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significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
challenges decrease » challenges case (Expand Search)
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1041
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1042
Table 1_Are alternatively organized value chains more environmentally sustainable? Evidence from soybean production in Minas Gerais and Paraná states, Brazil.docx
Published 2025“…<p>The predominant agro-industrial soybean production in Brazil has led to a significant socio-ecological crisis. Alternative agriculture has been increasingly marketed as a viable solution to the multifaceted challenges engendered by this intensive production system in the Atlantic Forest biome of Brazil and its related global value chains. …”
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1043
Table 1_Burden of esophageal cancer in global, regional and national regions from 1990 to 2021 and its projection until 2050: results from the GBD study 2021.docx
Published 2025“…</p>Conclusions<p>The global burden of EC remains significant, with ongoing challenges in regions such as Africa and East Asia. …”
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1044
Computed tomography-guided radiofrequency ablation of nasal carcinomas in dogs.
Published 2024“…<p dir="ltr">Nasal carcinomas in dogs are locally invasive neoplasms with a low metastatic rate that pose significant treatment challenges due to their location and aggressiveness. …”
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1045
DataSheet1_Detecting centennial changes in the clarity and colour of the Red and Eastern Mediterranean Seas by retracing the “Pola” expeditions.pdf
Published 2025“…The results show a significant greening of both regions investigated as well as a decrease in water clarity. …”
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1046
DataSheet2_Detecting centennial changes in the clarity and colour of the Red and Eastern Mediterranean Seas by retracing the “Pola” expeditions.csv
Published 2025“…The results show a significant greening of both regions investigated as well as a decrease in water clarity. …”
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1047
Data Sheet 1_Trends in nontraumatic subarachnoid hemorrhage-related mortality among young adult (15–64 years) population in the United States, 1999–2022.docx
Published 2025“…Background<p>Nontraumatic subarachnoid hemorrhages (NSAH) are the result of intracranial aneurysm rupture and involve bleeding into subarachnoid space. NSAH causes significant stroke burden among adults in the United States (US). …”
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1048
DTG 3TC HIV EPI study.xlsx
Published 2024“…<p dir="ltr">The persistence of human immunodeficiency virus (HIV) within viral reservoirs poses significant challenges to eradication efforts. Epigenetic alterations, including DNA methylation, are potential factors influencing HIV latency and persistence. …”
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1049
Image 1_Application of adaptive virtual synchronous generator based on improved active power loop in photovoltaic storage systems.pdf
Published 2025“…<p>In the process of integrating distributed energy, photovoltaic (PV) power generation systems encounter issues of intermittency and volatility, posing significant challenges to the stability of the power grid. …”
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1050
Table 1_Nutritionally adequate, healthy, and climate-friendly diets following the Nordic Nutrition Recommendations 2023: an optimization study for Norway.xlsx
Published 2025“…Regardless of degree of environmental impact reduction, diets following NNR2023 guidelines will require significant dietary changes compared to observed intake, including an increase in consumption of fruits, vegetables, and grains, and a strong decrease in consumption of red meat, total meat, and discretionary foods. …”
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1051
Data Sheet 1_Prevalence trend and burden of foodborne trematodiasis in China from 1990 to 2021 and its predictions until 2030: a comparative study with Japan and South Korea.csv
Published 2025“…Background<p>Foodborne trematodiasis (FBT) poses a significant public health challenge in East Asia, influenced by local dietary practices and environmental conditions. …”
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1052
Presentation 1_Prevalence trend and burden of foodborne trematodiasis in China from 1990 to 2021 and its predictions until 2030: a comparative study with Japan and South Korea.pdf
Published 2025“…Background<p>Foodborne trematodiasis (FBT) poses a significant public health challenge in East Asia, influenced by local dietary practices and environmental conditions. …”
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1053
Data Sheet 2_Prevalence trend and burden of foodborne trematodiasis in China from 1990 to 2021 and its predictions until 2030: a comparative study with Japan and South Korea.docx
Published 2025“…Background<p>Foodborne trematodiasis (FBT) poses a significant public health challenge in East Asia, influenced by local dietary practices and environmental conditions. …”
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1054
Data Sheet 1_Safety and immunomodulatory efficacy of heat-killed Mycolicibacterium manresensis as a novel paraprobiotic in swine.pdf
Published 2025“…Piglets supplemented with higher doses of hkMm exhibited a significant increase in salivary adenosine deaminase levels (p = 0.0042), along with a significant decrease in serum haptoglobin concentration (p = 0.0263). …”
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1055
Table 1_Experiences of reintegration, relapse, and readmission: a qualitative study among patients with alcohol use disorder in Uganda.docx
Published 2025“…Introduction<p>Alcohol Use Disorder (AUD) is a significant public health concern in Uganda, with many patients experiencing relapses. …”
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1056
Table1_Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota.XLSX
Published 2024“…Improving survival rates and promoting recovery in patients with IS pose significant challenges, however, recent research has identified the gut–brain axis as a therapeutic target. …”
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1057
DataSheet2_Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota.zip
Published 2024“…Improving survival rates and promoting recovery in patients with IS pose significant challenges, however, recent research has identified the gut–brain axis as a therapeutic target. …”
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1058
DataSheet1_Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota.zip
Published 2024“…Improving survival rates and promoting recovery in patients with IS pose significant challenges, however, recent research has identified the gut–brain axis as a therapeutic target. …”
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1059
<b>Global pattern and drivers of disease heterogeneity in aging populations</b>
Published 2024“…<p dir="ltr">The unprecedented demographic shifts toward an aging population pose significant challenges to global healthcare systems. …”
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1060
Table2_Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota.XLSX
Published 2024“…Improving survival rates and promoting recovery in patients with IS pose significant challenges, however, recent research has identified the gut–brain axis as a therapeutic target. …”