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challenge » challenges (Expand Search)
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1741
Image 2_Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden...
Published 2025“…Introduction<p>Congenital heart disease (CHD) represents a significant global public health burden, with substantial variability in mortality rates across different regions and age groups.…”
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1742
Spatial MTPX for the CCD.
Published 2025“…Spatially, the CCD demonstrates a characteristic pattern of decreasing from east to west. Overall, achieving a “cross-level transition” in CCD is challenging, and the neighboring provinces significantly influence the enhancement of local CCD. …”
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1743
Image 4_Phage (cocktail)-antibiotic synergism: a new frontier in addressing Klebsiella pneumoniae resistance.tif
Published 2025“…In vitro investigations demonstrated that the phage cocktail significantly decreased both planktonic and sessile cells. …”
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1744
DataSheet2_Diverse responses of hypoxia-inducible factor alpha mRNA abundance in fish exposed to low oxygen: the importance of reporting methods.CSV
Published 2024“…<p>Low dissolved oxygen (hypoxia) poses significant challenges to aquatic ecosystems, affecting the behavior, reproduction, and survival of aquatic organisms. …”
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1745
Effects of efgartigimod treatment on humoral and cellular immune responses: analysis of T-cell-dependent antibody response in cynomolgus monkeys
Published 2025“…No statistically significant differences emerged in anti-KLH IgM levels between the efgartigimod and control groups. …”
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1746
Data Sheet 1_Revealing fitness and virulence determinants of hypervirulent Klebsiella pneumoniae during infection in Galleria mellonella using a transposon library.pdf
Published 2025“…Going beyond the general knowledge that hypermucoviscosity (HMV) mediates high virulence, we observed that deficits in ptsI and GM2628 led to HMV while decreasing virulence. This exemplifies that HMV does not always directly correlate with virulence, challenging its role as a virulence marker and underscoring the need for further investigation into non-HMV-mediated virulence mechanisms.…”
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1747
Raw data of the subsystem.
Published 2025“…Spatially, the CCD demonstrates a characteristic pattern of decreasing from east to west. Overall, achieving a “cross-level transition” in CCD is challenging, and the neighboring provinces significantly influence the enhancement of local CCD. …”
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1748
Supplementary file 1_Burden of ageing spectrum of diseases in China, 1990–2021: a systematic analysis of global burden of disease study 2021.pdf
Published 2025“…Background<p>Population aging represents a pressing challenge for China, given its vast population and the growing proportion of adults aged 65 years and older. …”
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1749
Image 1_Sepsis in Internal Medicine: blood culture-based subtypes, hospital outcomes, and predictive biomarkers.tiff
Published 2025“…Background<p>Sepsis is a challenging condition increasingly managed in medical wards, however literature and clinical evidence in this hospital setting are lacking.…”
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1750
Supplementary Material for: Fetoscopic endoluminal tracheal occlusion in congenital diaphragmatic hernia: Unraveling the impact of prematurity and suboptimal fetal lung growth
Published 2025“…Introduction Congenital diaphragmatic hernia (CDH) poses significant challenges in both prenatal diagnosis and postnatal management. …”
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1751
Image 2_Sepsis in Internal Medicine: blood culture-based subtypes, hospital outcomes, and predictive biomarkers.tiff
Published 2025“…Background<p>Sepsis is a challenging condition increasingly managed in medical wards, however literature and clinical evidence in this hospital setting are lacking.…”
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1752
Data Sheet 1_Impacts of DRG point-based payment system on healthcare resource utilization and provider behavior: a pilot quasi-experimental study in China.docx
Published 2025“…</p>Results<p>After DRG-PBPS implementation, hospitalization costs decreased by 9.7% (p < 0.01), and length of stay decreased by 6.5% (p < 0.05). …”
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1753
Table 2_Genomic analysis, culturing optimization, and characterization of Escherichia bacteriophage OSYSP, previously studied as effective pathogen control on fresh produce.docx
Published 2024“…Incubation for 30 min at 4°C−47°C or pH 4–11 had no significant detrimental effect (p > 0.05) on phage infectivity. …”
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1754
Table 1_Genomic analysis, culturing optimization, and characterization of Escherichia bacteriophage OSYSP, previously studied as effective pathogen control on fresh produce.docx
Published 2024“…Incubation for 30 min at 4°C−47°C or pH 4–11 had no significant detrimental effect (p > 0.05) on phage infectivity. …”
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1755
Update on trimethylamine N-oxide (TMAO) as a piezolyte and cryoprotectant: its role in a depth limit for marine fishes and loss from hadal fish during capture
Published 2025“…<p dir="ltr"><b>I</b><b>NTRODUCTION</b></p><p dir="ltr">Trimethylamine N-oxide (TMAO) is a small organic molecule found at osmotically-significant concentrations in many marine animal taxa. …”
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1756
Supplementary file 1_Cell wall modulation by drought and elevated CO2 in sugarcane leaves.docx
Published 2025“…<p>Climate change poses significant challenges to global agriculture, with elevated atmospheric CO2 (eCO<sub>2</sub>) concentrations and increased frequency of droughts affecting crop productivity. …”
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1757
Data Sheet 3_Cell wall modulation by drought and elevated CO2 in sugarcane leaves.xlsx
Published 2025“…<p>Climate change poses significant challenges to global agriculture, with elevated atmospheric CO2 (eCO<sub>2</sub>) concentrations and increased frequency of droughts affecting crop productivity. …”
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1758
Data Sheet 4_Cell wall modulation by drought and elevated CO2 in sugarcane leaves.xlsx
Published 2025“…<p>Climate change poses significant challenges to global agriculture, with elevated atmospheric CO2 (eCO<sub>2</sub>) concentrations and increased frequency of droughts affecting crop productivity. …”
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1759
Data Sheet 1_Cell wall modulation by drought and elevated CO2 in sugarcane leaves.xlsx
Published 2025“…<p>Climate change poses significant challenges to global agriculture, with elevated atmospheric CO2 (eCO<sub>2</sub>) concentrations and increased frequency of droughts affecting crop productivity. …”
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1760
Data Sheet 2_Cell wall modulation by drought and elevated CO2 in sugarcane leaves.xlsx
Published 2025“…<p>Climate change poses significant challenges to global agriculture, with elevated atmospheric CO2 (eCO<sub>2</sub>) concentrations and increased frequency of droughts affecting crop productivity. …”