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challenge » challenges (Expand Search)
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1481
Data Sheet 1_Craving on the move: targeting smoking memories with a novel 3MDR–smoking cessation protocol.pdf
Published 2024“…Smoking cue–induced craving and physiological measures were assessed at baseline (T0) and 1 day after the intervention (T4), and smoking behavior was measured at T0 and 2-week (FU1) and 3-month (FU2) follow-up.</p>Results<p>Significant decreases in cue-induced craving from T0 to T4 and daily cigarette use from T0 to FU1 and FU2 were observed but not differ between the two experimental groups. …”
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1482
DataSheet1_Dysregulation of the 3β-hydroxysteroid dehydrogenase type 2 enzyme and steroid hormone biosynthesis in chronic kidney disease.pdf
Published 2024“…</p>Results<p>Metabolic characteristics revealed significant shifts in CKD, with 61 metabolites increased and 65 metabolites decreased, highlighting the disruption in steroid hormone biosynthesis pathways influenced by HSD3B2. …”
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1483
Table 3_Do the diagnosis-related group payment reforms have a negative impact?—an empirical study from Western China.docx
Published 2025“…In the treatment group hospitals, the primary beneficiaries of the reform were urban employees’ basic medical insurance patients, whose costs decreased by 4.9% (p < 0.01), with a non-significant effect on out-of-pocket payment patients and free medical care patients; the hospitals in the treatment group tended to reduce the use of Chinese medicine unique diagnostic and therapeutic means and increase the proportion of western medicine treatments under the pressure of the supremacy of costs.…”
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1484
Table 2_Do the diagnosis-related group payment reforms have a negative impact?—an empirical study from Western China.xlsx
Published 2025“…In the treatment group hospitals, the primary beneficiaries of the reform were urban employees’ basic medical insurance patients, whose costs decreased by 4.9% (p < 0.01), with a non-significant effect on out-of-pocket payment patients and free medical care patients; the hospitals in the treatment group tended to reduce the use of Chinese medicine unique diagnostic and therapeutic means and increase the proportion of western medicine treatments under the pressure of the supremacy of costs.…”
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1485
Image 2_Scalability of spheroid-derived small extracellular vesicles production in stirred systems.tif
Published 2025“…Implementing upstream processes in a chemically defined media in stirred-tank bioreactors (STBr) is mandatory to closely control the cell environment, and to scale-up production, but it remains a significant challenge for anchorage-dependent cells.…”
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1486
Study of monopolar plate springback applying zoned multistage forming process
Published 2025“…The length and width of an MPP both exceed 150 mm, but the thickness of its raw material plate is less than 0.1 mm, posing a significant challenge to the uniformity of its thickness after forming. …”
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1487
Image2_Integrating anoikis and ErbB signaling insights with machine learning and single-cell analysis for predicting prognosis and immune-targeted therapy outcomes in hepatocellula...
Published 2024“…Background<p>Hepatocellular carcinoma (HCC) poses a significant global health challenge due to its poor prognosis and limited therapeutic modalities. …”
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1488
Supplementary file 1_The association of dietary pattern with the risk of common chronic diseases in Shandong Province, China: a cross-sectional study.docx
Published 2025“…Background<p>Chronic diseases have emerged as a significant public health challenge, impacting the well-being of the Chinese populace, despite scant research exploring the influence of dietary factors on these conditions. …”
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1489
Image6_Integrating anoikis and ErbB signaling insights with machine learning and single-cell analysis for predicting prognosis and immune-targeted therapy outcomes in hepatocellula...
Published 2024“…Background<p>Hepatocellular carcinoma (HCC) poses a significant global health challenge due to its poor prognosis and limited therapeutic modalities. …”
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1490
Table 1_Effects of Veratrum nigrum expansion on soil microbial community structure in inner Mongolian mountain steppe.docx
Published 2025“…Compared with CK, the fungal Chao1 and Shannon diversity increased significantly in the S treatment, whereas the abundance of oligotrophs (Basidiomycota) decreased significantly. …”
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1491
Image1_Integrating anoikis and ErbB signaling insights with machine learning and single-cell analysis for predicting prognosis and immune-targeted therapy outcomes in hepatocellula...
Published 2024“…Background<p>Hepatocellular carcinoma (HCC) poses a significant global health challenge due to its poor prognosis and limited therapeutic modalities. …”
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1492
Image7_Integrating anoikis and ErbB signaling insights with machine learning and single-cell analysis for predicting prognosis and immune-targeted therapy outcomes in hepatocellula...
Published 2024“…Background<p>Hepatocellular carcinoma (HCC) poses a significant global health challenge due to its poor prognosis and limited therapeutic modalities. …”
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1493
Table1_Integrating anoikis and ErbB signaling insights with machine learning and single-cell analysis for predicting prognosis and immune-targeted therapy outcomes in hepatocellula...
Published 2024“…Background<p>Hepatocellular carcinoma (HCC) poses a significant global health challenge due to its poor prognosis and limited therapeutic modalities. …”
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1494
Image3_Integrating anoikis and ErbB signaling insights with machine learning and single-cell analysis for predicting prognosis and immune-targeted therapy outcomes in hepatocellula...
Published 2024“…Background<p>Hepatocellular carcinoma (HCC) poses a significant global health challenge due to its poor prognosis and limited therapeutic modalities. …”
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1495
Image5_Integrating anoikis and ErbB signaling insights with machine learning and single-cell analysis for predicting prognosis and immune-targeted therapy outcomes in hepatocellula...
Published 2024“…Background<p>Hepatocellular carcinoma (HCC) poses a significant global health challenge due to its poor prognosis and limited therapeutic modalities. …”
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1496
Image10_Integrating anoikis and ErbB signaling insights with machine learning and single-cell analysis for predicting prognosis and immune-targeted therapy outcomes in hepatocellul...
Published 2024“…Background<p>Hepatocellular carcinoma (HCC) poses a significant global health challenge due to its poor prognosis and limited therapeutic modalities. …”
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1497
Table 1_Do the diagnosis-related group payment reforms have a negative impact?—an empirical study from Western China.xlsx
Published 2025“…In the treatment group hospitals, the primary beneficiaries of the reform were urban employees’ basic medical insurance patients, whose costs decreased by 4.9% (p < 0.01), with a non-significant effect on out-of-pocket payment patients and free medical care patients; the hospitals in the treatment group tended to reduce the use of Chinese medicine unique diagnostic and therapeutic means and increase the proportion of western medicine treatments under the pressure of the supremacy of costs.…”
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1498
Data Sheet 1_Interstitial fluid transport in linea alba is involved in acupuncture-induced attenuation of ovarian hypofunction in aged rats.pdf
Published 2025“…Background<p>Age-related ovarian dysfunction, characterized by declining follicular reserve and hormonal imbalance, poses a significant challenge in reproductive endocrinology, severely compromising fertility and quality of life. …”
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1499
Supplementary file 1_MoodyTunes: a single cohort study of a music-based smartphone app for mental health and mood regulation in young people.pdf
Published 2025“…Depression was found to have decreased, although not at a statistically significant level. …”
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1500
Table 1_Improving postural stability through proprioceptive training in dogs.docx
Published 2025“…In contrast, large training effects (d > 0.8) for all significantly decreased parameters were found in the training group. …”