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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
challenge » challenges (Expand Search)
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1341
Data Sheet 1_Use of HLA desensitization in the management of renal transplant recipients in Europe.pdf
Published 2025“…<p>A significant challenge in kidney transplantation is overcoming immunological barriers such as human leukocyte antigen (HLA) incompatibilities. …”
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1342
Table 1_Case Report: Application of accelerated continuous theta burst stimulation in treatment-resistant depression.docx
Published 2025“…<p>Treatment-resistant depression (TRD) poses a significant challenge in psychiatric practice. While repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising non-invasive neuromodulation technique for TRD, a subset of patients fails to respond adequately to these traditional rTMS protocols. …”
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1343
RE-AIM indicators.
Published 2025“…If successful, this model can significantly improve stillbirth prevention in low-resource settings.…”
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1344
Logic model based on ERIC-CFIR.
Published 2025“…If successful, this model can significantly improve stillbirth prevention in low-resource settings.…”
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1345
Data Sheet 1_Global, regional, and national epidemiology of otitis media in children from 1990 to 2021.docx
Published 2025“…</p>Conclusion<p>OM in children represents an escalating global health challenge, marked by a rising incidence. Although there has been a global decline in DALYs, the burden of DALYs associated with OM in children remains significant, particularly in regions with a low SDI. …”
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1346
Data Sheet 1_Associations between glycan signature alterations and the cellular antigenic properties of passaged chondrocytes.docx
Published 2024“…Background<p>Cartilage repair is a significant clinical challenge because of the limited intrinsic healing capacity. …”
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1347
Table 3_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.docx
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1348
Image 3_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.tif
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1349
Table 5_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.docx
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1350
Image 2_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.tif
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1351
DataSheet1_CircFOXO3 upregulation mediates the radioresistance of glioblastoma by affecting cellular metabolome.DOCX
Published 2024“…Introduction<p>Radioresistance remains a significant challenge in the treatment of glioblastoma multiforme (GBM), the most prevalent and lethal brain cancer in adults. …”
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1352
Table1_CircFOXO3 upregulation mediates the radioresistance of glioblastoma by affecting cellular metabolome.XLSX
Published 2024“…Introduction<p>Radioresistance remains a significant challenge in the treatment of glioblastoma multiforme (GBM), the most prevalent and lethal brain cancer in adults. …”
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1353
Table 1_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.docx
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1354
Table 4_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.docx
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1355
Table 2_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.docx
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1356
Data Sheet 1_Integrated computational and experimental identification of N-[(1H-1,2,4-triazol-3-yl)phenyl]-1-(1H-pyrazolo[3,4-b]pyridin-3-yl)methanamide as a potent and selective T...
Published 2025“…<p>Non-small cell lung cancer (NSCLC) remains a significant clinical challenge, necessitating exploration of novel therapeutic targets such as TIM-3. …”
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1357
Image 1_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.tif
Published 2025“…</p>Conclusions<p>CHD remains a significant global health challenge, with substantial disparities in disease burden across regions. …”
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1358
Data Sheet 1_Global burden of Type 2 Diabetes Mellitus attributable to dietary risks in elderly adults: insights from the Global Burden of Disease study 2021.docx
Published 2025“…Background<p>Type 2 Diabetes Mellitus (T2DM) poses a significant global health challenge, particularly among elderly adults. …”
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1359
Image 1_PipC affects the virulence of Salmonella enterica serovar Enteritidis and its deletion strain provides effective immune protection in mice.tif
Published 2025“…The results of the mouse intraperitoneal challenge experiment showed that compared with the wild-type strain, the 50% lethal dose (LD<sub>50</sub>) of the ΔpipC strain increased by 47 times, and the bacterial loads in the liver, spleen, and cecum were significantly reduced. …”
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1360
Data Sheet 1_Global, regional, and national burden and trends of intracerebral hemorrhage among adolescents and young adults aged 15–39 years from 1990 to 2021: a comprehensive tre...
Published 2025“…Background<p>Intracerebral hemorrhage (ICH) poses a significant health challenge, notably affecting adolescents and young adults (AYAs) aged 15–39 years. …”