial resistance (AMR) poses a significant challenge to public health; This is partly due to the lack of advancements in the development of novel antibiotics and the pressing need for alternative treatment options. …”
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1108
Supplementary file 1_The interaction between obesity and sex alters the response to house dust mite in an experimental model of allergic lung inflammation.docx
Published 2025“…Similarly, HFD/HDM mice produce lower levels of IgE, IL-5, and IL-13 in the lungs after HDM challenge. However, HFD/Sham female mice displayed notable collagen accumulation in the airways, higher concentrations of SP-D in BAL, and a decrease in the relative gene expression of PECAM-1 in their lungs prior to HDM sensitisation.…”
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1109
Data_Sheet_1_Antibacterial effects of human mesenchymal stem cells and their derivatives: a systematic review.PDF
Published 2024“…Introduction<p>The growing problem of antimicrobial resistance (AMR) poses a significant challenge to public health; This is partly due to the lack of advancements in the development of novel antibiotics and the pressing need for alternative treatment options. …”
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1110
Protective effect of polyphenols from Potentilla anserina L. against in rat myocardial ischemia-reperfusion on injury by Wnt/β-catenin pathway
Published 2025“…Treatment of MIRI with PPA resulted in a significant decrease in protein expression levels of Wnt and β-catenin. …”
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1111
Data Sheet 1_Characterization and immunoprotection of thioredoxin reductase TrxB knockout mutant of Salmonella Enteritidis.pdf
Published 2025“…We also observed a significant decrease in the expression of virulence-related genes in the trxB-knockout mutant. …”
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1112
Data Sheet 1_Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets.csv
Published 2025“…Background<p>Type 2 Diabetes Mellitus (T2DM) represents a major global health challenge, marked by chronic hyperglycemia, insulin resistance, and immune system dysfunction. …”
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1113
Data Sheet 4_Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets.csv
Published 2025“…Background<p>Type 2 Diabetes Mellitus (T2DM) represents a major global health challenge, marked by chronic hyperglycemia, insulin resistance, and immune system dysfunction. …”
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1114
Data Sheet 2_Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets.csv
Published 2025“…Background<p>Type 2 Diabetes Mellitus (T2DM) represents a major global health challenge, marked by chronic hyperglycemia, insulin resistance, and immune system dysfunction. …”
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1115
Data Sheet 3_Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets.csv
Published 2025“…Background<p>Type 2 Diabetes Mellitus (T2DM) represents a major global health challenge, marked by chronic hyperglycemia, insulin resistance, and immune system dysfunction. …”
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1116
Table1_Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota.XLSX
Published 2024“…Improving survival rates and promoting recovery in patients with IS pose significant challenges, however, recent research has identified the gut–brain axis as a therapeutic target. …”
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1117
DataSheet2_Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota.zip
Published 2024“…Improving survival rates and promoting recovery in patients with IS pose significant challenges, however, recent research has identified the gut–brain axis as a therapeutic target. …”
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1118
DataSheet1_Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota.zip
Published 2024“…Improving survival rates and promoting recovery in patients with IS pose significant challenges, however, recent research has identified the gut–brain axis as a therapeutic target. …”
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1119
<b>Global pattern and drivers of disease heterogeneity in aging populations</b>
Published 2024“…<p dir="ltr">The unprecedented demographic shifts toward an aging population pose significant challenges to global healthcare systems. …”
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1120
Table2_Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota.XLSX
Published 2024“…Improving survival rates and promoting recovery in patients with IS pose significant challenges, however, recent research has identified the gut–brain axis as a therapeutic target. …”