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significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
challenges decrease » challenges case (Expand Search)
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19461
Data Sheet 1_Effect of NR1D1 on the proliferation and differentiation of yak skeletal muscle satellite cells.pdf
Published 2024“…Compared with those in the control group, the expression levels of proliferation marker genes KI-67, CYCLIND1, and CYCLINA were significantly inhibited after NR1D1 overexpression, which was also supported by the CCK-8 test, whereas differentiation marker genes MYOD, MYOG, and MYF5 were significantly inhibited. …”
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19462
Table3_Transcriptomic profiling with vascular tension analyses reveals molecular targets and phenotypes in preeclamptic placental vasculature.xlsx
Published 2024“…Several hub genes, including ELMO1, YWHAE, and IL6ST, were significantly reduced in the placental vessels in preeclampsia. …”
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19463
Table 2_Plasma exosomal miRNA expression and gut microbiota dysbiosis are associated with cognitive impairment in Alzheimer’s disease.docx
Published 2025“…</p>Results<p>Four exosomal miRNAs and 14 microbiota taxa, which exhibited differential expression and abundance, respectively, in comparison between AD group and normal cognition group, were identified to be significantly associated with MMSE scores. Notably, the abundance of potential probiotics, including Faecalibacterium prausnitzii, Roseburia intestinalis and Roseburia inulinivorans, which was decreased in AD patients, exhibited positive correlations with specific exosomal miRNAs: Roseburia intestinalis correlated with miR-3120-3p and miR-6529-5p; Roseburia inulinivorans correlated with miR-3120-3p, miR-6529-5p and miR-124-3p; Faecalibacterium prausnitzii correlated with miR-3120-3p.…”
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19464
Supplementary Material for: MicroRNA-4497 is Downregulated in Pediatric Allergic Diseases and Suppresses Th2 Inflammation in an Animal Model
Published 2025“…Furthermore, levels of IL-4, MDC and methacholine Penh were significantly decreased in a miR-4497 treated mouse model. …”
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19465
Global maximum GPP from 2001-2018
Published 2025“…The GPPmax estimates from this study and the changes in their trends were highly correlated with GPPmax estimates from the vegetation photosynthesis model, with R2 > 0.70 for most vegetation types. The GPPmax significantly increased in western North America, northern Europe, and eastern China, but decreased in tropical regions. …”
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19466
Data Sheet 1_Desulfovibrio vulgaris exacerbates sepsis by inducing inflammation and oxidative stress in multiple organs.pdf
Published 2025“…Phosphorylation of MAPK and NF-κB pathways in peritoneal macrophages was significantly enhanced. Additionally, D. vulgaris amplified oxidative stress across multiple organs, as indicated by increased ROS levels and decreased antioxidant enzyme activity.…”
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19467
Table 1_Downregulation of HDGF inhibits tumorigenic phenotypes of hypopharyngeal squamous cell carcinoma by suppressing the AKT/mTOR/VEGF pathway.xlsx
Published 2025“…In FaDu HSCC cells, siRNA-mediated HDGF knockdown significantly attenuated proliferation, migration, and invasion. …”
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19468
Table 2_Outcomes after liposuction-based treatment of lymphedema: a systematic review and meta-analysis.docx
Published 2025“…Combined approaches achieved slightly lower reductions (87.31%), but significantly decreased compression dependence, improved lymphatic function, and enhanced QOL. …”
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19469
Table 1_Regional and age-specific global trends associated with infectious diarrhea in children under 14 years old caused by pathogenic microorganisms in 2021.docx
Published 2025“…</p>Conclusion<p>Although the global burden of diarrhea has decreased significantly, it is still high in low-income countries and low- and medium-SDI areas, and newborns are at high risk. …”
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19470
Supplementary Material for: Comparing Two Oral Immunotherapy Strategies for Sesame Allergy: Baked Goods with Sesame Paste Versus Crushed Sesame Seeds
Published 2025“…For both the baked goods and the seeds group, likelihood of severe reactions significantly decreased over time. Conclusion: A modified sesame desensitization protocol using baked sesame paste can be safely used in children with sesame allergy.…”
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19471
Table 6_Global, regional and national burden of traumatic amputations from 1990 to 2021: a systematic analysis of the Global Burden of Disease study 2021.docx
Published 2025“…However, the change in age-standardized rates from 1990 to 2021 declined significantly. The association between the Socio-demographic Index (SDI) and the burden of amputations in 2021 was not linear. …”
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19472
Data Sheet 1_The pan-cancer landscape of aldo-keto reductase1B10 reveals that its expression is diminished in gastric cancer.docx
Published 2024“…In tumor microenvironment, AKR1B10 was significantly correlated with immune cell infiltrations and immune gene expression. …”
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19473
Image 1_Construction of a novel cuproptosis-related gene signature for predicting microenvironment, prognosis and therapeutic response in cervical cancer.tif
Published 2025“…Moreover, the overexpression of FOXJ1 (one of the DEGs) significantly decreased the proliferation, invasion, migration and Epithelial-Mesenchymal Transition (EMT) process in cervical cancer cells. …”
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19474
Image 3_A putative glucose-1-phosphate thymidylyltransferase is required for virulence, membrane-associated mechanisms, and tolerance to external stresses in Acidovorax citrulli.ti...
Published 2025“…Notably, the mutant was highly susceptible to multiple stress conditions—including ethylenediaminetetraacetic acid, acetic acid, cupric chloride, sodium dodecyl sulfate, and pH stress—as indicated by significantly decreased OD values or colony forming units (CFUs) compared to the wild type. …”
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19475
Presentation_1_Notoginsenoside R1 Protects Against Diabetic Cardiomyopathy Through Activating Estrogen Receptor α and Its Downstream Signaling.pdf
Published 2025“…In vitro experiments revealed that pretreatment with NGR1 significantly decreased AGEs-induced mitochondria injury, limited an increase in ROS, and reduced apoptosis in H9c2 cells. …”
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19476
Image 3_HIF‐1α modulates pancreatic cancer ECM proteins via the TGF‐β1/Smad signaling pathway introduction.tif
Published 2025“…Pharmacological inhibition of either HIF-1α or TGF-β1 significantly decreased the expression of ECM proteins, while TGF-β1 stimulation enhanced their production. …”
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19477
Defective autophagy in vascular smooth muscle cells promote uremic accelerated atherosclerosis
Published 2025“…<p>Individuals with chronic kidney disease (CKD) exhibit a significantly elevated risk of premature mortality, predominantly attributable to cardiovascular etiologies. …”
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19478
Data Sheet 1_Herbal essential oils improve growth, antioxidant response, and gene expression in Nile Tilapia fingerlings.pdf
Published 2025“…</p>Results and discussion<p>The 30 and 60 mL/kg groups showed significantly improved final body weight, weight gain, specific growth rate, and feed conversion ratio (p < 0.05). …”
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19479
Table 4_Gut microbiota alterations in golden snub-nosed monkeys during food shortage and parturition-nursing periods.doc
Published 2025“…We found that in adult males, gut microbiota diversity significantly decreased in food shortages and parturition-nursing period. …”
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19480
Natural selection diagram.
Published 2025“…Additionally, the variation in node utilization rates significantly decreased from 30.1% to 12.25%, markedly enhancing resource scheduling efficiency and overall balance within the supply chain.…”