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challenge » challenges (Expand Search)
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1381
Supplementary file 1_Efficacy of flavonoids in non-alcoholic fatty liver disease: an updated systematic review and meta-analysis.docx
Published 2025“…Flavonoids intervention significantly decreased aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT), total cholesterol (TC), steatosis score, body mass index (BMI), triglycerides (TG), fasting blood sugar (FBS), insulin levels and augmented the quantitative insulin sensitivity check index (QUICKI) levels. …”
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1382
Supplemental_Figure_of_Imeglimin_ameliorate_SA-AKI
Published 2025“…Serum ALT levels were not significantly different before and after E. coli challenge between the Ime and Veh groups. …”
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1383
Table 1_Improved medical protective clothing comfort for medical staff facing high-intensity infectious diseases.docx
Published 2025“…</p>Methods<p>To address this challenge, a novel integrated MPC was developed through the recombination of mainstream materials. …”
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1384
Supplementary Material for: Delayed Onset of Central Serous Chorioretinopathy (CSCR) following corticosteroid treatment for Giant Cell Arteritis (GCA): A Case Report
Published 2025“…The patient presented with decreased vision in the left eye for 10 days, prompting ophthalmologic evaluation. …”
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1385
Data Sheet 1_Global burden of inflammatory bowel disease in the elderly: trends from 1990 to 2021 and projections to 2051.docx
Published 2024“…</p>Conclusion<p>The absolute burden of IBD in the elderly population is projected to increase substantially by 2051, despite decreasing ASRs. These findings underscore the need for tailored healthcare strategies and resource allocation to address the growing challenge of elderly IBD globally.…”
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1386
Table 1_D-amino acid enhanced the sensitivity of avian pathogenic Escherichia coli to tetracycline and amikacin.doc
Published 2025“…<p>Avian pathogenic Escherichia coli (APEC) biofilm formation has led to increased antibiotic resistance, presenting a significant challenge for the prevention and control of the disease. …”
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1387
Table 2_D-amino acid enhanced the sensitivity of avian pathogenic Escherichia coli to tetracycline and amikacin.docx
Published 2025“…<p>Avian pathogenic Escherichia coli (APEC) biofilm formation has led to increased antibiotic resistance, presenting a significant challenge for the prevention and control of the disease. …”
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1388
Data Sheet 1_Global burden, trends and inequalities of maternal hypertensive disorders among reproductive-age women of advanced maternal age, 1990–2021: a population-based study.pd...
Published 2025“…Background<p>Maternal hypertensive disorders (MHD) are leading causes of maternal morbidity and mortality worldwide, particularly among reproductive-age women of advanced maternal age (AMA), representing a significant global public health challenge.</p>Objective<p>This study aimed to analyze the global trends, inequalities, and disparities in the burden of MHD among reproductive-age AMA women from 1990 to 2021.…”
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1389
Data Sheet 1_Mechanistic insights into pyrolysis temperature-dependent lead (Pb) stabilization in phytoremediation residue-derived biochar.docx
Published 2025“…<p>The substantial generation of hazardous, metal-enriched biomass residues poses significant risks of secondary contamination, presenting a critical bottleneck to the broader implementation of phytoremediation that urgently requires effective treatment solutions. …”
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1390
Data Sheet 1_Global, regional, and national burden of interstitial lung disease in middle-aged and older adults from 1990 to 2021 with projections to 2050: a systematic analysis of...
Published 2025“…Background<p>Interstitial lung disease (ILD) constitutes a significant global health challenge. However, existing epidemiological studies predominantly focus on worldwide and regional distribution patterns, while a substantial knowledge gap persists regarding the epidemiological characteristics of ILD among middle-aged and older adults (50–74 years). …”
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1391
Table 1_Spatio-temporal patterns and determinants of persistent catastrophic health expenditure in China: evidence from the China Family Panel Studies.docx
Published 2025“…Background<p>The escalating out-of-pocket medical expenses pose a significant threat to the financial stability of households worldwide. …”
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1392
Combating Chemoresistance in Breast Cancer: Exploring Tumor Microenvironment, Combination Therapies, and Drug Repurposing Strategies
Published 2025“…Chemoresistance in cancer can arise from a variety of molecular mechanisms, including active drug expulsion (drug efflux), decreased drug uptake, enhanced DNA repair mechanisms, the ability of cancer cells to evade programmed cell death (apoptosis), the diversity in the population of cancer cells within a tumor (tumor heterogeneity), and significant alterations in the tumor microenvironment (TME), where interactions between cancer cells, cancer-associated fibroblasts, immune cells, and the extracellular matrix contribute to a supportive environment that allows tumors to survive treatment and escape therapy. …”
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1393
Image 2_Computed tomography and magnetic resonance imaging features of primary liver perivascular epithelioid cell tumor with renal angiomyolipoma: a case report and literature rev...
Published 2025“…The enhancement slightly decreased in the equilibrium phase and the delayed phase. …”
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1394
Table 2_Adherence to recombinant human growth hormone therapy in children: influencing factors and clinical implications.xlsx
Published 2025“…However, non-adherence remains a significant challenge, affecting treatment efficacy and patient prognosis. …”
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1395
Table 1_Molecular and epigenetic responses to crowding stress in rainbow trout (Oncorhynchus mykiss) skeletal muscle.xlsx
Published 2025“…Background<p>Chronic stress is a critical challenge in fish aquaculture, adversely affecting growth, health, and overall productivity. …”
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1396
Image 1_Computed tomography and magnetic resonance imaging features of primary liver perivascular epithelioid cell tumor with renal angiomyolipoma: a case report and literature rev...
Published 2025“…The enhancement slightly decreased in the equilibrium phase and the delayed phase. …”
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1397
Table 1_Overcoming tet(X)-harboring tigecycline resistance: a study on the efficacy of tigecycline-apramycin combinations.docx
Published 2024“…Introduction<p>The emergence of the wide variety of novel tigecycline resistance tet(X) variants, including tet(X3), tet(X4), tet(X5), and tet(X6), has raised a serious threat to global public health and posed a significant challenge to the clinical treatment of multidrug-resistant bacterial infections.…”
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1398
Table 1_Adherence to recombinant human growth hormone therapy in children: influencing factors and clinical implications.xlsx
Published 2025“…However, non-adherence remains a significant challenge, affecting treatment efficacy and patient prognosis. …”
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1399
Table 1_Global, regional, and national burden of four major neurological diseases in women from 1990 to 2021.xlsx
Published 2025“…Contrary, the age-standardized DALY rate (ASDR) decreased in idiopathic epilepsy and multiple sclerosis. …”
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1400
Supplementary file 1_Global, regional, and national burden of four major neurological diseases in women from 1990 to 2021.docx
Published 2025“…Contrary, the age-standardized DALY rate (ASDR) decreased in idiopathic epilepsy and multiple sclerosis. …”