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significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
challenges decrease » challenges case (Expand Search)
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18721
Table 1_Growth regulation mechanism of Rhododendron moulmainense to high-temperature stress: integrated physiological, transcriptomic, and metabolomic insights.xlsx
Published 2025“…The findings demonstrated that high-temperature stress decreased chlorophyll fluorescence and contents, which was validated by the damaged chloroplast structure in transmission electron microscopy. …”
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18722
Table 5_Profiling of small RNAs derived from tomato brown rugose fruit virus in infected Solanum lycopersicum plants by deep sequencing.xlsx
Published 2025“…Seven potential target genes were selected for qRT-PCR analysis, confirming that their transcript accumulation significantly decreased in the leaves of tomato plants infected with ToBRFV. …”
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18723
Table 6_Profiling of small RNAs derived from tomato brown rugose fruit virus in infected Solanum lycopersicum plants by deep sequencing.xlsx
Published 2025“…Seven potential target genes were selected for qRT-PCR analysis, confirming that their transcript accumulation significantly decreased in the leaves of tomato plants infected with ToBRFV. …”
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18724
Supplementary Figures for AJP-Integr Reg Comp Physiol R-00035-2025R1
Published 2025“…<i>In vivo</i>, carcass, heart, and fat mass were significantly reduced in the tumor-bearing mice. Skeletal muscle growth was impeded in the GL261 hosts, along with smaller muscle CSA. …”
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18725
Image 2_Transcriptome-based WGCNA reveals the molecular regulation of xylem plasticity in acclimation to drought and rewatering in mulberry.tif
Published 2024“…Most parameters were not affected significantly under moderate drought for both cultivars. …”
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18726
Table 1_Effects of selenium-mediated RUNX2 overexpression and its transcriptome alterations on Chondrocyte injury in Kashin Beck disease.docx
Published 2025“…Inhibition of DNA methylation confirmed that decreased methylation of RUNX2 promoted its transcription. …”
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18727
<b>Association between myristic acid in plasma triglycerides and metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes: A comprehensive analysis...
Published 2025“…After comprehensive diabetes treatment for 2 weeks, FA levels in many TGs significantly decreased; especially, FA 14:0 levels in TGs decreased notably, and this reduction was more pronounced in patients with MASLD.…”
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18728
Table 1_Early identification of sarcopenia in patients with diabetes mellitus combined with osteoporosis: development and validation of a gender-specific nomogram.docx
Published 2025“…</p>Results<p>The prevalence of sarcopenia in patients with T2DM combined with osteoporosis was 33.88%, with men having a significantly higher prevalence than women. Among male patients, body mass index, 25-hydroxyvitamin D, and calcium levels were associated with a decreased risk of sarcopenia, whereas age and weight-adjusted waist index were associated with an increased risk. …”
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18729
Table 3_Profiling of small RNAs derived from tomato brown rugose fruit virus in infected Solanum lycopersicum plants by deep sequencing.xls
Published 2025“…Seven potential target genes were selected for qRT-PCR analysis, confirming that their transcript accumulation significantly decreased in the leaves of tomato plants infected with ToBRFV. …”
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18730
Data Sheet 1_HAX1, gene responsible for Kostmann syndrome, regulates gingival epithelial barrier function via intracellular trafficking of JAM1.pdf
Published 2025“…In HAX1-knockdown IHGE cells, significantly decreased levels of JAM1 were found. Additionally, cisplatin, a chemotherapeutic agent reported to inhibit HAX1, also led to decreased expression of both HAX1 and JAM1. …”
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18731
Table2_Maslinic acid induces autophagy and ferroptosis via transcriptomic and metabolomic reprogramming in prostate cancer cells.xlsx
Published 2024“…Herein we found that MA inhibits prostate cancer cell proliferation by decreasing CDK2, CDK4, and CDK6 expression and concurrently increasing p27, Rb, p-Rb expression. …”
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18732
Table 2_Mechanism of Huaiqihuang (HQH) against cyclophosphamide (CYP)-induced hippocampal neurotoxicity based on network pharmacology, molecular docking and experimental verificati...
Published 2025“…Experimental validation using Western blot confirmed that HQH significantly decreased the protein expression of TNF, HSP90AA1, TP53, and MAPK1 in hippocampal tissues.…”
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18733
Table 1_Characteristics of the vaginal microbiota and vaginal metabolites in women with cervical dysplasia.docx
Published 2024“…Correlation analysis revealed positive associations between CC group-decreased Lactobacillus abundance and CC group-decreased metabolites. …”
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18734
Deletion of glycosyltransferase <i>galE</i> impairs the InlB anchoring and pathogenicity of <i>Listeria monocytogenes</i>
Published 2024“…Taken together, <i>galE</i> deletion significantly reduced the anchoring of InlB and weakened the pathogenicity of <i>L. monocytogenes</i>. …”
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18735
Data Sheet 2_Comprehensive analysis of SQOR involvement in ferroptosis resistance of pancreatic ductal adenocarcinoma in hypoxic environments.docx
Published 2025“…SQOR knockdown resulted in decreased cell viability, decreased migration ability and increased MDA level under hypoxic Ersatin induced conditions. …”
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18736
Image 1_Profiling of small RNAs derived from tomato brown rugose fruit virus in infected Solanum lycopersicum plants by deep sequencing.jpeg
Published 2025“…Seven potential target genes were selected for qRT-PCR analysis, confirming that their transcript accumulation significantly decreased in the leaves of tomato plants infected with ToBRFV. …”
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18737
Data Sheet 1_Menthone lowers H3K27ac levels to inhibit Fusarium proliferatum growth.docx
Published 2025“…</p>Results<p>This study demonstrated that menthone, the primary component of Mentha haplocalyx EO, exhibited notable antifungal activity against Fusarium proliferatum (EC50 = 6.099 mmol/L). The treatment significantly inhibited hyphal growth, reduced spore germination rates from 31.49 to 4.95%, decreased spore viability from 46.88 to 20.91%, and reduced spore production by a factor of 17.92 compared with the control group while simultaneously enhancing cell membrane permeability. …”
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18738
Table 2_Profiling of small RNAs derived from tomato brown rugose fruit virus in infected Solanum lycopersicum plants by deep sequencing.xls
Published 2025“…Seven potential target genes were selected for qRT-PCR analysis, confirming that their transcript accumulation significantly decreased in the leaves of tomato plants infected with ToBRFV. …”
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18739
Table 4_Mechanism of Huaiqihuang (HQH) against cyclophosphamide (CYP)-induced hippocampal neurotoxicity based on network pharmacology, molecular docking and experimental verificati...
Published 2025“…Experimental validation using Western blot confirmed that HQH significantly decreased the protein expression of TNF, HSP90AA1, TP53, and MAPK1 in hippocampal tissues.…”
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18740
Supplementary Material for: Efficacy of Spray Cryotherapy on Airway Secretions in Canine Models of Chronic Bronchitis and Mechanism Insights
Published 2025“…SCT treatment reduced mucus and pulmonary resistance, improved bronchial structure, and decreased goblet cells. SCT significantly reduced BALF mucin, MUC5AC, MUC5B, acetylcholine, IL-6, INF-γ, TNF-α, and IL-10, and bronchial MUC5AC and CHRM3. …”